Literature DB >> 26307387

Industry Support of Medical Research: Important Opportunity or Treacherous Pitfall?

William M Tierney1,2, Eric M Meslin3,4, Kurt Kroenke5,3,6.   

Abstract

Pharmaceutical and device manufacturers fund more than half of the medical research in the U.S. Research funding by for-profit companies has increased over the past 20 years, while federal funding has declined. Research funding from for-profit medical companies is seen as tainted by many academicians because of potential biases and prior misbehavior by both investigators and companies. Yet NIH is encouraging partnerships between the public and private sectors to enhance scientific discovery. There are instances, such as methods for improving drug adherence and post-marketing drug surveillance, where the interests of academician researchers and industry could be aligned. We provide examples of ethically performed industry-funded research and a set of principles and benchmarks for ethically credible academic-industry partnerships that could allow academic researchers, for-profit companies, and the public to benefit.

Keywords:  conflict of interest; ethics, research; public–private partnerships; research support

Mesh:

Year:  2015        PMID: 26307387      PMCID: PMC4720652          DOI: 10.1007/s11606-015-3495-z

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  24 in total

1.  Researchers and regulators reflect on first gene therapy death.

Authors:  T Hollon
Journal:  Nat Med       Date:  2000-01       Impact factor: 53.440

Review 2.  Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications.

Authors:  Hans Melander; Jane Ahlqvist-Rastad; Gertie Meijer; Björn Beermann
Journal:  BMJ       Date:  2003-05-31

3.  At issue: A model for academic/industry collaboration.

Authors:  William T Carpenter; James I Koenig; Graeme Bilbe; Serge Bischoff
Journal:  Schizophr Bull       Date:  2004       Impact factor: 9.306

4.  Weight gain and new onset diabetes associated with olanzapine and risperidone.

Authors:  Wildon R Farwell; Timothy E Stump; Jane Wang; Eskinder Tafesse; Gilbert L'Italien; William M Tierney
Journal:  J Gen Intern Med       Date:  2004-12       Impact factor: 5.128

5.  Thyroid storm.

Authors:  D Rennie
Journal:  JAMA       Date:  1997-04-16       Impact factor: 56.272

6.  Justifying conflicts of interest in medical journals: a very bad idea.

Authors:  Robert Steinbrook; Jerome P Kassirer; Marcia Angell
Journal:  BMJ       Date:  2015-06-02

7.  Withholding research results in academic life science. Evidence from a national survey of faculty.

Authors:  D Blumenthal; E G Campbell; M S Anderson; N Causino; K S Louis
Journal:  JAMA       Date:  1997-04-16       Impact factor: 56.272

8.  The PHQ-9: validity of a brief depression severity measure.

Authors:  K Kroenke; R L Spitzer; J B Williams
Journal:  J Gen Intern Med       Date:  2001-09       Impact factor: 5.128

9.  Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial.

Authors:  K Kroenke; S L West; R Swindle; A Gilsenan; G J Eckert; R Dolor; P Stang; X H Zhou; R Hays; M Weinberger
Journal:  JAMA       Date:  2001-12-19       Impact factor: 56.272

10.  The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.

Authors:  C A McHorney; J E Ware; A E Raczek
Journal:  Med Care       Date:  1993-03       Impact factor: 2.983

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  13 in total

1.  Academic-Industry Research Partnerships: an Emerging Opportunity or Just Smoke and Mirrors?

Authors:  Michael Hochman; Rachael Bedard
Journal:  J Gen Intern Med       Date:  2016-02       Impact factor: 5.128

Review 2.  Debates about Conflict of Interest in Medicine: Deconstructing a Divided Discourse.

Authors:  Serena Purdy; Miles Little; Christopher Mayes; Wendy Lipworth
Journal:  J Bioeth Inq       Date:  2017-01-03       Impact factor: 1.352

3.  Pro-Con Perspectives on Ethics in Surgical Research: Update from the 39th Annual Surgical Infection Society Meeting.

Authors:  Vanessa P Ho; Evelyn I Truong; Saira Nisar; Addison K May; Gregory J Beilman; Donald E Fry; Philip S Barie; Jared M Huston; Jeffrey W Shupp; Fredric M Pieracci
Journal:  Surg Infect (Larchmt)       Date:  2020-05       Impact factor: 2.150

4.  Exploring the Influence of Alcohol Industry Funding in Observational Studies on Moderate Alcohol Consumption and Health.

Authors:  Moniek Vos; Annick P M van Soest; Tim van Wingerden; Marion L Janse; Rick M Dijk; Rutger J Brouwer; Iris de Koning; Edith J M Feskens; Aafje Sierksma
Journal:  Adv Nutr       Date:  2020-09-01       Impact factor: 8.701

Review 5.  Ethical challenges in resuscitation.

Authors:  Spyros D Mentzelopoulos; Anne-Marie Slowther; Zoe Fritz; Claudio Sandroni; Theodoros Xanthos; Clifton Callaway; Gavin D Perkins; Craig Newgard; Eleni Ischaki; Robert Greif; Erwin Kompanje; Leo Bossaert
Journal:  Intensive Care Med       Date:  2018-05-10       Impact factor: 17.440

6.  Ten Years of Sports Health: Authorship Characteristics and Levels of Evidence.

Authors:  Ryan P Judy; Spencer Talentino; Asheesh Bedi; Bryson P Lesniak
Journal:  Sports Health       Date:  2020-07-06       Impact factor: 3.843

7.  Using risk of bias domains to identify opportunities for improvement in food- and nutrition-related research: An evaluation of research type and design, year of publication, and source of funding.

Authors:  E F Myers; J S Parrott; P Splett; M Chung; D Handu
Journal:  PLoS One       Date:  2018-07-05       Impact factor: 3.240

8.  Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research.

Authors:  Melanie Goisauf; Gillian Martin; Heidi Beate Bentzen; Isabelle Budin-Ljøsne; Lars Ursin; Anna Durnová; Liis Leitsalu; Katharine Smith; Sara Casati; Marialuisa Lavitrano; Deborah Mascalzoni; Martin Boeckhout; Michaela Th Mayrhofer
Journal:  PLoS One       Date:  2019-09-18       Impact factor: 3.240

Review 9.  [Ethics of resuscitation and end of life decisions].

Authors:  Spyros D Mentzelopoulos; Keith Couper; Patrick Van de Voorde; Patrick Druwé; Marieke Blom; Gavin D Perkins; Ileana Lulic; Jana Djakow; Violetta Raffay; Gisela Lilja; Leo Bossaert
Journal:  Notf Rett Med       Date:  2021-06-02       Impact factor: 0.826

10.  Benchmarks for ethically credible partnerships between industry and academic health centers: beyond disclosure of financial conflicts of interest.

Authors:  Eric M Meslin; Joshua B Rager; Peter H Schwartz; Kimberly A Quaid; Margaret M Gaffney; Jon Duke; William H Tierney
Journal:  Clin Transl Med       Date:  2015-12-14
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