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Literature DB >> 26031493

MicroRNA as Biomarkers and Diagnostics.

Jin Wang¹, Jinyun Chen², Subrata Sen^1,3.

Abstract

MicroRNAs (miRNAs) are a group of small non-coding RNAs that are involved in regulating a range of developmental and physiological processes; their dysregulation has been associated with development of diseases including cancer. Circulating miRNAs and exosomal miRNAs have also been proposed as being useful in diagnostics as biomarkers for diseases and different types of cancer. In this review, miRNAs are discussed as biomarkers for cancer and other diseases, including viral infections, nervous system disorders, cardiovascular disorders, and diabetes. We summarize some of the clinical evidence for the use of miRNAs as biomarkers in diagnostics and provide some general perspectives on their use in clinical situations. The analytical challenges in using miRNAs in cancer and disease diagnostics are evaluated and discussed. Validation of specific miRNA signatures as biomarkers is a critical milestone in diagnostics.

Entities: Chemical

Mesh：

Substances：

Year: 2016 PMID： 26031493 PMCID： PMC8776330 DOI： 10.1002/jcp.25056

Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384

118 in total

Review 1. Circulating microRNA biomarker studies: pitfalls and potential solutions.

Authors: Kenneth W Witwer
Journal: Clin Chem Date: 2014-11-12 Impact factor: 8.327

2. Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients.

Authors: Evrim Anadol; Robert Schierwagen; Natalia Elfimova; Katharina Tack; Carolynne Schwarze-Zander; Hanna Eischeid; Andrea Noetel; Christoph Boesecke; Christian Jansen; Leona Dold; Jan-Christian Wasmuth; Christian P Strassburg; Ulrich Spengler; Jürgen Kurt Rockstroh; Margarete Odenthal; Jonel Trebicka
Journal: Hepatology Date: 2014-11-20 Impact factor: 17.425

3. MicroRNA gene expression deregulation in human breast cancer.

Authors: Marilena V Iorio; Manuela Ferracin; Chang-Gong Liu; Angelo Veronese; Riccardo Spizzo; Silvia Sabbioni; Eros Magri; Massimo Pedriali; Muller Fabbri; Manuela Campiglio; Sylvie Ménard; Juan P Palazzo; Anne Rosenberg; Piero Musiani; Stefano Volinia; Italo Nenci; George A Calin; Patrizia Querzoli; Massimo Negrini; Carlo M Croce
Journal: Cancer Res Date: 2005-08-15 Impact factor: 12.701

4. MicroRNA signature predicts survival and relapse in lung cancer.

Authors: Sung-Liang Yu; Hsuan-Yu Chen; Gee-Chen Chang; Chih-Yi Chen; Huei-Wen Chen; Sher Singh; Chiou-Ling Cheng; Chong-Jen Yu; Yung-Chie Lee; Han-Shiang Chen; Te-Jen Su; Ching-Cheng Chiang; Han-Ni Li; Qi-Sheng Hong; Hsin-Yuan Su; Chun-Chieh Chen; Wan-Jiun Chen; Chun-Chi Liu; Wing-Kai Chan; Wei J Chen; Ker-Chau Li; Jeremy J W Chen; Pan-Chyr Yang
Journal: Cancer Cell Date: 2008-01 Impact factor: 31.743

5. Accurate molecular characterization of formalin-fixed, paraffin-embedded tissues by microRNA expression profiling.

Authors: Anna E Szafranska; Timothy S Davison; Jaclyn Shingara; Martina Doleshal; Judith A Riggenbach; Carl D Morrison; Scott Jewell; Emmanuel Labourier
Journal: J Mol Diagn Date: 2008-08-07 Impact factor: 5.568

6. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction.

Authors: Jing Ai; Rong Zhang; Yue Li; Jielin Pu; Yanjie Lu; Jundong Jiao; Kang Li; Bo Yu; Zhuqin Li; Rongrong Wang; Lihong Wang; Qiang Li; Ning Wang; Hongli Shan; Zhongyu Li; Baofeng Yang
Journal: Biochem Biophys Res Commun Date: 2009-11-05 Impact factor: 3.575

7. Early second-trimester serum miRNA profiling predicts gestational diabetes mellitus.

Authors: Chun Zhao; Jing Dong; Tao Jiang; Zhonghua Shi; Bin Yu; Yunlong Zhu; Daozhen Chen; Junrong Xu; Ran Huo; Juncheng Dai; Yankai Xia; Shiyang Pan; Zhibin Hu; Jiahao Sha
Journal: PLoS One Date: 2011-08-24 Impact factor: 3.240

8. Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer.

Authors: Jin Wang; Massimo Raimondo; Sushovan Guha; Jinyun Chen; Lixia Diao; Xiaoqun Dong; Michael B Wallace; Ann M Killary; Marsha L Frazier; Timothy A Woodward; Jing Wang; Subrata Sen
Journal: J Cancer Date: 2014-09-16 Impact factor: 4.207

9. The role of circulating microRNA-126 (miR-126): a novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus.

Authors: Yang Liu; Guangqiang Gao; Chun Yang; Kun Zhou; Baozhong Shen; Hongyan Liang; Xiaofeng Jiang
Journal: Int J Mol Sci Date: 2014-06-12 Impact factor: 5.923

10. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.

Authors: Lorenzo F Sempere; Sarah Freemantle; Ian Pitha-Rowe; Eric Moss; Ethan Dmitrovsky; Victor Ambros
Journal: Genome Biol Date: 2004-02-16 Impact factor: 13.583

206 in total

1. SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery.

Authors: Siwen Hu-Lieskovan; Srabani Bhaumik; Kavita Dhodapkar; Jean-Charles J B Grivel; Sumati Gupta; Brent A Hanks; Sylvia Janetzki; Thomas O Kleen; Yoshinobu Koguchi; Amanda W Lund; Cristina Maccalli; Yolanda D Mahnke; Ruslan D Novosiadly; Senthamil R Selvan; Tasha Sims; Yingdong Zhao; Holden T Maecker
Journal: J Immunother Cancer Date: 2020-12 Impact factor: 13.751

2. MicroRNAs and cholangiocarcinoma: elucidating the effects of tiny giants.

Authors: Vik Meadows; Heather Francis
Journal: AME Med J Date: 2018-10-04

Review 3. Striking the right immunological balance prevents progression of tuberculosis.

Authors: Shachi Pranjal Vyas; Ritobrata Goswami
Journal: Inflamm Res Date: 2017-07-15 Impact factor: 4.575

4. Expanding the Dynamic Range of Fluorescence Assays through Single-Molecule Counting and Intensity Calibration.

Authors: Lucas Smith; Manish Kohli; Andrew M Smith
Journal: J Am Chem Soc Date: 2018-10-12 Impact factor: 15.419

Review 5. Markers of Immune Function in Heart Transplantation: Implications for Immunosuppression and Screening for Rejection.

Authors: David X Zhuo; Katie Ginder; E Ashley Hardin
Journal: Curr Heart Fail Rep Date: 2021-01-05