Literature DB >> 27650927

PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.

Jaruwan Chatwichien1, Subhasree Basu2, Anna Budina-Kolomets2, Maureen E Murphy2, Jeffrey D Winkler1.   

Abstract

Dimeric β-carbolines are cytotoxic against multiple NSCLC cell lines, and we report herein our preliminary studies on the mechanism of action of these dimeric structures. Dimeric β-carboline 1, which is more potent than the corresponding monomer in NSCLC cell lines, is a lysosomotropic agent that inhibits autophagy and mediates cell death by apoptosis, upregulating the pro-apoptotic BH3-only protein PUMA (p53 upregulated modulator of apoptosis) in a dose dependent manner.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Apoptosis; Autophagy; Lysosomotropic; PUMA; β-Carboline dimer

Mesh：

Substances：

Year:  2016        PMID： 27650927      PMCID： PMC5464723          DOI： 10.1016/j.bmcl.2016.09.030

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  22 in total

1.  Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.

Authors:  Jacqueline Thorburn; Zdenek Andrysik; Leah Staskiewicz; Jacob Gump; Paola Maycotte; Andrew Oberst; Douglas R Green; Joaquín M Espinosa; Andrew Thorburn
Journal:  Cell Rep       Date:  2014-03-27       Impact factor: 9.423

Review 2.  Crosstalk between autophagy and apoptosis in heart disease.

Authors:  Kazuhiko Nishida; Osamu Yamaguchi; Kinya Otsu
Journal:  Circ Res       Date:  2008-08-15       Impact factor: 17.367

Review 3.  Lysosomal membrane permeabilization in cell death.

Authors:  P Boya; G Kroemer
Journal:  Oncogene       Date:  2008-10-27       Impact factor: 9.867

4.  Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs.

Authors:  Y Wang; G Blandino; M Oren; D Givol
Journal:  Oncogene       Date:  1998-10-15       Impact factor: 9.867

Review 5.  Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death.

Authors:  Ana M Villamil Giraldo; Hanna Appelqvist; Thomas Ederth; Karin Öllinger
Journal:  Biochem Soc Trans       Date:  2014-10       Impact factor: 5.407

Review 6.  Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy.

Authors:  Ana Vanessa Nascimento; Hassan Bousbaa; Domingos Ferreira; Bruno Sarmento
Journal:  Curr Drug Targets       Date:  2015       Impact factor: 3.465

7.  Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.

Authors:  Quentin McAfee; Zhihui Zhang; Arabinda Samanta; Samuel M Levi; Xiao-Hong Ma; Shengfu Piao; John P Lynch; Takeshi Uehara; Antonia R Sepulveda; Lisa E Davis; Jeffrey D Winkler; Ravi K Amaravadi
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-07       Impact factor: 11.205

Review 8.  Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:  Daniel J Klionsky; Hagai Abeliovich; Patrizia Agostinis; Devendra K Agrawal; Gjumrakch Aliev; David S Askew; Misuzu Baba; Eric H Baehrecke; Ben A Bahr; Andrea Ballabio; Bruce A Bamber; Diane C Bassham; Ettore Bergamini; Xiaoning Bi; Martine Biard-Piechaczyk; Janice S Blum; Dale E Bredesen; Jeffrey L Brodsky; John H Brumell; Ulf T Brunk; Wilfried Bursch; Nadine Camougrand; Eduardo Cebollero; Francesco Cecconi; Yingyu Chen; Lih-Shen Chin; Augustine Choi; Charleen T Chu; Jongkyeong Chung; Peter G H Clarke; Robert S B Clark; Steven G Clarke; Corinne Clavé; John L Cleveland; Patrice Codogno; María I Colombo; Ana Coto-Montes; James M Cregg; Ana Maria Cuervo; Jayanta Debnath; Francesca Demarchi; Patrick B Dennis; Phillip A Dennis; Vojo Deretic; Rodney J Devenish; Federica Di Sano; J Fred Dice; Marian Difiglia; Savithramma Dinesh-Kumar; Clark W Distelhorst; Mojgan Djavaheri-Mergny; Frank C Dorsey; Wulf Dröge; Michel Dron; William A Dunn; Michael Duszenko; N Tony Eissa; Zvulun Elazar; Audrey Esclatine; Eeva-Liisa Eskelinen; László Fésüs; Kim D Finley; José M Fuentes; Juan Fueyo; Kozo Fujisaki; Brigitte Galliot; Fen-Biao Gao; David A Gewirtz; Spencer B Gibson; Antje Gohla; Alfred L Goldberg; Ramon Gonzalez; Cristina González-Estévez; Sharon Gorski; Roberta A Gottlieb; Dieter Häussinger; You-Wen He; Kim Heidenreich; Joseph A Hill; Maria Høyer-Hansen; Xun Hu; Wei-Pang Huang; Akiko Iwasaki; Marja Jäättelä; William T Jackson; Xuejun Jiang; Shengkan Jin; Terje Johansen; Jae U Jung; Motoni Kadowaki; Chanhee Kang; Ameeta Kelekar; David H Kessel; Jan A K W Kiel; Hong Pyo Kim; Adi Kimchi; Timothy J Kinsella; Kirill Kiselyov; Katsuhiko Kitamoto; Erwin Knecht; Masaaki Komatsu; Eiki Kominami; Seiji Kondo; Attila L Kovács; Guido Kroemer; Chia-Yi Kuan; Rakesh Kumar; Mondira Kundu; Jacques Landry; Marianne Laporte; Weidong Le; Huan-Yao Lei; Michael J Lenardo; Beth Levine; Andrew Lieberman; Kah-Leong Lim; Fu-Cheng Lin; Willisa Liou; Leroy F Liu; Gabriel Lopez-Berestein; Carlos López-Otín; Bo Lu; Kay F Macleod; Walter Malorni; Wim Martinet; Ken Matsuoka; Josef Mautner; Alfred J Meijer; Alicia Meléndez; Paul Michels; Giovanni Miotto; Wilhelm P Mistiaen; Noboru Mizushima; Baharia Mograbi; Iryna Monastyrska; Michael N Moore; Paula I Moreira; Yuji Moriyasu; Tomasz Motyl; Christian Münz; Leon O Murphy; Naweed I Naqvi; Thomas P Neufeld; Ichizo Nishino; Ralph A Nixon; Takeshi Noda; Bernd Nürnberg; Michinaga Ogawa; Nancy L Oleinick; Laura J Olsen; Bulent Ozpolat; Shoshana Paglin; Glen E Palmer; Issidora Papassideri; Miles Parkes; David H Perlmutter; George Perry; Mauro Piacentini; Ronit Pinkas-Kramarski; Mark Prescott; Tassula Proikas-Cezanne; Nina Raben; Abdelhaq Rami; Fulvio Reggiori; Bärbel Rohrer; David C Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Hiroshi Sakagami; Yasuyoshi Sakai; Marco Sandri; Chihiro Sasakawa; Miklós Sass; Claudio Schneider; Per O Seglen; Oleksandr Seleverstov; Jeffrey Settleman; John J Shacka; Irving M Shapiro; Andrei Sibirny; Elaine C M Silva-Zacarin; Hans-Uwe Simon; Cristiano Simone; Anne Simonsen; Mark A Smith; Katharina Spanel-Borowski; Vickram Srinivas; Meredith Steeves; Harald Stenmark; Per E Stromhaug; Carlos S Subauste; Seiichiro Sugimoto; David Sulzer; Toshihiko Suzuki; Michele S Swanson; Ira Tabas; Fumihiko Takeshita; Nicholas J Talbot; Zsolt Tallóczy; Keiji Tanaka; Kozo Tanaka; Isei Tanida; Graham S Taylor; J Paul Taylor; Alexei Terman; Gianluca Tettamanti; Craig B Thompson; Michael Thumm; Aviva M Tolkovsky; Sharon A Tooze; Ray Truant; Lesya V Tumanovska; Yasuo Uchiyama; Takashi Ueno; Néstor L Uzcátegui; Ida van der Klei; Eva C Vaquero; Tibor Vellai; Michael W Vogel; Hong-Gang Wang; Paul Webster; John W Wiley; Zhijun Xi; Gutian Xiao; Joachim Yahalom; Jin-Ming Yang; George Yap; Xiao-Ming Yin; Tamotsu Yoshimori; Li Yu; Zhenyu Yue; Michisuke Yuzaki; Olga Zabirnyk; Xiaoxiang Zheng; Xiongwei Zhu; Russell L Deter
Journal:  Autophagy       Date:  2007-11-21       Impact factor: 16.016

9.  PUMA- and Bax-induced autophagy contributes to apoptosis.

Authors:  K S Yee; S Wilkinson; J James; K M Ryan; K H Vousden
Journal:  Cell Death Differ       Date:  2009-03-20       Impact factor: 15.828

10.  Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells.

Authors:  Yushu Ruan; Ke Hu; Hongbo Chen
Journal:  Mol Med Rep       Date:  2015-07-29       Impact factor: 2.952
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  2 in total

Review 1.  Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets.

Authors:  Rui Qin; Feng-Ming You; Qian Zhao; Xin Xie; Cheng Peng; Gu Zhan; Bo Han
Journal:  J Hematol Oncol       Date:  2022-09-14       Impact factor: 23.168

2.  Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis.

Authors:  Hyun-Ju Yu; Chi-Hyun Ahn; In-Hyoung Yang; Dong-Hoon Won; Bohwan Jin; Nam-Pyo Cho; Seong Doo Hong; Ji-Ae Shin; Sung-Dae Cho
Journal:  Mol Med Rep       Date:  2018-01-22       Impact factor: 2.952
  2 in total

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