Literature DB >> 32068088

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron.

Johannes C M Schlachetzki1, Tomohisa Toda2, Jerome Mertens3.   

Abstract

The human brain is affected by cellular aging. Neurons are primarily generated during embryogenesis and early life with a limited capacity for renewal and replacement, making them some of the oldest cells in the human body. Our present understanding of neurodegenerative diseases points towards advanced neuronal age as a prerequisite for the development of these disorders. While significant progress has been made in understanding the relationship between aging and neurological disease, it will be essential to delve further into the molecular mechanisms of neuronal aging in order to develop therapeutic interventions targeting age-related brain dysfunction. In this mini review, we highlight recent findings on the relationship between the aging of nuclear structures and changes in the epigenetic landscape during neuronal aging and disease.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32068088      PMCID： PMC7086016          DOI： 10.1016/j.exger.2020.110876

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  115 in total

1.  Role of the nuclear lamina in genome organization and gene expression.

Authors:  D Peric-Hupkes; B van Steensel
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2011-01-05

2.  Identification of long-lived proteins reveals exceptional stability of essential cellular structures.

Authors:  Brandon H Toyama; Jeffrey N Savas; Sung Kyu Park; Michael S Harris; Nicholas T Ingolia; John R Yates; Martin W Hetzer
Journal:  Cell       Date:  2013-08-29       Impact factor: 41.582

3.  Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

Authors:  Erez Lieberman-Aiden; Nynke L van Berkum; Louise Williams; Maxim Imakaev; Tobias Ragoczy; Agnes Telling; Ido Amit; Bryan R Lajoie; Peter J Sabo; Michael O Dorschner; Richard Sandstrom; Bradley Bernstein; M A Bender; Mark Groudine; Andreas Gnirke; John Stamatoyannopoulos; Leonid A Mirny; Eric S Lander; Job Dekker
Journal:  Science       Date:  2009-10-09       Impact factor: 47.728

4.  Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8.

Authors:  Chun Mei Wang; Sau Na Tsai; Tai Wai Yew; Yiu Wa Kwan; Sai Ming Ngai
Journal:  Biogerontology       Date:  2009-05-12       Impact factor: 4.277

5.  Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning.

Authors:  Morgan E Levine; Ake T Lu; David A Bennett; Steve Horvath
Journal:  Aging (Albany NY)       Date:  2015-12       Impact factor: 5.682

Review 6.  Nuclear pore complexes as hubs for gene regulation.

Authors:  Maximiliano A D'Angelo
Journal:  Nucleus       Date:  2018-01-01       Impact factor: 4.197

7.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Authors:  J C Lambert; C A Ibrahim-Verbaas; D Harold; A C Naj; R Sims; C Bellenguez; A L DeStafano; J C Bis; G W Beecham; B Grenier-Boley; G Russo; T A Thorton-Wells; N Jones; A V Smith; V Chouraki; C Thomas; M A Ikram; D Zelenika; B N Vardarajan; Y Kamatani; C F Lin; A Gerrish; H Schmidt; B Kunkle; M L Dunstan; A Ruiz; M T Bihoreau; S H Choi; C Reitz; F Pasquier; C Cruchaga; D Craig; N Amin; C Berr; O L Lopez; P L De Jager; V Deramecourt; J A Johnston; D Evans; S Lovestone; L Letenneur; F J Morón; D C Rubinsztein; G Eiriksdottir; K Sleegers; A M Goate; N Fiévet; M W Huentelman; M Gill; K Brown; M I Kamboh; L Keller; P Barberger-Gateau; B McGuiness; E B Larson; R Green; A J Myers; C Dufouil; S Todd; D Wallon; S Love; E Rogaeva; J Gallacher; P St George-Hyslop; J Clarimon; A Lleo; A Bayer; D W Tsuang; L Yu; M Tsolaki; P Bossù; G Spalletta; P Proitsi; J Collinge; S Sorbi; F Sanchez-Garcia; N C Fox; J Hardy; M C Deniz Naranjo; P Bosco; R Clarke; C Brayne; D Galimberti; M Mancuso; F Matthews; S Moebus; P Mecocci; M Del Zompo; W Maier; H Hampel; A Pilotto; M Bullido; F Panza; P Caffarra; B Nacmias; J R Gilbert; M Mayhaus; L Lannefelt; H Hakonarson; S Pichler; M M Carrasquillo; M Ingelsson; D Beekly; V Alvarez; F Zou; O Valladares; S G Younkin; E Coto; K L Hamilton-Nelson; W Gu; C Razquin; P Pastor; I Mateo; M J Owen; K M Faber; P V Jonsson; O Combarros; M C O'Donovan; L B Cantwell; H Soininen; D Blacker; S Mead; T H Mosley; D A Bennett; T B Harris; L Fratiglioni; C Holmes; R F de Bruijn; P Passmore; T J Montine; K Bettens; J I Rotter; A Brice; K Morgan; T M Foroud; W A Kukull; D Hannequin; J F Powell; M A Nalls; K Ritchie; K L Lunetta; J S Kauwe; E Boerwinkle; M Riemenschneider; M Boada; M Hiltuenen; E R Martin; R Schmidt; D Rujescu; L S Wang; J F Dartigues; R Mayeux; C Tzourio; A Hofman; M M Nöthen; C Graff; B M Psaty; L Jones; J L Haines; P A Holmans; M Lathrop; M A Pericak-Vance; L J Launer; L A Farrer; C M van Duijn; C Van Broeckhoven; V Moskvina; S Seshadri; J Williams; G D Schellenberg; P Amouyel
Journal:  Nat Genet       Date:  2013-10-27       Impact factor: 38.330

Review 8.  Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

Authors:  Andrew E Teschendorff; James West; Stephan Beck
Journal:  Hum Mol Genet       Date:  2013-08-04       Impact factor: 6.150

9.  Tau promotes neurodegeneration through global chromatin relaxation.

Authors:  Bess Frost; Martin Hemberg; Jada Lewis; Mel B Feany
Journal:  Nat Neurosci       Date:  2014-01-26       Impact factor: 24.884

10.  Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies.

Authors:  Wenyan Sun; Hanie Samimi; Maria Gamez; Habil Zare; Bess Frost
Journal:  Nat Neurosci       Date:  2018-07-23       Impact factor: 24.884
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  3 in total

Review 1.  Cellular Senescence in Brain Aging.

Authors:  Ewa Sikora; Anna Bielak-Zmijewska; Magdalena Dudkowska; Adam Krzystyniak; Grazyna Mosieniak; Malgorzata Wesierska; Jakub Wlodarczyk
Journal:  Front Aging Neurosci       Date:  2021-02-25       Impact factor: 5.750

Review 2.  Accelerated neuronal aging in vitro ∼melting watch ∼.

Authors:  Emi Inagaki; Sho Yoshimatsu; Hideyuki Okano
Journal:  Front Aging Neurosci       Date:  2022-08-09       Impact factor: 5.702

Review 3.  Metabolism navigates neural cell fate in development, aging and neurodegeneration.

Authors:  Larissa Traxler; Jessica Lagerwall; Sophie Eichhorner; Davide Stefanoni; Angelo D'Alessandro; Jerome Mertens
Journal:  Dis Model Mech       Date:  2021-08-04       Impact factor: 5.758
  3 in total

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