Literature DB >> 26165203

A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp. and its cytotoxic activity.

Huawei Zhang1,2, Steven T Loveridge2, Karen Tenney2, Phillip Crews2.   

Abstract

A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (1), was isolated from the methanol extract of an Indonesia marine sponge Haliclona sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound 1 had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC50 values of 41.8, 48.4 and 33.2 μM, respectively.

Entities:  

Keywords:  3-alkylpyridine; Haliclona sp.; alkaloid; cytotoxicity

Mesh：

Substances：

Year:  2015        PMID： 26165203      PMCID： PMC5182040          DOI： 10.1080/14786419.2015.1054826

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  6 in total

1.  Chemical and pharmacological characterization of halitoxin from Amphimedon viridis (Porifera) from the southeastern Brazilian coast.

Authors:  R G Berlinck; C A Ogawa; A M Almeida; M A Sanchez; E L Malpezzi; L V Costa; E Hajdu; J C de Freitas
Journal:  Comp Biochem Physiol C Pharmacol Toxicol Endocrinol       Date:  1996-10

2.  Pyrinadines B-G, new bis-pyridine alkaloids with an azoxy moiety from sponge Cribrochalina sp.

Authors:  Yuuko Kariya; Takaaki Kubota; Jane Fromont; Jun'ichi Kobayashi
Journal:  Bioorg Med Chem       Date:  2006-09-25       Impact factor: 3.641

3.  Viscosalines B(1,2) and E(1,2): challenging new 3-alkyl pyridinium alkaloids from the marine sponge Haliclona viscosa.

Authors:  Gesine Schmidt; Christoph Timm; Achim Grube; Christian A Volk; Matthias Köck
Journal:  Chemistry       Date:  2012-05-21       Impact factor: 5.236

4.  Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.

Authors:  Naoya Oku; Koji Nagai; Nobuaki Shindoh; Yoh Terada; Rob W M van Soest; Shigeki Matsunaga; Nobuhiro Fusetani
Journal:  Bioorg Med Chem Lett       Date:  2004-05-17       Impact factor: 2.823

5.  Viscosamine: the first naturally occurring trimeric 3-alkyl pyridinium alkaloid.

Authors:  Christian A Volk; Matthias Köck
Journal:  Org Lett       Date:  2003-10-02       Impact factor: 6.005

6.  Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products.

Authors:  Tyler A Johnson; Micaela V C Morgan; Natalie A Aratow; Samarkand A Estee; Koneni V Sashidhara; Steven T Loveridge; Nathaniel L Segraves; Phillip Crews
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050
  6 in total
  5 in total

1.  Cytotoxic Phyllactone Analogs from the Marine Sponge Phyllospongia papyrecea.

Authors:  Huawei Zhang; Phillip Crews; Karen Tenney; Frederick A Valeriote
Journal:  Med Chem       Date:  2017       Impact factor: 2.745

2.  A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge.

Authors:  Walter Balansa; Ute Mettal; Zerlina G Wuisan; Anuchit Plubrukarn; Frans G Ijong; Yang Liu; Till F Schäberle
Journal:  Mar Drugs       Date:  2019-03-08       Impact factor: 5.118

Review 3.  Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review.

Authors:  Ahmed M Elissawy; Ebrahim Soleiman Dehkordi; Negin Mehdinezhad; Mohamed L Ashour; Pardis Mohammadi Pour
Journal:  Biomolecules       Date:  2021-02-10

4.  Quantitative Analysis of Berberidis Cortex via Quantitative Analysis of Multicomponents by Single Marker (QAMS) Combined with Fingerprint and Chemometrics Methods.

Authors:  Yuting Su; Yao Peng; Jie Ren; Shangjie Wu; Si Lei; Fei Peng; Zhina Sun; Xiuqing He; Juan Li; Shunxiang Li
Journal:  J Anal Methods Chem       Date:  2022-08-25       Impact factor: 2.594

5.  Absolute Configuration Determination of Two Diastereomeric Neovasifuranones A and B from Fusarium oxysporum R1 by a Combination of Mosher's Method and Chiroptical Approach.

Authors:  Zhiyang Fu; Yuanyuan Liu; Meijie Xu; Xiaojun Yao; Hong Wang; Huawei Zhang
Journal:  J Fungi (Basel)       Date:  2021-12-31
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.