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Literature DB >> 14507174

Viscosamine: the first naturally occurring trimeric 3-alkyl pyridinium alkaloid.

Abstract

[structure: see text] Pyridinium alkaloids are widely distributed in marine sponges of different genera. Chemical investigation of the Arctic sponge Haliclona viscosa led to the isolation of a new trimeric 3-alkyl pyridinium alkaloid (viscosamine). Trimers have not been described as natural products yet. The isolation and the structure elucidation of viscosamine are discussed in detail.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2003 PMID： 14507174 DOI： 10.1021/ol035006i

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

13 in total

1. Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.

Authors: Boris Rodenko; Mohammed I Al-Salabi; Ibrahim A Teka; William Ho; Nasser El-Sabbagh; Juma A M Ali; Hasan M S Ibrahim; Martin J Wanner; Gerrit-Jan Koomen; Harry P de Koning
Journal: ACS Med Chem Lett Date: 2011-10-05 Impact factor: 4.345

2. A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp. and its cytotoxic activity.

Authors: Huawei Zhang; Steven T Loveridge; Karen Tenney; Phillip Crews
Journal: Nat Prod Res Date: 2015-07-13 Impact factor: 2.861

Review 3. Synthesis of 3-alkyl pyridinium alkaloids from the arctic sponge Haliclona viscosa.

Authors: Christoph Timm; Thorsten Mordhorst; Matthias Köck
Journal: Mar Drugs Date: 2010-03-05 Impact factor: 5.118

4. An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.

Authors: Anna R Kaplan; Cassandra L Schrank; William M Wuest
Journal: ChemMedChem Date: 2021-04-14 Impact factor: 3.540

5. Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA.

Authors: Debra McLaggan; Noppadon Adjimatera; Kristina Sepcić; Marcel Jaspars; David J MacEwan; Ian S Blagbrough; Roderick H Scott
Journal: BMC Biotechnol Date: 2006-01-16 Impact factor: 2.563

Review 10. Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.

Authors: Mohammad Ferdous Mehbub; Jie Lei; Christopher Franco; Wei Zhang
Journal: Mar Drugs Date: 2014-08-19 Impact factor: 5.118

Viscosamine: the first naturally occurring trimeric 3-alkyl pyridinium alkaloid.

1. Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.

2. A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp. and its cytotoxic activity.

Review 3. Synthesis of 3-alkyl pyridinium alkaloids from the arctic sponge Haliclona viscosa.

4. An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.

5. Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA.

6. Activity of Haliscosamine against Fusarium oxysporum f.sp. melonis: in vitro and in vivo analysis.

Review 7. Trypanocidal activity of marine natural products.

8. In vitro screening of antifungal activity of marine sponge extracts against five phytopathogenic fungi.

9. Haliscosamine: a new antifungal sphingosine derivative from the Moroccan marine sponge Haliclona viscosa.

Review 10. Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.