Shimpei Ogawa1, Michio Itabashi2, Chisato Kondo3, Mitsuru Momose3, Shuji Sakai3, Shingo Kameoka1. 1. Department of Surgery II, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan. 2. Department of Surgery II, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan itabashi@surg2.twmu.ac.jp. 3. Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Abstract
AIM: [(18)F]Fluorodeoxyglucose positron-emission tomography with computed tomography ((18)F-FDG-PET/CT) was assessed regarding its utility in prediction of outcomes after curative resection of colorectal cancer. PATIENTS AND METHODS: Preoperative (18)F-FDG-PET/CT was performed in 325 patients with colorectal cancer. Maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic volume (MV), and total lesion glycolysis (TLG) were measured. Patients were divided into groups using cut-offs for overall survival (OS). (18)F-FDG-PET/CT parameters and other clinicopathological factors were investigated as prognostic factors. RESULTS: The 5-year OS rates in the low and high SUVmax, SUVmean, MV, and TLG groups were 91.4% and 87.0% (p=0.238), 90.8% and 88.2% (p=0.453), 91.7% and 83.8% (p=0.006), and 92.1% and 70.1% (p=0.001), respectively, indicating poorer outcomes in patients with high MV and TLG. In multivariate analysis, high TLG, age ≥65 years, rectal tumor location, and pN(+) were independent factors predicting a poor prognosis. CONCLUSION: TLG in (18)F-FDG-PET/CT is a prognostic parameter for colorectal cancer after curative resection. Copyright
AIM: [(18)F]Fluorodeoxyglucose positron-emission tomography with computed tomography ((18)F-FDG-PET/CT) was assessed regarding its utility in prediction of outcomes after curative resection of colorectal cancer. PATIENTS AND METHODS: Preoperative (18)F-FDG-PET/CT was performed in 325 patients with colorectal cancer. Maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic volume (MV), and total lesion glycolysis (TLG) were measured. Patients were divided into groups using cut-offs for overall survival (OS). (18)F-FDG-PET/CT parameters and other clinicopathological factors were investigated as prognostic factors. RESULTS: The 5-year OS rates in the low and high SUVmax, SUVmean, MV, and TLG groups were 91.4% and 87.0% (p=0.238), 90.8% and 88.2% (p=0.453), 91.7% and 83.8% (p=0.006), and 92.1% and 70.1% (p=0.001), respectively, indicating poorer outcomes in patients with high MV and TLG. In multivariate analysis, high TLG, age ≥65 years, rectal tumor location, and pN(+) were independent factors predicting a poor prognosis. CONCLUSION:TLG in (18)F-FDG-PET/CT is a prognostic parameter for colorectal cancer after curative resection. Copyright
Authors: E J van Helden; Y J L Vacher; W N van Wieringen; F H P van Velden; H M W Verheul; O S Hoekstra; R Boellaard; C W Menke-van der Houven van Oordt Journal: Eur J Nucl Med Mol Imaging Date: 2018-08-09 Impact factor: 9.236
Authors: Balaji Ganeshan; Kenneth Miles; Asim Afaq; Shonit Punwani; Manuel Rodriguez; Simon Wan; Darren Walls; Luke Hoy; Saif Khan; Raymond Endozo; Robert Shortman; John Hoath; Aman Bhargava; Matthew Hanson; Daren Francis; Tan Arulampalam; Sanjay Dindyal; Shih-Hsin Chen; Tony Ng; Ashley Groves Journal: Cancers (Basel) Date: 2021-05-31 Impact factor: 6.639