| Literature DB >> 27155217 |
Hyejin Yoon1, Luis F Flores2, Jungsu Kim3.
Abstract
Cholesterol is important for various neuronal functions in the brain. Brain has elaborate regulatory mechanisms to control cholesterol metabolism that are distinct from the mechanisms in periphery. Interestingly, dysregulation of the cholesterol metabolism is strongly associated with a number of neurodegenerative diseases. MicroRNAs are short non-coding RNAs acting as post-transcriptional gene regulators. Recently, several microRNAs are demonstrated to be involved in regulating cholesterol metabolism in the brain. This article reviews the regulatory mechanisms of cellular cholesterol homeostasis in the brain. In addition, we discuss the role of microRNAs in brain cholesterol metabolism and their potential implications for the treatment of Alzheimer's disease. This article is part of a special issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.Entities:
Keywords: Alzheimer's disease; Central nervous system; Cholesterol metabolism; Lipid metabolism; MicroRNA
Mesh：
Substances：
Year: 2016 PMID： 27155217 PMCID： PMC5097035 DOI： 10.1016/j.bbalip.2016.04.020
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002