| Literature DB >> 26151821 |
Fredrick R Schumacher1, Stephanie L Schmit1,2, Shuo Jiao3, Christopher K Edlund1, Hansong Wang4, Ben Zhang5, Li Hsu3, Shu-Chen Huang1, Christopher P Fischer6, John F Harju6, Gregory E Idos1, Flavio Lejbkowicz7,8, Frank J Manion6, Kevin McDonnell1, Caroline E McNeil1, Marilena Melas1, Hedy S Rennert7,8, Wei Shi9, Duncan C Thomas1, David J Van Den Berg1, Carolyn M Hutter10, Aaron K Aragaki3, Katja Butterbach11, Bette J Caan12, Christopher S Carlson3, Stephen J Chanock13, Keith R Curtis3, Charles S Fuchs14,15, Manish Gala16, Edward L Giovannucci17,18, Stephanie M Gogarten19, Richard B Hayes20, Brian Henderson1, David J Hunter21, Rebecca D Jackson22, Laurence N Kolonel23, Charles Kooperberg3, Sébastien Küry24, Andrea LaCroix3, Cathy C Laurie19, Cecelia A Laurie19, Mathieu Lemire25, David Levine19, Jing Ma26, Karen W Makar3, Conghui Qu3, Darin Taverna27, Cornelia M Ulrich3,28,29, Kana Wu30, Suminori Kono31, Dee W West32, Sonja I Berndt13, Stéphane Bezieau33, Hermann Brenner11, Peter T Campbell34, Andrew T Chan16,17, Jenny Chang-Claude35, Gerhard A Coetzee1, David V Conti1,36, David Duggan37, Jane C Figueiredo1, Barbara K Fortini1, Steven J Gallinger38, W James Gauderman1, Graham Giles39, Roger Green40, Robert Haile41, Tabitha A Harrison3, Michael Hoffmeister11, John L Hopper42, Thomas J Hudson43, Eric Jacobs34, Motoki Iwasaki44, Sun Ha Jee45, Mark Jenkins46, Wei-Hua Jia47, Amit Joshi48, Li Li49, Noralene M Lindor50, Keitaro Matsuo31, Victor Moreno51, Bhramar Mukherjee52, Polly A Newcomb53, John D Potter53, Leon Raskin1,54,55, Gad Rennert1,7,8,56, Stephanie Rosse3, Gianluca Severi39,57, Robert E Schoen58, Daniela Seminara59, Xiao-Ou Shu55,60, Martha L Slattery61, Shoichiro Tsugane44, Emily White3, Yong-Bing Xiang62, Brent W Zanke63,64, Wei Zheng54,55, Loic Le Marchand4, Graham Casey1, Stephen B Gruber1,2, Ulrike Peters3.
Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.Entities:
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Year: 2015 PMID： 26151821 PMCID： PMC4967357 DOI： 10.1038/ncomms8138
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919