Literature DB >> 26196764

The promise and peril of chemical probes.

Cheryl H Arrowsmith1, James E Audia2, Christopher Austin3, Jonathan Baell4, Jonathan Bennett5, Julian Blagg6, Chas Bountra7, Paul E Brennan8, Peter J Brown9, Mark E Bunnage10, Carolyn Buser-Doepner11, Robert M Campbell12, Adrian J Carter13, Philip Cohen14, Robert A Copeland15, Ben Cravatt16, Jayme L Dahlin17, Dashyant Dhanak18, Aled M Edwards9, Mathias Frederiksen19, Stephen V Frye20, Nathanael Gray21, Charles E Grimshaw22, David Hepworth10, Trevor Howe23, Kilian V M Huber24, Jian Jin25, Stefan Knapp8, Joanne D Kotz26, Ryan G Kruger27, Derek Lowe28, Mary M Mader12, Brian Marsden7, Anke Mueller-Fahrnow29, Susanne Müller8, Ronan C O'Hagan30, John P Overington31, Dafydd R Owen10, Saul H Rosenberg32, Bryan Roth33, Brian Roth34, Ruth Ross35, Matthieu Schapira36, Stuart L Schreiber26, Brian Shoichet37, Michael Sundström38, Giulio Superti-Furga39, Jack Taunton40, Leticia Toledo-Sherman41, Chris Walpole42, Michael A Walters43, Timothy M Willson44, Paul Workman6, Robert N Young45, William J Zuercher44.   

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Year:  2015        PMID: 26196764      PMCID: PMC4706458          DOI: 10.1038/nchembio.1867

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN: 1552-4450            Impact factor:   15.040


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  38 in total

1.  Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Authors:  William A Weiss; Stephen S Taylor; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2007-12       Impact factor: 15.040

2.  Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Authors:  Daniel Martinez Molina; Rozbeh Jafari; Marina Ignatushchenko; Takahiro Seki; E Andreas Larsson; Chen Dan; Lekshmy Sreekumar; Yihai Cao; Pär Nordlund
Journal:  Science       Date:  2013-07-05       Impact factor: 47.728

3.  Too many roads not taken.

Authors:  Aled M Edwards; Ruth Isserlin; Gary D Bader; Stephen V Frye; Timothy M Willson; Frank H Yu
Journal:  Nature       Date:  2011-02-10       Impact factor: 49.962

Review 4.  Targeting bromodomains: epigenetic readers of lysine acetylation.

Authors:  Panagis Filippakopoulos; Stefan Knapp
Journal:  Nat Rev Drug Discov       Date:  2014-04-22       Impact factor: 84.694

Review 5.  Recently targeted kinases and their inhibitors-the path to clinical trials.

Authors:  Stefan Knapp; Michael Sundström
Journal:  Curr Opin Pharmacol       Date:  2014-08-09       Impact factor: 5.547

6.  Chemistry: Chemical con artists foil drug discovery.

Authors:  Jonathan Baell; Michael A Walters
Journal:  Nature       Date:  2014-09-25       Impact factor: 49.962

7.  Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

Authors:  M Göttlicher; S Minucci; P Zhu; O H Krämer; A Schimpf; S Giavara; J P Sleeman; F Lo Coco; C Nervi; P G Pelicci; T Heinzel
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

8.  Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

Authors:  Dorothea Greiner; Tiziana Bonaldi; Ragnhild Eskeland; Ernst Roemer; Axel Imhof
Journal:  Nat Chem Biol       Date:  2005-07-17       Impact factor: 15.040

9.  Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Authors:  Kay Ahn; Sarah E Smith; Marya B Liimatta; David Beidler; Nalini Sadagopan; David T Dudley; Tim Young; Paul Wren; Yanhua Zhang; Steven Swaney; Keri Van Becelaere; Jacqueline L Blankman; Daniel K Nomura; Shobha N Bhattachar; Cory Stiff; Tyzoon K Nomanbhoy; Eranthie Weerapana; Douglas S Johnson; Benjamin F Cravatt
Journal:  J Pharmacol Exp Ther       Date:  2011-04-19       Impact factor: 4.030

10.  SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Authors:  Michelle Pacholec; John E Bleasdale; Boris Chrunyk; David Cunningham; Declan Flynn; Robert S Garofalo; David Griffith; Matt Griffor; Pat Loulakis; Brandon Pabst; Xiayang Qiu; Brian Stockman; Venkataraman Thanabal; Alison Varghese; Jessica Ward; Jane Withka; Kay Ahn
Journal:  J Biol Chem       Date:  2010-01-08       Impact factor: 5.157

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  258 in total

1.  Tackling reproducibility in academic preclinical drug discovery.

Authors:  Stephen V Frye; Michelle R Arkin; Cheryl H Arrowsmith; P Jeffrey Conn; Marcie A Glicksman; Emily A Hull-Ryde; Barbara S Slusher
Journal:  Nat Rev Drug Discov       Date:  2015-09-21       Impact factor: 84.694

2.  Chemical modulators of ribosome biogenesis as biological probes.

Authors:  Jonathan M Stokes; Eric D Brown
Journal:  Nat Chem Biol       Date:  2015-11-17       Impact factor: 15.040

3.  Targeting Pim Kinases and DAPK3 to Control Hypertension.

Authors:  David A Carlson; Miriam R Singer; Cindy Sutherland; Clara Redondo; Leila T Alexander; Philip F Hughes; Stefan Knapp; Susan B Gurley; Matthew A Sparks; Justin A MacDonald; Timothy A J Haystead
Journal:  Cell Chem Biol       Date:  2018-07-19       Impact factor: 8.116

4.  ALARM NMR for HTS triage and chemical probe validation.

Authors:  Jayme L Dahlin; Matthew Cuellar; Gurpreet Singh; Kathryn M Nelson; Jessica Strasser; Todd Rappe; Youlin Xia; Gianluigi Veglia; Michael A Walters
Journal:  Curr Protoc Chem Biol       Date:  2018-04-09

5.  Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4).

Authors:  Mykhaylo S Frasinyuk; Wen Zhang; Przemyslaw Wyrebek; Tianxin Yu; Xuehe Xu; Vitaliy M Sviripa; Svitlana P Bondarenko; Yanqi Xie; Huy X Ngo; Andrew J Morris; James L Mohler; Michael V Fiandalo; David S Watt; Chunming Liu
Journal:  Org Biomol Chem       Date:  2017-09-20       Impact factor: 3.876

Review 6.  Natural products as modulators of eukaryotic protein secretion.

Authors:  Hendrik Luesch; Ville O Paavilainen
Journal:  Nat Prod Rep       Date:  2020-02-18       Impact factor: 13.423

7.  Metal-binding effects of sirtuin inhibitor sirtinol.

Authors:  Eman A Akam; Ritika Gautam; Elisa Tomat
Journal:  Supramol Chem       Date:  2015-10-15       Impact factor: 1.688

8.  Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.

Authors:  Prson Gautam; Alok Jaiswal; Tero Aittokallio; Hassan Al-Ali; Krister Wennerberg
Journal:  Cell Chem Biol       Date:  2019-05-02       Impact factor: 8.116

9.  Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

Authors:  Cecilia Lopez-Sambrooks; Shiteshu Shrimal; Carol Khodier; Daniel P Flaherty; Natalie Rinis; Jonathan C Charest; Ningguo Gao; Peng Zhao; Lance Wells; Timothy A Lewis; Mark A Lehrman; Reid Gilmore; Jennifer E Golden; Joseph N Contessa
Journal:  Nat Chem Biol       Date:  2016-10-03       Impact factor: 15.040

10.  Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice.

Authors:  Amel Dudakovic; Emily T Camilleri; Scott M Riester; Christopher R Paradise; Martina Gluscevic; Thomas M O'Toole; Roman Thaler; Jared M Evans; Huihuang Yan; Malayannan Subramaniam; John R Hawse; Gary S Stein; Martin A Montecino; Meghan E McGee-Lawrence; Jennifer J Westendorf; Andre J van Wijnen
Journal:  J Biol Chem       Date:  2016-10-10       Impact factor: 5.157

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