| Literature DB >> 15109664 |
Naoya Oku1, Koji Nagai, Nobuaki Shindoh, Yoh Terada, Rob W M van Soest, Shigeki Matsunaga, Nobuhiro Fusetani.
Abstract
Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E (3), were isolated together with the known cyclostellettamine A (4) from a marine sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were determined by spectral and chemical methods. They inhibit histone deacetylase derived from K562 human leukemia cells with IC(50) values ranging from 17 to 80 microM.Entities:
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Year: 2004 PMID： 15109664 DOI： 10.1016/j.bmcl.2004.02.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823