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Literature DB >> 26046759

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency.

Lorenz Studer¹, Elsa Vera², Daniela Cornacchia².

Abstract

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for studying cell-fate identity and modeling human disease. However, the reversal of cellular age during reprogramming results in an embryonic-like state of induced pluripotent stem cells (iPSCs) and their derivatives, which presents specific challenges for modeling late onset disease. This age reset requires novel methods to mimic age-related changes but also offers opportunities for studying cellular rejuvenation in real time. Here, we discuss how iPSC research may transform studies of aging and enable the precise programming of cellular age in parallel to cell-fate specification.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 26046759 PMCID： PMC4508309 DOI： 10.1016/j.stem.2015.05.004

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

89 in total

1. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

Authors: Toshinobu Nishimura; Shin Kaneko; Ai Kawana-Tachikawa; Yoko Tajima; Haruo Goto; Dayong Zhu; Kaori Nakayama-Hosoya; Shoichi Iriguchi; Yasushi Uemura; Takafumi Shimizu; Naoya Takayama; Daisuke Yamada; Ken Nishimura; Manami Ohtaka; Nobukazu Watanabe; Satoshi Takahashi; Aikichi Iwamoto; Haruhiko Koseki; Mahito Nakanishi; Koji Eto; Hiromitsu Nakauchi
Journal: Cell Stem Cell Date: 2013-01-03 Impact factor: 24.633

2. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.

Authors: Manisha Sinha; Young C Jang; Juhyun Oh; Danika Khong; Elizabeth Y Wu; Rohan Manohar; Christine Miller; Samuel G Regalado; Francesco S Loffredo; James R Pancoast; Michael F Hirshman; Jessica Lebowitz; Jennifer L Shadrach; Massimiliano Cerletti; Mi-Jeong Kim; Thomas Serwold; Laurie J Goodyear; Bernard Rosner; Richard T Lee; Amy J Wagers
Journal: Science Date: 2014-05-05 Impact factor: 47.728

3. Modern Biological Theories of Aging.

Authors: Kunlin Jin
Journal: Aging Dis Date: 2010-10-01 Impact factor: 6.745

Review 4. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity.

Authors: Michael J Conboy; Irina M Conboy; Thomas A Rando
Journal: Aging Cell Date: 2013-04-10 Impact factor: 9.304

5. Telomerase reverse transcriptase delays aging in cancer-resistant mice.

Authors: Antonia Tomás-Loba; Ignacio Flores; Pablo J Fernández-Marcos; María L Cayuela; Antonio Maraver; Agueda Tejera; Consuelo Borrás; Ander Matheu; Peter Klatt; Juana M Flores; José Viña; Manuel Serrano; Maria A Blasco
Journal: Cell Date: 2008-11-14 Impact factor: 41.582

6. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.

Authors: Francesco S Loffredo; Matthew L Steinhauser; Steven M Jay; Joseph Gannon; James R Pancoast; Pratyusha Yalamanchi; Manisha Sinha; Claudia Dall'Osso; Danika Khong; Jennifer L Shadrach; Christine M Miller; Britta S Singer; Alex Stewart; Nikolaos Psychogios; Robert E Gerszten; Adam J Hartigan; Mi-Jeong Kim; Thomas Serwold; Amy J Wagers; Richard T Lee
Journal: Cell Date: 2013-05-09 Impact factor: 41.582

7. Short-term calorie restriction enhances skeletal muscle stem cell function.

Authors: Massimiliano Cerletti; Young C Jang; Lydia W S Finley; Marcia C Haigis; Amy J Wagers
Journal: Cell Stem Cell Date: 2012-05-04 Impact factor: 24.633

8. Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

Authors: Alessandro Prigione; Amir M Hossini; Björn Lichtner; Akdes Serin; Beatrix Fauler; Matthias Megges; Rudi Lurz; Hans Lehrach; Eugenia Makrantonaki; Christos C Zouboulis; James Adjaye
Journal: PLoS One Date: 2011-11-14 Impact factor: 3.240

9. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

Authors: Luis F Z Batista; Matthew F Pech; Franklin L Zhong; Ha Nam Nguyen; Kathleen T Xie; Arthur J Zaug; Sharon M Crary; Jinkuk Choi; Vittorio Sebastiano; Athena Cherry; Neelam Giri; Marius Wernig; Blanche P Alter; Thomas R Cech; Sharon A Savage; Renee A Reijo Pera; Steven E Artandi
Journal: Nature Date: 2011-05-22 Impact factor: 49.962

10. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Authors: Gabsang Lee; Eirini P Papapetrou; Hyesoo Kim; Stuart M Chambers; Mark J Tomishima; Christopher A Fasano; Yosif M Ganat; Jayanthi Menon; Fumiko Shimizu; Agnes Viale; Viviane Tabar; Michel Sadelain; Lorenz Studer
Journal: Nature Date: 2009-08-19 Impact factor: 49.962

71 in total

Review 1. Direct somatic lineage conversion.

Authors: Koji Tanabe; Daniel Haag; Marius Wernig
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2015-10-19 Impact factor: 6.237

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency.

1. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

2. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.

3. Modern Biological Theories of Aging.

Review 4. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity.

5. Telomerase reverse transcriptase delays aging in cancer-resistant mice.

6. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.

7. Short-term calorie restriction enhances skeletal muscle stem cell function.

8. Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

9. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

10. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Review 1. Direct somatic lineage conversion.

Review 2. Understanding Parkinson's Disease through the Use of Cell Reprogramming.

Review 3. Brain organoids: advances, applications and challenges.

Review 4. Neural Subtype Specification from Human Pluripotent Stem Cells.

Review 5. Induced Pluripotent Stem Cells Meet Genome Editing.

Review 6. Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids.

Review 7. Induced pluripotent stem cell technology: a decade of progress.

Review 8. When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron.

Review 9. Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes.

Review 10. Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.