| Literature DB >> 25607358 |
Derrek P Hibar1, Jason L Stein2, Miguel E Renteria3, Alejandro Arias-Vasquez4, Sylvane Desrivières5, Neda Jahanshad1, Roberto Toro6, Katharina Wittfeld7, Lucija Abramovic8, Micael Andersson9, Benjamin S Aribisala10, Nicola J Armstrong11, Manon Bernard12, Marc M Bohlken8, Marco P Boks8, Janita Bralten13, Andrew A Brown14, M Mallar Chakravarty15, Qiang Chen16, Christopher R K Ching17, Gabriel Cuellar-Partida3, Anouk den Braber18, Sudheer Giddaluru19, Aaron L Goldman16, Oliver Grimm20, Tulio Guadalupe21, Johanna Hass22, Girma Woldehawariat23, Avram J Holmes24, Martine Hoogman25, Deborah Janowitz26, Tianye Jia5, Sungeun Kim27, Marieke Klein25, Bernd Kraemer28, Phil H Lee29, Loes M Olde Loohuis30, Michelle Luciano31, Christine Macare5, Karen A Mather32, Manuel Mattheisen33, Yuri Milaneschi34, Kwangsik Nho27, Martina Papmeyer35, Adaikalavan Ramasamy36, Shannon L Risacher37, Roberto Roiz-Santiañez38, Emma J Rose39, Alireza Salami40, Philipp G Sämann41, Lianne Schmaal34, Andrew J Schork42, Jean Shin12, Lachlan T Strike43, Alexander Teumer44, Marjolein M J van Donkelaar25, Kristel R van Eijk8, Raymond K Walters45, Lars T Westlye46, Christopher D Whelan1, Anderson M Winkler47, Marcel P Zwiers48, Saud Alhusaini49, Lavinia Athanasiu14, Stefan Ehrlich50, Marina M H Hakobjan25, Cecilie B Hartberg51, Unn K Haukvik52, Angelien J G A M Heister25, David Hoehn41, Dalia Kasperaviciute53, David C M Liewald31, Lorna M Lopez31, Remco R R Makkinje25, Mar Matarin54, Marlies A M Naber25, D Reese McKay55, Margaret Needham56, Allison C Nugent23, Benno Pütz41, Natalie A Royle57, Li Shen27, Emma Sprooten58, Daniah Trabzuni59, Saskia S L van der Marel25, Kimm J E van Hulzen25, Esther Walton22, Christiane Wolf41, Laura Almasy60, David Ames61, Sampath Arepalli62, Amelia A Assareh32, Mark E Bastin63, Henry Brodaty32, Kazima B Bulayeva64, Melanie A Carless65, Sven Cichon66, Aiden Corvin56, Joanne E Curran65, Michael Czisch41, Greig I de Zubicaray67, Allissa Dillman62, Ravi Duggirala65, Thomas D Dyer60, Susanne Erk68, Iryna O Fedko18, Luigi Ferrucci69, Tatiana M Foroud70, Peter T Fox71, Masaki Fukunaga72, J Raphael Gibbs73, Harald H H Göring65, Robert C Green74, Sebastian Guelfi75, Narelle K Hansell3, Catharina A Hartman76, Katrin Hegenscheid77, Andreas Heinz78, Dena G Hernandez73, Dirk J Heslenfeld79, Pieter J Hoekstra76, Florian Holsboer41, Georg Homuth80, Jouke-Jan Hottenga18, Masashi Ikeda81, Clifford R Jack82, Mark Jenkinson83, Robert Johnson84, Ryota Kanai85, Maria Keil28, Jack W Kent65, Peter Kochunov86, John B Kwok87, Stephen M Lawrie35, Xinmin Liu88, Dan L Longo89, Katie L McMahon90, Eva Meisenzahl91, Ingrid Melle14, Sebastian Mohnke68, Grant W Montgomery3, Jeanette C Mostert25, Thomas W Mühleisen92, Michael A Nalls62, Thomas E Nichols93, Lars G Nilsson9, Markus M Nöthen94, Kazutaka Ohi95, Rene L Olvera96, Rocio Perez-Iglesias97, G Bruce Pike98, Steven G Potkin99, Ivar Reinvang100, Simone Reppermund32, Marcella Rietschel20, Nina Romanczuk-Seiferth68, Glenn D Rosen101, Dan Rujescu91, Knut Schnell102, Peter R Schofield87, Colin Smith103, Vidar M Steen19, Jessika E Sussmann35, Anbupalam Thalamuthu32, Arthur W Toga104, Bryan J Traynor62, Juan Troncoso105, Jessica A Turner106, Maria C Valdés Hernández107, Dennis van 't Ent18, Marcel van der Brug108, Nic J A van der Wee109, Marie-Jose van Tol110, Dick J Veltman34, Thomas H Wassink111, Eric Westman112, Ronald H Zielke84, Alan B Zonderman113, David G Ashbrook114, Reinmar Hager114, Lu Lu115, Francis J McMahon23, Derek W Morris116, Robert W Williams117, Han G Brunner118, Randy L Buckner119, Jan K Buitelaar120, Wiepke Cahn8, Vince D Calhoun121, Gianpiero L Cavalleri1, Benedicto Crespo-Facorro38, Anders M Dale122, Gareth E Davies123, Norman Delanty124, Chantal Depondt125, Srdjan Djurovic126, Wayne C Drevets127, Thomas Espeseth46, Randy L Gollub128, Beng-Choon Ho129, Wolfgang Hoffmann130, Norbert Hosten77, René S Kahn8, Stephanie Le Hellard19, Andreas Meyer-Lindenberg20, Bertram Müller-Myhsok131, Matthias Nauck132, Lars Nyberg9, Massimo Pandolfo125, Brenda W J H Penninx34, Joshua L Roffman133, Sanjay M Sisodiya134, Jordan W Smoller135, Hans van Bokhoven25, Neeltje E M van Haren8, Henry Völzke44, Henrik Walter68, Michael W Weiner136, Wei Wen32, Tonya White137, Ingrid Agartz138, Ole A Andreassen14, John Blangero60, Dorret I Boomsma18, Rachel M Brouwer8, Dara M Cannon139, Mark R Cookson62, Eco J C de Geus18, Ian J Deary31, Gary Donohoe116, Guillén Fernández140, Simon E Fisher141, Clyde Francks141, David C Glahn55, Hans J Grabe142, Oliver Gruber143, John Hardy75, Ryota Hashimoto144, Hilleke E Hulshoff Pol8, Erik G Jönsson145, Iwona Kloszewska146, Simon Lovestone147, Venkata S Mattay148, Patrizia Mecocci149, Colm McDonald150, Andrew M McIntosh151, Roel A Ophoff152, Tomas Paus153, Zdenka Pausova154, Mina Ryten155, Perminder S Sachdev156, Andrew J Saykin157, Andy Simmons158, Andrew Singleton62, Hilkka Soininen159, Joanna M Wardlaw63, Michael E Weale160, Daniel R Weinberger161, Hieab H H Adams162, Lenore J Launer163, Stephan Seiler164, Reinhold Schmidt164, Ganesh Chauhan165, Claudia L Satizabal166, James T Becker167, Lisa Yanek168, Sven J van der Lee169, Maritza Ebling170, Bruce Fischl171, W T Longstreth172, Douglas Greve170, Helena Schmidt173, Paul Nyquist174, Louis N Vinke170, Cornelia M van Duijn169, Luting Xue175, Bernard Mazoyer176, Joshua C Bis177, Vilmundur Gudnason178, Sudha Seshadri179, M Arfan Ikram162, Nicholas G Martin3, Margaret J Wright180, Gunter Schumann5, Barbara Franke181, Paul M Thompson1, Sarah E Medland3.
Abstract
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.Entities:
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Year: 2015 PMID： 25607358 PMCID： PMC4393366 DOI： 10.1038/nature14101
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962