Literature DB >> 26036700

Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease.

Rameshwar Patil1, Pallavi R Gangalum1, Shawn Wagner2, Jose Portilla-Arias1, Hui Ding1, Arthur Rekechenetskiy1, Bindu Konda1, Satoshi Inoue1, Keith L Black1, Julia Y Ljubimova1, Eggehard Holler3.   

Abstract

Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to Aβ plaques which is a hallmark of AD. To address this binding, we have designed a novel nanoimaging agent (NIA) based on nature-derived poly(β-l-malic acid) (PMLA) containing covalently attached gadolinium-DOTA(Gd-DOTA) and nature-derived CUR. The all-in-one agent recognizes and selectively binds to Aβ plaques and is detected by MRI. It efficiently detected Aβ plaques in human and mouse samples by an ex vivo staining. The method can be useful in clinic for safe and noninvasive diagnosis of AD.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Alzheimer disease; curcumin; MRI; nanoimaging agent; polymalic acid

Mesh：

Substances：

Year:  2015        PMID： 26036700      PMCID： PMC4794283          DOI： 10.1002/mabi.201500062

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  21 in total

1.  Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].

Authors:  Hui Ding; Satoshi Inoue; Alexander V Ljubimov; Rameshwar Patil; Jose Portilla-Arias; Jinwei Hu; Bindu Konda; Kolja A Wawrowsky; Manabu Fujita; Natalya Karabalin; Takako Sasaki; Keith L Black; Eggehard Holler; Julia Y Ljubimova
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-04       Impact factor: 11.205

Review 2.  Alzheimer's disease: genes, proteins, and therapy.

Authors:  D J Selkoe
Journal:  Physiol Rev       Date:  2001-04       Impact factor: 37.312

Review 3.  Clinical features of Alzheimer's disease.

Authors:  H Förstl; A Kurz
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1999       Impact factor: 5.270

4.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

Authors:  G G Glenner; C W Wong
Journal:  Biochem Biophys Res Commun       Date:  1984-05-16       Impact factor: 3.575

Review 5.  The molecular bases of Alzheimer's disease and other neurodegenerative disorders.

Authors:  R B Maccioni; J P Muñoz; L Barbeito
Journal:  Arch Med Res       Date:  2001 Sep-Oct       Impact factor: 2.235

6.  Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.

Authors:  William E Klunk; Henry Engler; Agneta Nordberg; Yanming Wang; Gunnar Blomqvist; Daniel P Holt; Mats Bergström; Irina Savitcheva; Guo-feng Huang; Sergio Estrada; Birgitta Ausén; Manik L Debnath; Julien Barletta; Julie C Price; Johan Sandell; Brian J Lopresti; Anders Wall; Pernilla Koivisto; Gunnar Antoni; Chester A Mathis; Bengt Långström
Journal:  Ann Neurol       Date:  2004-03       Impact factor: 10.422

7.  Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Authors:  C L Masters; G Simms; N A Weinman; G Multhaup; B L McDonald; K Beyreuther
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

8.  Factors affecting course and survival in Alzheimer's disease. A 9-year longitudinal study.

Authors:  L Bracco; R Gallato; F Grigoletto; A Lippi; V Lepore; G Bino; M P Lazzaro; F Carella; T Piccolo; C Pozzilli
Journal:  Arch Neurol       Date:  1994-12

9.  Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment.

Authors:  Jose Portilla-Arias; Rameshwar Patil; Hui Ding; Julia Y Ljubimova; Satoshi Inoue; Janet L Markman; Arthur Rekechenetskiy; Bindu Konda; Pallavi R Gangalum; Alexandra Chesnokova; Alexander V Ljubimov; Keith L Black; Eggehard Holler
Journal:  J Drug Target       Date:  2013-09-16       Impact factor: 5.121

10.  Synthesis, degradability, and drug releasing properties of methyl esters of fungal poly(beta,L-malic acid).

Authors:  José A Portilla-Arias; Montserrat García-Alvarez; Antxon Martínez de Ilarduya; Eggerhard Holler; Juan A Galbis; Sebastián Muñoz-Guerra
Journal:  Macromol Biosci       Date:  2008-06-11       Impact factor: 4.979
View more
  9 in total

Review 1.  Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain.

Authors:  Kaihua Chen; Mengchao Cui
Journal:  Medchemcomm       Date:  2017-05-16       Impact factor: 3.597

2.  Nanoscale Coordination Polymers Codeliver Chemotherapeutics and siRNAs to Eradicate Tumors of Cisplatin-Resistant Ovarian Cancer.

Authors:  Chunbai He; Christopher Poon; Christina Chan; S Diane Yamada; Wenbin Lin
Journal:  J Am Chem Soc       Date:  2016-05-02       Impact factor: 15.419

Review 3.  A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging.

Authors:  Yì Xiáng J Wáng; Jean-Marc Idée
Journal:  Quant Imaging Med Surg       Date:  2017-02

4.  Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process.

Authors:  Rohmad Yudi Utomo; Satoshi Okada; Akira Sumiyoshi; Ichio Aoki; Hiroyuki Nakamura
Journal:  RSC Adv       Date:  2022-02-09       Impact factor: 3.361

Review 5.  Polymalic acid for translational nanomedicine.

Authors:  Xing Huang; Liusheng Xu; Hui Qian; Xinghuan Wang; Zhimin Tao
Journal:  J Nanobiotechnology       Date:  2022-06-21       Impact factor: 9.429

6.  Wearable Natural Rubber Latex Gloves with Curcumin for Torn Glove Detection in Clinical Settings.

Authors:  Norfatirah Muhamad Sarih; Nuur Syuhada Dzulkafly; Simon Maher; Azura A Rashid
Journal:  Polymers (Basel)       Date:  2022-07-28       Impact factor: 4.967

7.  Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid production from sugarcane molasses.

Authors:  Jun Feng; Jing Yang; Wenwen Yang; Jie Chen; Min Jiang; Xiang Zou
Journal:  Biotechnol Biofuels       Date:  2018-04-04       Impact factor: 6.040

Review 8.  Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease.

Authors:  Min Chen; Zhi-Yun Du; Xi Zheng; Dong-Li Li; Ren-Ping Zhou; Kun Zhang
Journal:  Neural Regen Res       Date:  2018-04       Impact factor: 5.135

9.  Curcumin incorporated titanium dioxide nanoparticles as MRI contrasting agent for early diagnosis of atherosclerosis- rat model.

Authors:  Sainulabdeen Sherin; Sreedharan Balachandran; Annie Abraham
Journal:  Vet Anim Sci       Date:  2020-05-12
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.