Literature DB >> 26386953

Development and validation of a FIA/UV-vis method for pK(a) determination of oxime based acetylcholinesterase reactivators.

Karel Musil1, Veronika Florianova2, Pavel Bucek2, Vlastimil Dohnal2, Kamil Kuca1, Kamil Musilek3.   

Abstract

Acetylcholinesterase reactivators (oximes) are compounds used for antidotal treatment in case of organophosphorus poisoning. The dissociation constants (pK(a1)) of ten standard or promising acetylcholinesterase reactivators were determined by ultraviolet absorption spectrometry. Two methods of spectra measurement (UV-vis spectrometry, FIA/UV-vis) were applied and compared. The soft and hard models for calculation of pK(a1) values were performed. The pK(a1) values were recommended in the range 7.00-8.35, where at least 10% of oximate anion is available for organophosphate reactivation. All tested oximes were found to have pK(a1) in this range. The FIA/UV-vis method provided rapid sample throughput, low sample consumption, high sensitivity and precision compared to standard UV-vis method. The hard calculation model was proposed as more accurate for pK(a1) calculation.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  FIA/UV–vis; Organophosphate; Oxime; Reactivator; UV–vis; pK(a)

Mesh：

Substances：

Year:  2015        PMID： 26386953     DOI： 10.1016/j.jpba.2015.09.010

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  5 in total

1.  Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies.

Authors:  Shibaji Ghosh; Nellore Bhanu Chandar; Kalyanashis Jana; Bishwajit Ganguly
Journal:  J Comput Aided Mol Des       Date:  2017-06-23       Impact factor: 3.686

2.  Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates.

Authors:  Hyun Myung Lee; Rudolf Andrys; Jakub Jonczyk; Kyuneun Kim; Avinash G Vishakantegowda; David Malinak; Adam Skarka; Monika Schmidt; Michaela Vaskova; Kamil Latka; Marek Bajda; Young-Sik Jung; Barbara Malawska; Kamil Musilek
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

3.  Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators.

Authors:  Daniel A S Kitagawa; Rafael B Rodrigues; Thiago N Silva; Wellington V Dos Santos; Vinicius C V da Rocha; Joyce S F D de Almeida; Leandro B Bernardo; Taynara Carvalho-Silva; Cintia N Ferreira; Angelo A T da Silva; Alessandro B C Simas; Eugenie Nepovimova; Kamil Kuča; Tanos C C França; Samir F de A Cavalcante
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

Review 4.  Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential.

Authors:  Igor A Schepetkin; Mark B Plotnikov; Andrei I Khlebnikov; Tatiana M Plotnikova; Mark T Quinn
Journal:  Biomolecules       Date:  2021-05-22

5.  New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer's Disease.

Authors:  Kamila Czarnecka; Małgorzata Girek; Przemysław Wójtowicz; Paweł Kręcisz; Robert Skibiński; Jakub Jończyk; Kamil Łątka; Marek Bajda; Anna Walczak; Grzegorz Galita; Jacek Kabziński; Ireneusz Majsterek; Piotr Szymczyk; Paweł Szymański
Journal:  Int J Mol Sci       Date:  2020-05-26       Impact factor: 5.923
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.