BACKGROUND: Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with ischemic cardiomyopathy and long QT syndrome. However, the role of MD in patients with non-ischemic cardiomyopathy (NICM) has not yet been studied. METHODS AND RESULTS: In 20 patients with NICM (mean age 62 ± 11 years, 75 % male, mean EF 32 ± 6 %, mean QRS duration 102 ± 14 ms), we measured longitudinal strain by 2DS in a 16-segment left ventricular model and calculated the MD. Patients were divided into two groups, defined by the presence or absence of documented VT/VF. In 11 patients (55 %), VT/VF was documented. The median time from VT/VF to echocardiographic examination was 26 (IQR 15-58) months. There were no significant differences in baseline characteristics between patients with and without index events. MD was significantly greater in patients with VT/VF as compared to those without arrhythmias (84 ± 31 ms vs. 53 ± 16 ms, p = 0.017). The analysis of the ROC curve (AUC 0.81, 95 % CI 0.63-1.00, p = 0.017) revealed that dispersion >50 ms is associated with twelve times higher risk of VT/VF in patients with NICM (OR 12.5, 95 % CI 1.1-143.4, p = 0.024). CONCLUSIONS: In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF.
BACKGROUND: Mechanical dispersion (MD), defined as the standard deviation of time to maximum myocardial shortening assessed by 2D speckle tracking echocardiographic strain imaging (2DS), has been recently proposed as a predictor for ventricular tachycardia or fibrillation (VT/VF) in patients with ischemic cardiomyopathy and long QT syndrome. However, the role of MD in patients with non-ischemic cardiomyopathy (NICM) has not yet been studied. METHODS AND RESULTS: In 20 patients with NICM (mean age 62 ± 11 years, 75 % male, mean EF 32 ± 6 %, mean QRS duration 102 ± 14 ms), we measured longitudinal strain by 2DS in a 16-segment left ventricular model and calculated the MD. Patients were divided into two groups, defined by the presence or absence of documented VT/VF. In 11 patients (55 %), VT/VF was documented. The median time from VT/VF to echocardiographic examination was 26 (IQR 15-58) months. There were no significant differences in baseline characteristics between patients with and without index events. MD was significantly greater in patients with VT/VF as compared to those without arrhythmias (84 ± 31 ms vs. 53 ± 16 ms, p = 0.017). The analysis of the ROC curve (AUC 0.81, 95 % CI 0.63-1.00, p = 0.017) revealed that dispersion >50 ms is associated with twelve times higher risk of VT/VF in patients with NICM (OR 12.5, 95 % CI 1.1-143.4, p = 0.024). CONCLUSIONS: In this small cohort of NICM patients, greater MD was associated with a higher incidence of VT/VF.
Authors: M A Quiñones; B H Greenberg; H A Kopelen; C Koilpillai; M C Limacher; D M Shindler; B J Shelton; D H Weiner Journal: J Am Coll Cardiol Date: 2000-04 Impact factor: 24.094
Authors: Johannes H Riffel; Marius G P Keller; Matthias Aurich; Yannick Sander; Florian Andre; Sorin Giusca; Fabian Aus dem Siepen; Sebastian Seitz; Christian Galuschky; Grigorios Korosoglou; Derliz Mereles; Hugo A Katus; Sebastian J Buss Journal: Clin Res Cardiol Date: 2015-02-03 Impact factor: 5.460
Authors: Kristina H Haugaa; Marit Kristine Smedsrud; Torkel Steen; Erik Kongsgaard; Jan Pål Loennechen; Terje Skjaerpe; Jens-Uwe Voigt; Rik Willems; Gunnar Smith; Otto A Smiseth; Jan P Amlie; Thor Edvardsen Journal: JACC Cardiovasc Imaging Date: 2010-03
Authors: Oscar Cano; Mathew Hutchinson; David Lin; Fermin Garcia; Erica Zado; Rupa Bala; Michael Riley; Joshua Cooper; Sanjay Dixit; Edward Gerstenfeld; David Callans; Francis E Marchlinski Journal: J Am Coll Cardiol Date: 2009-08-25 Impact factor: 24.094
Authors: M Emond; M B Mock; K B Davis; L D Fisher; D R Holmes; B R Chaitman; G C Kaiser; E Alderman; T Killip Journal: Circulation Date: 1994-12 Impact factor: 29.690
Authors: Thor Edvardsen; Bernhard L Gerber; Jérôme Garot; David A Bluemke; João A C Lima; Otto A Smiseth Journal: Circulation Date: 2002-07-02 Impact factor: 29.690
Authors: Alfred E Buxton; Kerry L Lee; Gail E Hafley; Luis A Pires; John D Fisher; Michael R Gold; Mark E Josephson; Michael H Lehmann; Eric N Prystowsky Journal: J Am Coll Cardiol Date: 2007-09-04 Impact factor: 24.094
Authors: Bahar Pirat; Dirar S Khoury; Craig J Hartley; Les Tiller; Liyun Rao; Daryl G Schulz; Sherif F Nagueh; William A Zoghbi Journal: J Am Coll Cardiol Date: 2008-02-12 Impact factor: 24.094
Authors: Heike E Schneider; Michael Steinmetz; Ulrich Krause; Thomas Kriebel; Wolfgang Ruschewski; Thomas Paul Journal: Clin Res Cardiol Date: 2012-07-21 Impact factor: 5.460
Authors: Kristina Hermann Haugaa; Thor Edvardsen; Trond P Leren; Jon Michael Gran; Otto A Smiseth; Jan P Amlie Journal: Eur Heart J Date: 2008-10-21 Impact factor: 29.983