| Literature DB >> 26313846 |
Derick R White1, Johnathon T Hutt1, John P Wolfe1.
Abstract
A new type of Pd-catalyzed alkene carboamination reaction that provides direct access to enantioenriched 2-aminoindanes from 2-allylphenyltriflate derivatives and aliphatic amines is described. A catalyst generated in situ from Pd(OAc)2 and (S)-tert-butylPHOX provides the functionalized carbocycles in good yield with up to >99:1 er. The transformations occur via a key anti-aminopalladation that involves intermolecular attack of an amine nucleophile on an arylpalladium alkene complex.Entities:
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Year: 2015 PMID： 26313846 PMCID： PMC4934887 DOI： 10.1021/jacs.5b07203
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419