Zhongyi Yang1, Silong Hu1, Jingyi Cheng1, Junyan Xu1, Wei Shi1, Beiling Zhu1, Yongping Zhang1, Zhifeng Yao1, Herong Pan1, Yingjian Zhang2. 1. Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. 2. Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address: profzhangyj@163.com.
Abstract
OBJECTIVE: The objective was to investigate the prevalence of incidental fluorine-18 fluorodeoxyglucose (FDG) uptake in positron emission tomography/computed tomography. METHODS: A total of 11,239 male nonprostate disease patients were included retrospectively. RESULTS: The prevalence of incidental prostate FDG uptake was approximately 1.8%. Among 198 incidental lesions, 100 patients had further examinations; 20 lesions were confirmed to be malignant, while 80 lesions were benign. After logistic regression analysis, age, site, and the maximum standard uptake value were the potent predictors for differentiation of malignant prostate lesions. CONCLUSION: When focal FDG uptake in the peripheral zone of prostate is detected, especially in elderly men, further clinical evaluation is recommended.
OBJECTIVE: The objective was to investigate the prevalence of incidental fluorine-18 fluorodeoxyglucose (FDG) uptake in positron emission tomography/computed tomography. METHODS: A total of 11,239 male nonprostate disease patients were included retrospectively. RESULTS: The prevalence of incidental prostate FDG uptake was approximately 1.8%. Among 198 incidental lesions, 100 patients had further examinations; 20 lesions were confirmed to be malignant, while 80 lesions were benign. After logistic regression analysis, age, site, and the maximum standard uptake value were the potent predictors for differentiation of malignant prostate lesions. CONCLUSION: When focal FDG uptake in the peripheral zone of prostate is detected, especially in elderly men, further clinical evaluation is recommended.
Authors: Nicholas B Larson; Shannon K McDonnell; Zach Fogarty; Melissa C Larson; John Cheville; Shaun Riska; Saurabh Baheti; Alexandra M Weber; Asha A Nair; Liang Wang; Daniel O'Brien; Jaime Davila; Daniel J Schaid; Stephen N Thibodeau Journal: Oncotarget Date: 2017-09-08