Heidi Weberruß1, Raphael Pirzer2, Birgit Böhm3, Julia Elmenhorst3, Robert Dalla Pozza2, Heinrich Netz2, Renate Oberhoffer3. 1. Institute of Preventive Pediatrics, Technische Universität München, Munich, Germany. Electronic address: heidi.weberruss@tum.de. 2. Department of Pediatric Cardiology, Ludwig-Maximilians-University, Munich, Germany. 3. Institute of Preventive Pediatrics, Technische Universität München, Munich, Germany.
Abstract
OBJECTIVE: Subclinical atherosclerosis can be assessed via sonographic measurement of intima-media thickness and carotid artery distensibility, both may already be pathologically altered in childhood. Therefore, the purpose of this study was to provide reference percentiles and investigate possible associations between alterations of intima-media thickness and distensibility. METHODS: Carotid intima-media thickness and distensibility was measured via B- and M-mode ultrasound. Distensibility was defined by arterial compliance, elastic modulus, stiffness parameter β, and local pulse wave velocity β. Age- and height-dependent reference values were calculated separately for boys and girls among 690 (intima-media thickness) and 870 (distensibility) non-obese children aged 7-17 years. RESULTS: Intima-media thickness and distensibility did not increase significantly with age or differ between boys and girls. Systolic blood pressure and body mass index were independent predictors of intima-media thickness, while an increased systolic blood pressure or pulse pressure was associated with stiffer arteries. Increased intima-media thickness was accompanied by higher arterial compliance and lower stiffness. CONCLUSION: Using this healthy cohort, we describe a functional and non-pathological arterial adaptation wherein an increase in intima-media thickness is not associated with stiffer arteries.
OBJECTIVE: Subclinical atherosclerosis can be assessed via sonographic measurement of intima-media thickness and carotid artery distensibility, both may already be pathologically altered in childhood. Therefore, the purpose of this study was to provide reference percentiles and investigate possible associations between alterations of intima-media thickness and distensibility. METHODS: Carotid intima-media thickness and distensibility was measured via B- and M-mode ultrasound. Distensibility was defined by arterial compliance, elastic modulus, stiffness parameter β, and local pulse wave velocity β. Age- and height-dependent reference values were calculated separately for boys and girls among 690 (intima-media thickness) and 870 (distensibility) non-obesechildren aged 7-17 years. RESULTS: Intima-media thickness and distensibility did not increase significantly with age or differ between boys and girls. Systolic blood pressure and body mass index were independent predictors of intima-media thickness, while an increased systolic blood pressure or pulse pressure was associated with stiffer arteries. Increased intima-media thickness was accompanied by higher arterial compliance and lower stiffness. CONCLUSION: Using this healthy cohort, we describe a functional and non-pathological arterial adaptation wherein an increase in intima-media thickness is not associated with stiffer arteries.
Authors: Allen R Yu; Bima Hasjim; Luke E Yu; Christopher Gabriel; Alexander Anshus; Jonathan B Lee; Michael J Louthan; Esther C Kim; Katrina Lee; Christina Tse; Thomas Keown; Shadi Lahham; Maili Alvarado; Steven Bunch; Abdulatif Gari; J Christian Fox Journal: World J Emerg Med Date: 2017
Authors: Luiz Rodrigo Augustemak de Lima; Edio Luiz Petroski; Yara Maria Franco Moreno; Diego Augusto Santos Silva; Erasmo Benício de Moraes Santos Trindade; Aroldo Prohmann de Carvalho; Isabela de Carlos Back Journal: PLoS One Date: 2018-01-10 Impact factor: 3.240
Authors: Julia Elmenhorst; Heidi Weberruss; Martina Mayr; Karin Pfister; Renate Oberhoffer Journal: Front Pediatr Date: 2019-08-20 Impact factor: 3.418