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Literature DB >> 30108850

Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain.

Abstract

In this review, we have focused on the recent progress in metal complexes that are able to bind to β-amyloid (Aβ) species. We have discussed various radioactive complexes of 99mTc, 68Ga, 64Cu, 89Zr, and 111In, which were designed as Aβ imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, non-radioactive Re and Ru complexes as Aβ sensors using luminescence methods, and Gd3+ complexes as contrast agents for magnetic resonance imaging (MRI).

Entities: Chemical Gene

Year: 2017 PMID： 30108850 PMCID： PMC6072098 DOI： 10.1039/c7md00064b

Source DB: PubMed Journal: Medchemcomm ISSN： 2040-2503 Impact factor: 3.597

100 in total

1. 99mTc-Labeled Small Peptides as Diagnostic Radiopharmaceuticals.

Authors: S Liu; D S Edwards
Journal: Chem Rev Date: 1999-09-08 Impact factor: 60.622

2. Synthesis and evaluation of novel chalcone derivatives with (99m)Tc/Re complexes as potential probes for detection of β-amyloid plaques.

Authors: Masahiro Ono; Ryoichi Ikeoka; Hiroyuki Watanabe; Hiroyuki Kimura; Takeshi Fuchigami; Mamoru Haratake; Hideo Saji; Morio Nakayama
Journal: ACS Chem Neurosci Date: 2010-07-08 Impact factor: 4.418

3. 99mTc(CO)3-Labeled Benzothiazole Derivatives Preferentially Bind Cerebrovascular Amyloid: Potential Use as Imaging Agents for Cerebral Amyloid Angiopathy.

Authors: Jianhua Jia; Mengchao Cui; Jiapei Dai; Boli Liu
Journal: Mol Pharm Date: 2015-06-25 Impact factor: 4.939

4. Synthesis and characterization of (68)Ga-labeled curcumin and curcuminoid complexes as potential radiotracers for imaging of cancer and Alzheimer's disease.

Authors: Mattia Asti; Erika Ferrari; Stefania Croci; Giulia Atti; Sara Rubagotti; Michele Iori; Pier C Capponi; Alessandro Zerbini; Monica Saladini; Annibale Versari
Journal: Inorg Chem Date: 2014-04-25 Impact factor: 5.165

5. Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine.

Authors: Maria J W D Vosjan; Lars R Perk; Gerard W M Visser; Marianne Budde; Paul Jurek; Garry E Kiefer; Guus A M S van Dongen
Journal: Nat Protoc Date: 2010-03-25 Impact factor: 13.491

6. Curcumin as the OO bidentate ligand in "2 + 1" complexes with the [M(CO)3]+ (M = Re, 99mTc) tricarbonyl core for radiodiagnostic applications.

Authors: Marina Sagnou; Dimitra Benaki; Charalampos Triantis; Theodoros Tsotakos; Vassilis Psycharis; Catherine P Raptopoulou; Ioannis Pirmettis; Minas Papadopoulos; Maria Pelecanou
Journal: Inorg Chem Date: 2011-01-21 Impact factor: 5.165

7. Sensing and inhibition of amyloid-β based on the simple luminescent aptamer-ruthenium complex system.

Authors: Eththilu Babu; Paulpandian Muthu Mareeswaran; Veerasamy Sathish; Subramanian Singaravadivel; Seenivasan Rajagopal
Journal: Talanta Date: 2014-11-15 Impact factor: 6.057

8. Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes.

Authors: Willa D Brenowitz; Peter T Nelson; Lilah M Besser; Katherine B Heller; Walter A Kukull
Journal: Neurobiol Aging Date: 2015-07-08 Impact factor: 4.673

9. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

Authors: Chester A Mathis; Yanming Wang; Daniel P Holt; Guo-Feng Huang; Manik L Debnath; William E Klunk
Journal: J Med Chem Date: 2003-06-19 Impact factor: 7.446

10. Novel Bivalent 99mTc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy.

Authors: Shimpei Iikuni; Masahiro Ono; Hiroyuki Watanabe; Masashi Yoshimura; Hatsue Ishibashi-Ueda; Masafumi Ihara; Hideo Saji
Journal: PLoS One Date: 2016-09-30 Impact factor: 3.240

5 in total

Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain.

1. 99mTc-Labeled Small Peptides as Diagnostic Radiopharmaceuticals.

2. Synthesis and evaluation of novel chalcone derivatives with (99m)Tc/Re complexes as potential probes for detection of β-amyloid plaques.

3. 99mTc(CO)3-Labeled Benzothiazole Derivatives Preferentially Bind Cerebrovascular Amyloid: Potential Use as Imaging Agents for Cerebral Amyloid Angiopathy.

4. Synthesis and characterization of (68)Ga-labeled curcumin and curcuminoid complexes as potential radiotracers for imaging of cancer and Alzheimer's disease.

5. Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine.

6. Curcumin as the OO bidentate ligand in "2 + 1" complexes with the [M(CO)3]+ (M = Re, 99mTc) tricarbonyl core for radiodiagnostic applications.

7. Sensing and inhibition of amyloid-β based on the simple luminescent aptamer-ruthenium complex system.

8. Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes.

9. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

10. Novel Bivalent 99mTc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy.

1. Design of a multivalent bifunctional chelator for diagnostic ⁶⁴Cu PET imaging in Alzheimer's disease.

2. Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-β plaques.

3. Bio-Evaluation of ^99mTc-Labeled Homodimeric Chalcone Derivative as Amyloid-β-Targeting Probe.

4. Al¹⁸F-NODA Benzothiazole Derivatives as Imaging Agents for Cerebrovascular Amyloid in Cerebral Amyloid Angiopathy.

5. A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation.