Literature DB >> 32188599

Genetic Predictors of Circulating 25-Hydroxyvitamin D and Prognosis after Colorectal Cancer.

Sonja Neumeyer1,2, Katja Butterbach1,3, Barbara L Banbury4, Sonja I Berndt5, Peter T Campbell6, Rowan T Chlebowski7, Andrew T Chan8,9,10, Edward L Giovannucci9,10,11,12, Amit D Joshi10,12, Shuji Ogino12,13,14, Mingyang Song8,10,11,12, Marjorie L McCullough6, Haifa Maalmi3,15, JoAnn E Manson9,12,16, Lori C Sakoda4,17, Robert E Schoen18, Martha L Slattery19, Emily White4, Aung K Win20, Jane C Figueiredo21, John L Hopper20, Finlay A Macrae22, Ulrike Peters4,23, Hermann Brenner3,24,25, Michael Hoffmeister3, Polly A Newcomb4, Jenny Chang-Claude26,27.   

Abstract

BACKGROUND: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations in patients with colorectal cancer have been consistently associated with higher mortality in observational studies. It is unclear whether low 25(OH)D levels directly influence colorectal cancer mortality. To minimize bias, we use genetic variants associated with vitamin D levels to evaluate the association with overall and colorectal cancer-specific survival.
METHODS: Six genetic variants have been robustly identified to be associated with 25(OH)D levels in genome-wide association studies. On the basis of data from the International Survival Analysis in Colorectal Cancer Consortium, the individual genetic variants and a weighted genetic risk score were tested for association with overall and colorectal cancer-specific survival using Cox proportional hazards models in 7,657 patients with stage I to IV colorectal cancer, of whom 2,438 died from any cause and 1,648 died from colorectal cancer.
RESULTS: The 25(OH)D decreasing allele of SNP rs2282679 (GC gene, encodes group-specific component/vitamin D-binding protein) was associated with poorer colorectal cancer-specific survival, although not significant after multiple-testing correction. None of the other five SNPs showed an association. The genetic risk score showed nonsignificant associations with increased overall [HR = 1.54; confidence interval (CI), 0.86-2.78] and colorectal cancer-specific mortality (HR = 1.76; 95% CI, 0.86-3.58). A significant increased risk of overall mortality was observed in women (HR = 3.26; 95% CI, 1.45-7.33; P heterogeneity = 0.01) and normal-weight individuals (HR = 4.14; 95% CI, 1.50-11.43, P heterogeneity = 0.02).
CONCLUSIONS: Our results provided little evidence for an association of genetic predisposition of lower vitamin D levels with increased overall or colorectal cancer-specific survival, although power might have been an issue. IMPACT: Further studies are warranted to investigate the association in specific subgroups. ©2020 American Association for Cancer Research.

Entities:  

Year:  2020        PMID： 32188599      PMCID： PMC7269850          DOI： 10.1158/1055-9965.EPI-19-1409

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  53 in total

1.  The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics.

Authors:  Eugenia E Calle; Carmen Rodriguez; Eric J Jacobs; M Lyn Almon; Ann Chao; Marjorie L McCullough; Heather S Feigelson; Michael J Thun
Journal:  Cancer       Date:  2002-05-01       Impact factor: 6.860

Review 2.  The endocrine vitamin D system in the gut.

Authors:  Antonio Barbáchano; Asunción Fernández-Barral; Gemma Ferrer-Mayorga; Alba Costales-Carrera; María Jesús Larriba; Alberto Muñoz
Journal:  Mol Cell Endocrinol       Date:  2016-11-29       Impact factor: 4.102

3.  Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer.

Authors:  Kimmie Ng; Jeffrey A Meyerhardt; Kana Wu; Diane Feskanich; Bruce W Hollis; Edward L Giovannucci; Charles S Fuchs
Journal:  J Clin Oncol       Date:  2008-06-20       Impact factor: 44.544

4.  Global patterns and trends in colorectal cancer incidence and mortality.

Authors:  Melina Arnold; Mónica S Sierra; Mathieu Laversanne; Isabelle Soerjomataram; Ahmedin Jemal; Freddie Bray
Journal:  Gut       Date:  2016-01-27       Impact factor: 23.059

5.  Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis.

Authors:  Laura Perna; Katja Butterbach; Ulrike Haug; Ben Schöttker; Heiko Müller; Volker Arndt; Bernd Holleczek; Barbara Burwinkel; Hermann Brenner
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2013-01-08       Impact factor: 4.254

6.  Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:  Stephanie L Schmit; Christopher K Edlund; Fredrick R Schumacher; Jian Gong; Tabitha A Harrison; Jeroen R Huyghe; Chenxu Qu; Marilena Melas; David J Van Den Berg; Hansong Wang; Stephanie Tring; Sarah J Plummer; Demetrius Albanes; M Henar Alonso; Christopher I Amos; Kristen Anton; Aaron K Aragaki; Volker Arndt; Elizabeth L Barry; Sonja I Berndt; Stéphane Bezieau; Stephanie Bien; Amanda Bloomer; Juergen Boehm; Marie-Christine Boutron-Ruault; Hermann Brenner; Stefanie Brezina; Daniel D Buchanan; Katja Butterbach; Bette J Caan; Peter T Campbell; Christopher S Carlson; Jose E Castelao; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Iona Cheng; Ya-Wen Cheng; Lee Soo Chin; James M Church; Timothy Church; Gerhard A Coetzee; Michelle Cotterchio; Marcia Cruz Correa; Keith R Curtis; David Duggan; Douglas F Easton; Dallas English; Edith J M Feskens; Rocky Fischer; Liesel M FitzGerald; Barbara K Fortini; Lars G Fritsche; Charles S Fuchs; Manuela Gago-Dominguez; Manish Gala; Steven J Gallinger; W James Gauderman; Graham G Giles; Edward L Giovannucci; Stephanie M Gogarten; Clicerio Gonzalez-Villalpando; Elena M Gonzalez-Villalpando; William M Grady; Joel K Greenson; Andrea Gsur; Marc Gunter; Christopher A Haiman; Jochen Hampe; Sophia Harlid; John F Harju; Richard B Hayes; Philipp Hofer; Michael Hoffmeister; John L Hopper; Shu-Chen Huang; Jose Maria Huerta; Thomas J Hudson; David J Hunter; Gregory E Idos; Motoki Iwasaki; Rebecca D Jackson; Eric J Jacobs; Sun Ha Jee; Mark A Jenkins; Wei-Hua Jia; Shuo Jiao; Amit D Joshi; Laurence N Kolonel; Suminori Kono; Charles Kooperberg; Vittorio Krogh; Tilman Kuehn; Sébastien Küry; Andrea LaCroix; Cecelia A Laurie; Flavio Lejbkowicz; Mathieu Lemire; Heinz-Josef Lenz; David Levine; Christopher I Li; Li Li; Wolfgang Lieb; Yi Lin; Noralane M Lindor; Yun-Ru Liu; Fotios Loupakis; Yingchang Lu; Frank Luh; Jing Ma; Christoph Mancao; Frank J Manion; Sanford D Markowitz; Vicente Martin; Koichi Matsuda; Keitaro Matsuo; Kevin J McDonnell; Caroline E McNeil; Roger Milne; Antonio J Molina; Bhramar Mukherjee; Neil Murphy; Polly A Newcomb; Kenneth Offit; Hanane Omichessan; Domenico Palli; Jesus P Paredes Cotoré; Julyann Pérez-Mayoral; Paul D Pharoah; John D Potter; Conghui Qu; Leon Raskin; Gad Rennert; Hedy S Rennert; Bridget M Riggs; Clemens Schafmayer; Robert E Schoen; Thomas A Sellers; Daniela Seminara; Gianluca Severi; Wei Shi; David Shibata; Xiao-Ou Shu; Erin M Siegel; Martha L Slattery; Melissa Southey; Zsofia K Stadler; Mariana C Stern; Sebastian Stintzing; Darin Taverna; Stephen N Thibodeau; Duncan C Thomas; Antonia Trichopoulou; Shoichiro Tsugane; Cornelia M Ulrich; Franzel J B van Duijnhoven; Bethany van Guelpan; Joseph Vijai; Jarmo Virtamo; Stephanie J Weinstein; Emily White; Aung Ko Win; Alicja Wolk; Michael Woods; Anna H Wu; Kana Wu; Yong-Bing Xiang; Yun Yen; Brent W Zanke; Yi-Xin Zeng; Ben Zhang; Niha Zubair; Sun-Seog Kweon; Jane C Figueiredo; Wei Zheng; Loic Le Marchand; Annika Lindblom; Victor Moreno; Ulrike Peters; Graham Casey; Li Hsu; David V Conti; Stephen B Gruber
Journal:  J Natl Cancer Inst       Date:  2019-02-01       Impact factor: 13.506

7.  Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

Authors:  Thomas J Wang; Feng Zhang; J Brent Richards; Bryan Kestenbaum; Joyce B van Meurs; Diane Berry; Douglas P Kiel; Elizabeth A Streeten; Claes Ohlsson; Daniel L Koller; Leena Peltonen; Jason D Cooper; Paul F O'Reilly; Denise K Houston; Nicole L Glazer; Liesbeth Vandenput; Munro Peacock; Julia Shi; Fernando Rivadeneira; Mark I McCarthy; Pouta Anneli; Ian H de Boer; Massimo Mangino; Bernet Kato; Deborah J Smyth; Sarah L Booth; Paul F Jacques; Greg L Burke; Mark Goodarzi; Ching-Lung Cheung; Myles Wolf; Kenneth Rice; David Goltzman; Nick Hidiroglou; Martin Ladouceur; Nicholas J Wareham; Lynne J Hocking; Deborah Hart; Nigel K Arden; Cyrus Cooper; Suneil Malik; William D Fraser; Anna-Liisa Hartikainen; Guangju Zhai; Helen M Macdonald; Nita G Forouhi; Ruth J F Loos; David M Reid; Alan Hakim; Elaine Dennison; Yongmei Liu; Chris Power; Helen E Stevens; Laitinen Jaana; Ramachandran S Vasan; Nicole Soranzo; Jörg Bojunga; Bruce M Psaty; Mattias Lorentzon; Tatiana Foroud; Tamara B Harris; Albert Hofman; John-Olov Jansson; Jane A Cauley; Andre G Uitterlinden; Quince Gibson; Marjo-Riitta Järvelin; David Karasik; David S Siscovick; Michael J Econs; Stephen B Kritchevsky; Jose C Florez; John A Todd; Josee Dupuis; Elina Hyppönen; Timothy D Spector
Journal:  Lancet       Date:  2010-06-10       Impact factor: 79.321

8.  Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis.

Authors:  Y Kim; Y Je
Journal:  Br J Cancer       Date:  2014-04-08       Impact factor: 7.640

9.  Association between vitamin D supplementation and mortality: systematic review and meta-analysis.

Authors:  Yu Zhang; Fang Fang; Jingjing Tang; Lu Jia; Yuning Feng; Ping Xu; Andrew Faramand
Journal:  BMJ       Date:  2019-08-12

10.  A reference panel of 64,976 haplotypes for genotype imputation.

Authors:  Shane McCarthy; Sayantan Das; Warren Kretzschmar; Olivier Delaneau; Andrew R Wood; Alexander Teumer; Hyun Min Kang; Christian Fuchsberger; Petr Danecek; Kevin Sharp; Yang Luo; Carlo Sidore; Alan Kwong; Nicholas Timpson; Seppo Koskinen; Scott Vrieze; Laura J Scott; He Zhang; Anubha Mahajan; Jan Veldink; Ulrike Peters; Carlos Pato; Cornelia M van Duijn; Christopher E Gillies; Ilaria Gandin; Massimo Mezzavilla; Arthur Gilly; Massimiliano Cocca; Michela Traglia; Andrea Angius; Jeffrey C Barrett; Dorrett Boomsma; Kari Branham; Gerome Breen; Chad M Brummett; Fabio Busonero; Harry Campbell; Andrew Chan; Sai Chen; Emily Chew; Francis S Collins; Laura J Corbin; George Davey Smith; George Dedoussis; Marcus Dorr; Aliki-Eleni Farmaki; Luigi Ferrucci; Lukas Forer; Ross M Fraser; Stacey Gabriel; Shawn Levy; Leif Groop; Tabitha Harrison; Andrew Hattersley; Oddgeir L Holmen; Kristian Hveem; Matthias Kretzler; James C Lee; Matt McGue; Thomas Meitinger; David Melzer; Josine L Min; Karen L Mohlke; John B Vincent; Matthias Nauck; Deborah Nickerson; Aarno Palotie; Michele Pato; Nicola Pirastu; Melvin McInnis; J Brent Richards; Cinzia Sala; Veikko Salomaa; David Schlessinger; Sebastian Schoenherr; P Eline Slagboom; Kerrin Small; Timothy Spector; Dwight Stambolian; Marcus Tuke; Jaakko Tuomilehto; Leonard H Van den Berg; Wouter Van Rheenen; Uwe Volker; Cisca Wijmenga; Daniela Toniolo; Eleftheria Zeggini; Paolo Gasparini; Matthew G Sampson; James F Wilson; Timothy Frayling; Paul I W de Bakker; Morris A Swertz; Steven McCarroll; Charles Kooperberg; Annelot Dekker; David Altshuler; Cristen Willer; William Iacono; Samuli Ripatti; Nicole Soranzo; Klaudia Walter; Anand Swaroop; Francesco Cucca; Carl A Anderson; Richard M Myers; Michael Boehnke; Mark I McCarthy; Richard Durbin
Journal:  Nat Genet       Date:  2016-08-22       Impact factor: 38.330
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