Francesco Bertagna1, Arnoldo Piccardo2, Bassam Dib2, Mattia Bertoli3, Federica Fracassi3, Giovanni Bosio3, Raffaele Giubbini3, Giorgio Biasiotto4, Luca Giovanella4,5, Giorgio Treglia4. 1. Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy. francesco.bertagna@spedalicivili.brescia.it. 2. Department of Nuclear Medicine, Ospedali Galliera, Genoa, Italy. 3. Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy. 4. Biomedical Technology Department, University of Brescia, Brescia, Italy. 5. Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Abstract
AIM: The purpose of our study was to establish the prevalence and pathological nature of fluorine-18-fluorodeoxyglucose (18F-FDG) prostate incidental uptake (PIU) among patients studied for non-prostate-malignant purposes in three nuclear medicine centres. METHODS: We retrospectively evaluated 20,422 scans performed on male patients; all patients underwent 18F-FDG-PET/CT for purposes not related to prostate disease. RESULTS: Among 20,422 patients PIU was identified for 280 (1.4 %) with an average age of 70 ± 10.7 years. Sixty-three of the 280 patients with PIU (22.5 %) underwent PSA dosage and biopsy to determine the nature of the incidental uptake. Thirty-five of the 63 (55.5 %) PIU were malignant whereas 28/63 (44.5 %) were benign. The average value of PSA for patients with benign PIU was 3.7 ± 2.8 ng/ml whereas it was 7.8 ± 8.2 ng/ml in patients with malignant PIU; this difference was statistically significant. For malignant lesions, the average lesion-to-liver SUVmax ratio was 2.9 ± 2.5 and the average lesion-to-blood-pool SUVmax ratio was 3.7 ± 2.5. For benign lesions, the average lesion-to-liver SUVmax ratio was 2.5 ± 1.7 and the average lesion-to-blood-pool SUVmax ratio was 3.5 ± 2.4; there was no statistically significant difference between lesion-to-liver and lesion-to-blood-pool SUVmax ratios for benign and malignant lesions. CONCLUSION: Because PIU values are indicative of malignancy for a substantial percentage of patients, further investigation is required.
AIM: The purpose of our study was to establish the prevalence and pathological nature of fluorine-18-fluorodeoxyglucose (18F-FDG) prostate incidental uptake (PIU) among patients studied for non-prostate-malignant purposes in three nuclear medicine centres. METHODS: We retrospectively evaluated 20,422 scans performed on male patients; all patients underwent 18F-FDG-PET/CT for purposes not related to prostate disease. RESULTS: Among 20,422 patients PIU was identified for 280 (1.4 %) with an average age of 70 ± 10.7 years. Sixty-three of the 280 patients with PIU (22.5 %) underwent PSA dosage and biopsy to determine the nature of the incidental uptake. Thirty-five of the 63 (55.5 %) PIU were malignant whereas 28/63 (44.5 %) were benign. The average value of PSA for patients with benign PIU was 3.7 ± 2.8 ng/ml whereas it was 7.8 ± 8.2 ng/ml in patients with malignant PIU; this difference was statistically significant. For malignant lesions, the average lesion-to-liver SUVmax ratio was 2.9 ± 2.5 and the average lesion-to-blood-pool SUVmax ratio was 3.7 ± 2.5. For benign lesions, the average lesion-to-liver SUVmax ratio was 2.5 ± 1.7 and the average lesion-to-blood-pool SUVmax ratio was 3.5 ± 2.4; there was no statistically significant difference between lesion-to-liver and lesion-to-blood-pool SUVmax ratios for benign and malignant lesions. CONCLUSION: Because PIU values are indicative of malignancy for a substantial percentage of patients, further investigation is required.
Authors: Pil Moon Kang; Won Ik Seo; Sun Seong Lee; Sang Kyun Bae; Ho Sup Kwak; Kweonsik Min; Wansuk Kim; Dong Il Kang Journal: Asian Pac J Cancer Prev Date: 2014
Authors: Alejandro Godoy; Viviana Ulloa; Federico Rodríguez; Karin Reinicke; Alejandro J Yañez; María de los Angeles García; Rodolfo A Medina; Mónica Carrasco; Sofía Barberis; Tamara Castro; Fernando Martínez; Ximena Koch; Juan Carlos Vera; María Teresa Poblete; Carlos D Figueroa; Bruno Peruzzo; Fernando Pérez; Francisco Nualart Journal: J Cell Physiol Date: 2006-06 Impact factor: 6.384