| Literature DB >> 26337138 |
Aline Jelenkovic1, Yoshie Yokoyama2, Reijo Sund1, Chika Honda3, Leonie H Bogl4, Sari Aaltonen1, Fuling Ji5, Feng Ning5, Zengchang Pang5, Juan R Ordoñana6, Juan F Sánchez-Romera7, Lucia Colodro-Conde6, S Alexandra Burt8, Kelly L Klump8, Sarah E Medland9, Grant W Montgomery9, Christian Kandler10, Tom A McAdams11, Thalia C Eley11, Alice M Gregory12, Kimberly J Saudino13, Lise Dubois14, Michel Boivin15, Adam D Tarnoki16, David L Tarnoki16, Claire M A Haworth17, Robert Plomin11, Sevgi Y Öncel18, Fazil Aliev19, Maria A Stazi20, Corrado Fagnani20, Cristina D'Ippolito20, Jeffrey M Craig21, Richard Saffery21, Sisira H Siribaddana22, Matthew Hotopf23, Athula Sumathipala22, Fruhling Rijsdijk11, Timothy Spector24, Massimo Mangino24, Genevieve Lachance24, Margaret Gatz25, David A Butler26, Gombojav Bayasgalan27, Danshiitsoodol Narandalai28, Duarte L Freitas29, José Antonio Maia30, K Paige Harden31, Elliot M Tucker-Drob31, Bia Kim32, Youngsook Chong32, Changhee Hong32, Hyun Jung Shin32, Kaare Christensen33, Axel Skytthe33, Kirsten O Kyvik34, Catherine A Derom35, Robert F Vlietinck35, Ruth J F Loos36, Wendy Cozen37, Amie E Hwang37, Thomas M Mack37, Mingguang He38, Xiaohu Ding38, Billy Chang38, Judy L Silberg39, Lindon J Eaves39, Hermine H Maes40, Tessa L Cutler41, John L Hopper41, Kelly Aujard42, Patrik K E Magnusson43, Nancy L Pedersen43, Anna K Dahl Aslan43, Yun-Mi Song44, Sarah Yang45, Kayoung Lee46, Laura A Baker25, Catherine Tuvblad25, Morten Bjerregaard-Andersen47, Henning Beck-Nielsen48, Morten Sodemann49, Kauko Heikkilä4, Qihua Tan50, Dongfeng Zhang51, Gary E Swan52, Ruth Krasnow53, Kerry L Jang54, Ariel Knafo-Noam55, David Mankuta56, Lior Abramson55, Paul Lichtenstein43, Robert F Krueger57, Matt McGue57, Shandell Pahlen57, Per Tynelius58, Glen E Duncan59, Dedra Buchwald59, Robin P Corley60, Brooke M Huibregtse60, Tracy L Nelson61, Keith E Whitfield62, Carol E Franz63, William S Kremen63, Michael J Lyons64, Syuichi Ooki65, Ingunn Brandt66, Thomas Sevenius Nilsen66, Fujio Inui67, Mikio Watanabe3, Meike Bartels68, Toos C E M van Beijsterveldt68, Jane Wardle69, Clare H Llewellyn69, Abigail Fisher69, Esther Rebato70, Nicholas G Martin9, Yoshinori Iwatani3, Kazuo Hayakawa3, Joohon Sung45, Jennifer R Harris66, Gonneke Willemsen68, Andreas Busjahn71, Jack H Goldberg72, Finn Rasmussen58, Yoon-Mi Hur73, Dorret I Boomsma68, Thorkild I A Sørensen74, Jaakko Kaprio4, Karri Silventoinen1.
Abstract
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.Entities:
Keywords: BMI; height; twins; zygosity differences
Mesh：
Year: 2015 PMID： 26337138 PMCID： PMC4605819 DOI： 10.1017/thg.2015.57
Source DB: PubMed Journal: Twin Res Hum Genet ISSN： 1832-4274 Impact factor: 1.587