Guoxi Xie1,2, Nan Zhang3, Yibin Xie2, Christopher Nguyen2, Zixin Deng2, Xiaoming Bi4, Zhanming Fan3, Xin Liu1, Debiao Li2, Zhaoyang Fan2. 1. Shenzhen Key Lab for MRI, BCMIIS, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China. 2. Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA. 3. Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, China. 4. MR R&D, Siemens Healthcare, Los Angeles, California, USA.
Abstract
BACKGROUND: To develop and assess a sequence using DANTE dark-blood preparation combined with FLASH readout (DANTE-FLASH) for rapid isotropic-resolution three-dimensional (3D) peripheral vessel wall imaging at 3 Tesla (T). METHODS: Numerical simulations were first conducted to optimize imaging parameters for maximizing the wall-lumen contrast. The sequence, implemented at 3T, was then assessed in the bilateral superficial femoral arteries of eight healthy volunteers and three patients who were undergoing non-contrast-enhanced MRA due to known peripheral artery disease. Conventional 2D dark-blood turbo spin echo (DB-TSE) was performed as a reference in all subjects. Image quality on a 5-point scale, apparent wall signal-to-noise ratio, apparent wall-lumen contrast-to-noise ratio, wall thickness, wall area and lumen area were assessed or measured in all healthy subjects. Additionally, the agreement in the depiction of wall thickening or luminal stenosis between DANTE-FLASH and DB-TSE, or MRA was assessed using a 4-point scale in the patient study. RESULTS: DANTE-FLASH allowed for a 30-cm-long coverage within 4 min, whereas DB-TSE took approximately 7 min for a 9-cm-long coverage. Good image quality was obtained by DANTE-FLASH (score > 3). The wall thickness, wall area, and lumen area were all comparable (t-test; P = 0.334, 0.224 and 0.136) and showed excellent agreement between DANTE-FLASH and DB-TSE (intra-class correlation = 0.81, 0.85, and 0.98). The atherosclerotic plaques and luminal stenosis identified by DANTE-FLASH were in accordance with the findings by 2D DB-TSE or MRA. CONCLUSION: DANTE-FLASH is a 3D dark-blood MR sequence allowing for rapid isotropic-resolution imaging of the peripheral vessel wall at 3T.
BACKGROUND: To develop and assess a sequence using DANTE dark-blood preparation combined with FLASH readout (DANTE-FLASH) for rapid isotropic-resolution three-dimensional (3D) peripheral vessel wall imaging at 3 Tesla (T). METHODS: Numerical simulations were first conducted to optimize imaging parameters for maximizing the wall-lumen contrast. The sequence, implemented at 3T, was then assessed in the bilateral superficial femoral arteries of eight healthy volunteers and three patients who were undergoing non-contrast-enhanced MRA due to known peripheral artery disease. Conventional 2D dark-blood turbo spin echo (DB-TSE) was performed as a reference in all subjects. Image quality on a 5-point scale, apparent wall signal-to-noise ratio, apparent wall-lumen contrast-to-noise ratio, wall thickness, wall area and lumen area were assessed or measured in all healthy subjects. Additionally, the agreement in the depiction of wall thickening or luminal stenosis between DANTE-FLASH and DB-TSE, or MRA was assessed using a 4-point scale in the patient study. RESULTS: DANTE-FLASH allowed for a 30-cm-long coverage within 4 min, whereas DB-TSE took approximately 7 min for a 9-cm-long coverage. Good image quality was obtained by DANTE-FLASH (score > 3). The wall thickness, wall area, and lumen area were all comparable (t-test; P = 0.334, 0.224 and 0.136) and showed excellent agreement between DANTE-FLASH and DB-TSE (intra-class correlation = 0.81, 0.85, and 0.98). The atherosclerotic plaques and luminal stenosis identified by DANTE-FLASH were in accordance with the findings by 2D DB-TSE or MRA. CONCLUSION: DANTE-FLASH is a 3D dark-blood MR sequence allowing for rapid isotropic-resolution imaging of the peripheral vessel wall at 3T.
Authors: Alan T Hirsch; Matthew A Allison; Antoinette S Gomes; Matthew A Corriere; Sue Duval; Abby G Ershow; William R Hiatt; Richard H Karas; Marge B Lovell; Mary M McDermott; Donna M Mendes; Nancy A Nussmeier; Diane Treat-Jacobson Journal: Circulation Date: 2012-02-15 Impact factor: 29.690
Authors: Bernard Chiu; Jie Sun; Xihai Zhao; Jinnan Wang; Niranjan Balu; Jiachang Chi; Jianrong Xu; Chun Yuan; William S Kerwin Journal: Med Phys Date: 2011-10 Impact factor: 4.071
Authors: Yoshiki Matsuo; Takuro Takumi; Verghese Mathew; Woo-Young Chung; Gregory W Barsness; Charanjit S Rihal; Rajiv Gulati; Eric T McCue; David R Holmes; Eric Eeckhout; Ryan J Lennon; Lilach O Lerman; Amir Lerman Journal: Atherosclerosis Date: 2012-05-31 Impact factor: 5.162
Authors: Greg J Stanisz; Ewa E Odrobina; Joseph Pun; Michael Escaravage; Simon J Graham; Michael J Bronskill; R Mark Henkelman Journal: Magn Reson Med Date: 2005-09 Impact factor: 4.668
Authors: Michel M Joosten; Jennifer K Pai; Monica L Bertoia; Eric B Rimm; Donna Spiegelman; Murray A Mittleman; Kenneth J Mukamal Journal: JAMA Date: 2012-10-24 Impact factor: 56.272
Authors: Michael J Beck; Dennis L Parker; Bradley D Bolster; Seong-Eun Kim; J Scott McNally; Gerald S Treiman; J Rock Hadley Journal: Magn Reson Med Date: 2017-02-10 Impact factor: 4.668