| Literature DB >> 32975665 |
Md Ashiquir Rahaman1, Maksuda Lopa1, K M Furkan Uddin1,2,3, Md Abdul Baqui1, Selina Parvin Keya1, Md Omar Faruk1, Shaoli Sarker1,2,4, Mohammed Basiruzzaman1,2, Mazharul Islam1,2, Ammar AlBanna5,6, Nargis Jahan1, M A K Azad Chowdhury7, Narayan Saha8, Manzoor Hussain9, Costanza Colombi9, Darren O'Rielly10, Marc Woodbury-Smith11,12, Mohammad Ghaziuddin13, Mohammad Mizanur Rahman14, Mohammed Uddin15,16.
Abstract
This study explored the physical and clinical phenotype of Bangladeshi children with autism spectrum disorder (ASD). A totally of 283 children who were referred for screening and administered Module 1 of the Autism Diagnostic Observation Schedule (ADOS) were included. Overall, 209 met the ADOS algorithmic cutoff for ASD. A trend for greater weight and head circumference was observed in children with ASD versus non-ASD. Head circumference was significantly (p < 0.03) larger in ASD males compared with non-ASD males. A trend was also observed for symptom severity, higher in females than males (p = 0.068), with further analyses demonstrating that social reciprocity (p < 0.014) and functional play (p < 0.03) were significantly more impaired in ASD females than males. The findings help understand sex differences in ASD.Entities:
Keywords: ADOS-2; Autism spectrum disorder; Head circumference; Phenotype
Mesh：
Year: 2021 PMID： 32975665 DOI： 10.1007/s10803-020-04703-0
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257