Literature DB >> 26257442

Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine.

Jaruwan Chatwichien1, Subhasree Basu2, Maureen E Murphy2, Mark T Hamann3, Jeffrey D Winkler1.   

Abstract

The design, synthesis and biological evaluation (anticancer and antimalarial activity) of bis-β-carbolines, based on the structure of the naturally occurring alkaloid neokauluamine, is described.

Entities:  

Keywords:  Manzamine alkaloids; structure-activity relationships (SAR); β-carboline heterocycle

Year:  2015        PMID： 26257442      PMCID： PMC4527524          DOI： 10.1016/j.tetlet.2015.01.142

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  8 in total

1.  Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers.

Authors:  Damien Barbaras; Marcel Kaiser; Reto Brun; Karl Gademann
Journal:  Bioorg Med Chem Lett       Date:  2008-06-19       Impact factor: 2.823

Review 2.  Polyvalency: a promising strategy for drug design.

Authors:  David Vance; Mrinal Shah; Amit Joshi; Ravi S Kane
Journal:  Biotechnol Bioeng       Date:  2008-10-15       Impact factor: 4.530

3.  New manzamine alkaloids with potent activity against infectious diseases.

Authors:  K A El Sayed; M Kelly; U A Kara; K K Ang; I Katsuyama; D C Dunbar; A A Khan; M T Hamann
Journal:  J Am Chem Soc       Date:  2001-03-07       Impact factor: 15.419

4.  Synthesis and biological studies of 1-amino beta-carbolines.

Authors:  Yohan Boursereau; Iain Coldham
Journal:  Bioorg Med Chem Lett       Date:  2004-12-06       Impact factor: 2.823

Review 5.  beta-Carboline alkaloids: biochemical and pharmacological functions.

Authors:  Rihui Cao; Wenlie Peng; Zihou Wang; Anlong Xu
Journal:  Curr Med Chem       Date:  2007       Impact factor: 4.530

6.  Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.

Authors:  Karumanchi V Rao; Noer Kasanah; Subagus Wahyuono; Babu L Tekwani; Raymond F Schinazi; Mark T Hamann
Journal:  J Nat Prod       Date:  2004-08       Impact factor: 4.050

7.  Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.

Authors:  Rachid Skouta; Miki Hayano; Kenichi Shimada; Brent R Stockwell
Journal:  Bioorg Med Chem Lett       Date:  2012-06-30       Impact factor: 2.823

8.  Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

Authors:  Quentin McAfee; Zhihui Zhang; Arabinda Samanta; Samuel M Levi; Xiao-Hong Ma; Shengfu Piao; John P Lynch; Takeshi Uehara; Antonia R Sepulveda; Lisa E Davis; Jeffrey D Winkler; Ravi K Amaravadi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-07       Impact factor: 11.205
  8 in total
  2 in total

1.  Reaction between harmaline and vanillin to produce dimeric scaffoldsthat exhibit anti-proliferative activity.

Authors:  Vishal C Birar; Gene Zaid; Brian S J Blagg
Journal:  Tetrahedron Lett       Date:  2021-05-01       Impact factor: 2.032

2.  PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.

Authors:  Jaruwan Chatwichien; Subhasree Basu; Anna Budina-Kolomets; Maureen E Murphy; Jeffrey D Winkler
Journal:  Bioorg Med Chem Lett       Date:  2016-09-13       Impact factor: 2.823
  2 in total

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