Literature DB >> 15501052

Synthesis and biological studies of 1-amino beta-carbolines.

Yohan Boursereau1, Iain Coldham.   

Abstract

A selection of 1-amino-substituted beta-carbolines have been prepared by amination of 1-chloro-beta-carboline as simple mimics of manzamine A and chloroquine and their intercalating ability, anticancer and antimalarial activity were studied.

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Year:  2004        PMID： 15501052     DOI： 10.1016/j.bmcl.2004.09.036

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  A spectroscopic study of the interaction of the fluorescent beta-carboline-3-carboxylic acid N-methylamide with DNA constituents: nucleobases, nucleosides and nucleotides.

Authors:  Iñigo X García-Zubiri; Hugh D Burrows; Joao S Seixas de Melo; María Monteserín; Antonio Arroyo; María J Tapia
Journal:  J Fluoresc       Date:  2008-05-11       Impact factor: 2.217

2.  Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation.

Authors:  Kunal Kumar; Peng Wang; Roberto Sanchez; Ethan A Swartz; Andrew F Stewart; Robert J DeVita
Journal:  J Med Chem       Date:  2018-08-21       Impact factor: 7.446

3.  Room-temperature aromatization of tetrahydro-β-carbolines by 2-iodoxybenzoic acid: utility in a total synthesis of eudistomin U.

Authors:  Joseph D Panarese; Stephen P Waters
Journal:  Org Lett       Date:  2010-09-17       Impact factor: 6.005

4.  Beta-carboline-3-carboxamide derivatives as promising antileishmanial agents.

Authors:  R B Pedroso; L T D Tonin; T Ueda-Nakamura; B P Dias Filho; M H Sarragiotto; C V Nakamura
Journal:  Ann Trop Med Parasitol       Date:  2011-12

5.  Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine.

Authors:  Jaruwan Chatwichien; Subhasree Basu; Maureen E Murphy; Mark T Hamann; Jeffrey D Winkler
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

6.  Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b]indole Derivatives as Broad-Spectrum Potent Anticancer Agents.

Authors:  Shivaputra A Patil; James K Addo; Hemantkumar Deokar; Shan Sun; Jin Wang; Wei Li; D Parker Suttle; Wei Wang; Ruiwen Zhang; John K Buolamwini
Journal:  Drug Des       Date:  2017-03-01

7.  Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6-endo cationic π-cyclization.

Authors:  Piyush Kumar Agarwal; Meena Devi Dathi; Mohammad Saifuddin; Bijoy Kundu
Journal:  Beilstein J Org Chem       Date:  2012-11-08       Impact factor: 2.883

8.  The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro- β -carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction.

Authors:  Hélito Volpato; Vânia Cristina Desoti; Juliana Cogo; Manuela Ribeiro Panice; Maria Helena Sarragiotto; Sueli de Oliveira Silva; Tânia Ueda-Nakamura; Celso Vataru Nakamura
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-13       Impact factor: 2.629
  8 in total

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