Literature DB >> 26293167

Falsification Testing of Instrumental Variables Methods for Comparative Effectiveness Research.

Steven D Pizer1.   

Abstract

OBJECTIVES: To demonstrate how falsification tests can be used to evaluate instrumental variables methods applicable to a wide variety of comparative effectiveness research questions. STUDY
DESIGN: Brief conceptual review of instrumental variables and falsification testing principles and techniques accompanied by an empirical application. Sample STATA code related to the empirical application is provided in the Appendix. EMPIRICAL APPLICATION: Comparative long-term risks of sulfonylureas and thiazolidinediones for management of type 2 diabetes. Outcomes include mortality and hospitalization for an ambulatory care-sensitive condition. Prescribing pattern variations are used as instrumental variables.
CONCLUSIONS: Falsification testing is an easily computed and powerful way to evaluate the validity of the key assumption underlying instrumental variables analysis. If falsification tests are used, instrumental variables techniques can help answer a multitude of important clinical questions. © Health Research and Educational Trust.

Entities:  

Keywords:  Comparative effectiveness research; big data; causal inference; falsification testing; instrumental variables

Mesh：

Substances：

Year:  2015        PMID： 26293167      PMCID： PMC4799892          DOI： 10.1111/1475-6773.12355

Source DB:  PubMed          Journal:  Health Serv Res        ISSN： 0017-9124            Impact factor:   3.402


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