Literature DB >> 25254460

Chemistry: Chemical con artists foil drug discovery.

Jonathan Baell, Michael A Walters.   

Abstract

Mesh：

Year:  2014        PMID： 25254460     DOI： 10.1038/513481a

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  8 in total

1.  Observations on screening-based research and some concerning trends in the literature.

Authors:  Jonathan B Baell
Journal:  Future Med Chem       Date:  2010-10       Impact factor: 3.808

2.  New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

Authors:  Jonathan B Baell; Georgina A Holloway
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

3.  What is the likelihood of an active compound to be promiscuous? Systematic assessment of compound promiscuity on the basis of PubChem confirmatory bioassay data.

Authors:  Ye Hu; Jürgen Bajorath
Journal:  AAPS J       Date:  2013-04-19       Impact factor: 4.009

Review 4.  The essential roles of chemistry in high-throughput screening triage.

Authors:  Jayme L Dahlin; Michael A Walters
Journal:  Future Med Chem       Date:  2014-07       Impact factor: 3.808

5.  Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.

Authors:  Matthew E Voss; Percy H Carter; Andrew J Tebben; Peggy A Scherle; Gregory D Brown; Lorin A Thompson; Meizhong Xu; Yvonne C Lo; Gengjie Yang; Rui-Qin Liu; Paul Strzemienski; J Gerry Everlof; James M Trzaskos; Carl P Decicco
Journal:  Bioorg Med Chem Lett       Date:  2003-02-10       Impact factor: 2.823

6.  Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.

Authors:  Chinnasamy Ramesh; Tapan K Nayak; Ritwik Burai; Megan K Dennis; Helen J Hathaway; Larry A Sklar; Eric R Prossnitz; Jeffrey B Arterburn
Journal:  J Med Chem       Date:  2010-02-11       Impact factor: 7.446

Review 7.  Chemical and structural features influencing the biological activity of curcumin.

Authors:  K Indira Priyadarsini
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

8.  Phytochemicals perturb membranes and promiscuously alter protein function.

Authors:  Helgi I Ingólfsson; Pratima Thakur; Karl F Herold; E Ashley Hobart; Nicole B Ramsey; Xavier Periole; Djurre H de Jong; Martijn Zwama; Duygu Yilmaz; Katherine Hall; Thorsten Maretzky; Hugh C Hemmings; Carl Blobel; Siewert J Marrink; Armağan Koçer; Jon T Sack; Olaf S Andersen
Journal:  ACS Chem Biol       Date:  2014-06-17       Impact factor: 5.100
  8 in total
  287 in total

1.  Tackling reproducibility in academic preclinical drug discovery.

Authors:  Stephen V Frye; Michelle R Arkin; Cheryl H Arrowsmith; P Jeffrey Conn; Marcie A Glicksman; Emily A Hull-Ryde; Barbara S Slusher
Journal:  Nat Rev Drug Discov       Date:  2015-09-21       Impact factor: 84.694

2.  How to Triage PAINS-Full Research.

Authors:  Jayme L Dahlin; Michael A Walters
Journal:  Assay Drug Dev Technol       Date:  2015-10-23       Impact factor: 1.738

Review 3.  Small Molecule Inhibitors of Protein Arginine Methyltransferases.

Authors:  Hao Hu; Kun Qian; Meng-Chiao Ho; Y George Zheng
Journal:  Expert Opin Investig Drugs       Date:  2016-02-16       Impact factor: 6.206

4.  Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

Authors:  Margaret E Olson; Daniel Abate-Pella; Angela L Perkins; Ming Li; Michael A Carpenter; Anurag Rathore; Reuben S Harris; Daniel A Harki
Journal:  J Med Chem       Date:  2015-09-11       Impact factor: 7.446

5.  Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.

Authors:  Travis R Helgren; Congling Chen; Phumvadee Wangtrakuldee; Thomas E Edwards; Bart L Staker; Jan Abendroth; Banumathi Sankaran; Nicole A Housley; Peter J Myler; Jonathon P Audia; James R Horn; Timothy J Hagen
Journal:  Bioorg Med Chem       Date:  2016-11-10       Impact factor: 3.641

6.  pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.

Authors:  Philip G Penketh; Richard A Finch; Rachel Sauro; Raymond P Baumann; Elena S Ratner; Krishnamurthy Shyam
Journal:  Chem Biol Drug Des       Date:  2017-07-17       Impact factor: 2.817

7.  Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.

Authors:  Sean Ekins; Nadia K Litterman; Christopher A Lipinski; Barry A Bunin
Journal:  Pharm Res       Date:  2015-08-27       Impact factor: 4.200

8.  Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

Authors:  Jayme L Dahlin; J Willem M Nissink; Subhashree Francis; Jessica M Strasser; Kristen John; Zhiguo Zhang; Michael A Walters
Journal:  Bioorg Med Chem Lett       Date:  2015-08-10       Impact factor: 2.823

9.  Metal-binding effects of sirtuin inhibitor sirtinol.

Authors:  Eman A Akam; Ritika Gautam; Elisa Tomat
Journal:  Supramol Chem       Date:  2015-10-15       Impact factor: 1.688

10.  Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Authors:  Jason M Rohde; Kyle R Brimacombe; Li Liu; Michael E Pacold; Adam Yasgar; Dorian M Cheff; Tobie D Lee; Ganesha Rai; Bolormaa Baljinnyam; Zhuyin Li; Anton Simeonov; Matthew D Hall; Min Shen; David M Sabatini; Matthew B Boxer
Journal:  Bioorg Med Chem       Date:  2018-02-27       Impact factor: 3.641
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