| Literature DB >> 26177215 |
Hongyang Sun1, Meixian Liu2, Zongtao Lin3, Haixiu Jiang2, Yanyan Niu2, Hong Wang2, Shizhong Chen4.
Abstract
A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang-huang-lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula.Entities:
Keywords: Flavonoids; HPLC-DAD-ESI-IT-TOF-MS; Iridoid glycosides; Phenolic acids; Phenylethanoid glycosides; Shuang–huang–lian powder injection
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Year: 2015 PMID： 26177215 DOI： 10.1016/j.jpba.2015.06.013
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935