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Literature DB >> 26040603

Applications of the CRISPR-Cas9 system in cancer biology.

Francisco J Sánchez-Rivera¹, Tyler Jacks².

Abstract

The prokaryotic type II CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) system is rapidly revolutionizing the field of genetic engineering, allowing researchers to alter the genomes of a large range of organisms with relative ease. Experimental approaches based on this versatile technology have the potential to transform the field of cancer genetics. Here, we review current approaches for functional studies of cancer genes that are based on CRISPR-Cas, with emphasis on their applicability for the development of next-generation models of human cancer.

Entities: Chemical

Mesh：

Substances：
Endonucleases

Year: 2015 PMID： 26040603 PMCID： PMC4530801 DOI： 10.1038/nrc3950

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

86 in total

1. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.

Authors: E L Jackson; N Willis; K Mercer; R T Bronson; D Crowley; R Montoya; T Jacks; D A Tuveson
Journal: Genes Dev Date: 2001-12-15 Impact factor: 11.361

2. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Authors: Marc R Mansour; Brian J Abraham; Lars Anders; Alla Berezovskaya; Alejandro Gutierrez; Adam D Durbin; Julia Etchin; Lee Lawton; Stephen E Sallan; Lewis B Silverman; Mignon L Loh; Stephen P Hunger; Takaomi Sanda; Richard A Young; A Thomas Look
Journal: Science Date: 2014-11-13 Impact factor: 47.728

3. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.

Authors: Zhao Chen; Katherine Cheng; Zandra Walton; Yuchuan Wang; Hiromichi Ebi; Takeshi Shimamura; Yan Liu; Tanya Tupper; Jing Ouyang; Jie Li; Peng Gao; Michele S Woo; Chunxiao Xu; Masahiko Yanagita; Abigail Altabef; Shumei Wang; Charles Lee; Yuji Nakada; Christopher G Peña; Yanping Sun; Yoko Franchetti; Catherine Yao; Amy Saur; Michael D Cameron; Mizuki Nishino; D Neil Hayes; Matthew D Wilkerson; Patrick J Roberts; Carrie B Lee; Nabeel Bardeesy; Mohit Butaney; Lucian R Chirieac; Daniel B Costa; David Jackman; Norman E Sharpless; Diego H Castrillon; George D Demetri; Pasi A Jänne; Pier Paolo Pandolfi; Lewis C Cantley; Andrew L Kung; Jeffrey A Engelman; Kwok-Kin Wong
Journal: Nature Date: 2012-03-18 Impact factor: 49.962

4. The differential effects of mutant p53 alleles on advanced murine lung cancer.

Authors: Erica L Jackson; Kenneth P Olive; David A Tuveson; Roderick Bronson; Denise Crowley; Michael Brown; Tyler Jacks
Journal: Cancer Res Date: 2005-11-15 Impact factor: 12.701

5. Highly efficient endogenous human gene correction using designed zinc-finger nucleases.

Authors: Fyodor D Urnov; Jeffrey C Miller; Ya-Li Lee; Christian M Beausejour; Jeremy M Rock; Sheldon Augustus; Andrew C Jamieson; Matthew H Porteus; Philip D Gregory; Michael C Holmes
Journal: Nature Date: 2005-04-03 Impact factor: 49.962

6. Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus.

Authors: A Plessis; A Perrin; J E Haber; B Dujon
Journal: Genetics Date: 1992-03 Impact factor: 4.562

7. Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system.

Authors: R Torres; M C Martin; A Garcia; Juan C Cigudosa; J C Ramirez; S Rodriguez-Perales
Journal: Nat Commun Date: 2014-06-03 Impact factor: 14.919

8. Life in the fast lane: mammalian disease models in the genomics era.

Authors: Lukas E Dow; Scott W Lowe
Journal: Cell Date: 2012-03-16 Impact factor: 41.582

9. Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

Authors: Patrick Essletzbichler; Tomasz Konopka; Federica Santoro; Doris Chen; Bianca V Gapp; Robert Kralovics; Thijn R Brummelkamp; Sebastian M B Nijman; Tilmann Bürckstümmer
Journal: Genome Res Date: 2014-11-04 Impact factor: 9.043

10. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

Authors: Pablo Perez-Pinera; D Dewran Kocak; Christopher M Vockley; Andrew F Adler; Ami M Kabadi; Lauren R Polstein; Pratiksha I Thakore; Katherine A Glass; David G Ousterout; Kam W Leong; Farshid Guilak; Gregory E Crawford; Timothy E Reddy; Charles A Gersbach
Journal: Nat Methods Date: 2013-07-25 Impact factor: 28.547

143 in total

Applications of the CRISPR-Cas9 system in cancer biology.

1. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.

2. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

3. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.

4. The differential effects of mutant p53 alleles on advanced murine lung cancer.

5. Highly efficient endogenous human gene correction using designed zinc-finger nucleases.

6. Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus.

7. Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system.

8. Life in the fast lane: mammalian disease models in the genomics era.

9. Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

10. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

1. The CRISPR road: from bench to bedside on an RNA-guided path.

Review 2. Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery.

Review 3. CRISPR applications in ophthalmologic genome surgery.

4. Breast Cancer Metastasis.

Review 5. Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities.

6. CD8⁺ T Cells and NK Cells: Parallel and Complementary Soldiers of Immunotherapy.

Review 7. Alternative splicing and cancer metastasis: prognostic and therapeutic applications.

8. The search for precision models clinically relevant to human liver cancer.

Review 9. CRISPR-Cas9: A multifaceted therapeutic strategy for cancer treatment.

10. CRISPR Technology for Breast Cancer: Diagnostics, Modeling, and Therapy.