Literature DB >> 18606541

Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers.

Damien Barbaras1, Marcel Kaiser, Reto Brun, Karl Gademann.   

Abstract

The quaternary beta-carbolinium alkaloid nostocarboline from the cyanobacterium Nostoc 78-12A and 10 bis-cationic dimeric derivatives were evaluated against four protozoan parasites and low micromolar values against Trypanosoma brucei, submicromolar values against Leishmania donovani and low nanomolar values against Plasmodium falciparum K1 were determined. Selectivity against rat myoblasts (L6 cells) was found to be up to >2500-fold.

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Year:  2008        PMID： 18606541     DOI： 10.1016/j.bmcl.2008.06.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.

Authors:  George E Chlipala; Shunyan Mo; Jimmy Orjala
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

Review 2.  The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules.

Authors:  Katharine R Watts; Karen Tenney; Phillip Crews
Journal:  Curr Opin Biotechnol       Date:  2010-10-16       Impact factor: 9.740

3.  Beta-carboline-3-carboxamide derivatives as promising antileishmanial agents.

Authors:  R B Pedroso; L T D Tonin; T Ueda-Nakamura; B P Dias Filho; M H Sarragiotto; C V Nakamura
Journal:  Ann Trop Med Parasitol       Date:  2011-12

4.  Antimalarial Natural Products.

Authors:  David G I Kingston; Maria Belen Cassera
Journal:  Prog Chem Org Nat Prod       Date:  2022

5.  Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine.

Authors:  Jaruwan Chatwichien; Subhasree Basu; Maureen E Murphy; Mark T Hamann; Jeffrey D Winkler
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

Review 6.  Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects.

Authors:  Rachana Singh; Parul Parihar; Madhulika Singh; Andrzej Bajguz; Jitendra Kumar; Samiksha Singh; Vijay P Singh; Sheo M Prasad
Journal:  Front Microbiol       Date:  2017-04-25       Impact factor: 5.640

7.  SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents.

Authors:  Maja Beus; Zrinka Rajić; Dusica Maysinger; Zvonimir Mlinarić; Maja Antunović; Inga Marijanović; Diana Fontinha; Miguel Prudêncio; Jana Held; Sureyya Olgen; Branka Zorc
Journal:  ChemistryOpen       Date:  2018-08-21       Impact factor: 2.911

Review 8.  Phycochemistry and bioactivity of cyanobacterial secondary metabolites.

Authors:  Rupanshee Srivastava; Rajesh Prajapati; Tripti Kanda; Sadhana Yadav; Nidhi Singh; Shivam Yadav; Rajeev Mishra; Neelam Atri
Journal:  Mol Biol Rep       Date:  2022-09-26       Impact factor: 2.742
  8 in total

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