| Literature DB >> 26048040 |
Lisa D Wiggins1, Susan E Levy2,3, Julie Daniels4, Laura Schieve5, Lisa A Croen6, Carolyn DiGuiseppi7, Lisa Blaskey2, Ellen Giarelli2,8, Li-Ching Lee9, Jennifer Pinto-Martin10, Ann Reynolds11, Catherine Rice5,12, Cordelia Robinson Rosenberg11, Patrick Thompson13, Marshalyn Yeargin-Allsopp5, Lisa Young10, Diana Schendel5,14,15,16.
Abstract
This study examined the phenotypic profiles of children aged 30-68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses.Entities:
Keywords: Autism; Etiology; Phenotype; Study to Explore Early Development; Symptoms
Mesh：
Year: 2015 PMID： 26048040 PMCID： PMC4573234 DOI： 10.1007/s10803-015-2476-8
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257