Literature DB >> 25983516

Scurvy in pediatric age group - A disease often forgotten?

Anil Agarwal1, Abbas Shaharyar2, Anubrat Kumar2, Mohd Shafi Bhat2, Madhusudan Mishra3.   

Abstract

Scurvy is caused by prolonged severe dietary deficiency of vitamin C. Being rare as compared to other nutritional deficiencies, it is seldom suspected and this frequently leads to delayed recognition of this disorder. Children with abnormal dietary habits, mental illness or physical disabilities are prone to develop this disease. The disease spectrum of scurvy is quite varied and includes dermatological, dental, bone and systemic manifestations. Subperiosteal hematoma, ring epiphysis, metaphyseal white line and rarefaction zone along with epiphyseal slips are common radiological findings. High index of suspicion, detailed history and bilateral limb radiographs aids physician in diagnosing this eternal masquerader. We searched Pubmed for recent literature (2009-2014) with search terms "scurvy" "vitamin C deficiency" "ascorbic acid deficiency" "scurvy and children" "scurvy and pediatric age group". There were a total of 36 articles relevant to pediatric scurvy in children (7 reviews and 29 case reports) which were retrieved. The review briefly recapitulates the role of vitamin C, the various disease manifestations and the treatment of scurvy to create awareness of the disease which still is reported from our country, although sporadically. The recent advances related to scurvy and its management in pediatric age group are also incorporated.

Entities:  

Keywords:  Ascorbic acid; Children; Pediatric age group; Scurvy; Vitamin C

Year:  2015        PMID: 25983516      PMCID: PMC4411344          DOI: 10.1016/j.jcot.2014.12.003

Source DB:  PubMed          Journal:  J Clin Orthop Trauma        ISSN: 0976-5662


  36 in total

1.  Case records of the Massachusetts General Hospital. Case 23-2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy.

Authors:  Christopher P Duggan; Sjirk J Westra; Andrew E Rosenberg
Journal:  N Engl J Med       Date:  2007-07-26       Impact factor: 91.245

Review 2.  Scurvy: reemergence of nutritional deficiencies.

Authors:  Daniel Léger
Journal:  Can Fam Physician       Date:  2008-10       Impact factor: 3.275

3.  A highly selective and instantaneous nanoprobe for detection and imaging of ascorbic acid in living cells and in vivo.

Authors:  Na Li; Yanhua Li; Yaoyao Han; Wei Pan; Tingting Zhang; Bo Tang
Journal:  Anal Chem       Date:  2014-04-01       Impact factor: 6.986

4.  Scurvy presenting as pseudoparalysis.

Authors:  Sohail Ahmad; Mohammad Zahid; Hatif Q Siddiqui; Gaurav Gupta
Journal:  Saudi Med J       Date:  2011-07       Impact factor: 1.484

Review 5.  Musculoskeletal manifestations of scurvy.

Authors:  Olivier Fain
Journal:  Joint Bone Spine       Date:  2005-03       Impact factor: 4.929

6.  Spontaneous bilateral distal femoral physiolysis due to scurvy.

Authors:  J Nerubay; D Pilderwasser
Journal:  Acta Orthop Scand       Date:  1984-02

7.  Inability to walk due to scurvy: A forgotten disease.

Authors:  Hussein A Algahtani; Abduljaleel P Abdu; Imad M Khojah; Ali M Al-Khathaami
Journal:  Ann Saudi Med       Date:  2010 Jul-Aug       Impact factor: 1.526

8.  Case report: scurvy in an epileptic child on a ketogenic diet with oral complications.

Authors:  N S Willmott; R A E Bryan
Journal:  Eur Arch Paediatr Dent       Date:  2008-09

9.  Scurvy: presenting as musculoskeletal pain.

Authors:  Attia Bari; Bushra Karim Javaid; Saira Rehman; Samia Naz
Journal:  J Coll Physicians Surg Pak       Date:  2009-03       Impact factor: 0.711

10.  Treatment of pain in juvenile idiopathic arthritis: a survey of pediatric rheumatologists.

Authors:  Yukiko Kimura; Gary A Walco; Etan Sugarman; Paola M Conte; Laura E Schanberg
Journal:  Arthritis Rheum       Date:  2006-02-15
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  28 in total

1.  End stage scurvy in the developed world: A diagnostic conundrum but not to be mistaken for pyoderma gangrenosum.

Authors:  Stephanie T Le; Jenny Z Wang; Claire C Alexanian; Stephanie Y Johng; Forum B Patel; Elizabeth A Wang; Chelsea Ma; Reason Wilken; Michelle Y Cheng; Emanual Maverakis
Journal:  Int Wound J       Date:  2019-06-02       Impact factor: 3.315

Review 2.  Defining 'nutraceuticals': neither nutritious nor pharmaceutical.

Authors:  Jeffrey K Aronson
Journal:  Br J Clin Pharmacol       Date:  2016-04-25       Impact factor: 4.335

3.  Bibliometric analysis of the top 50 most cited publications of the Journal of Clinical Orthopaedics and Trauma.

Authors:  Karthik Vishwanathan; Srinivas B S Kambhampati; Mohit Kumar Patralekh; Abhishek Vaish; Raju Vaishya
Journal:  J Clin Orthop Trauma       Date:  2021-09-13

4.  Brief Report: Scurvy as a Manifestation of Food Selectivity in Children with Autism.

Authors:  Nina S Ma; Cynthia Thompson; Sharon Weston
Journal:  J Autism Dev Disord       Date:  2016-04

5.  Hematologic Manifestations of Nutritional Deficiencies: Early Recognition is Essential to Prevent Serious Complications.

Authors:  Jennifer C Yu; Ksenya Shliakhtsitsava; YunZu M Wang; Megan Paul; Lauge Farnaes; Victor Wong; Jenny Kim; Courtney D Thornburg
Journal:  J Pediatr Hematol Oncol       Date:  2019-04       Impact factor: 1.289

6.  Scurvy: an unusual complication of paediatric cancer treatment.

Authors:  Iain Irvine; Triona Walshe; Michael Capra; Roisin Hayes
Journal:  Skeletal Radiol       Date:  2018-10-29       Impact factor: 2.199

7.  Is it leukemia, doctor? No, it's scurvy induced by an ARFID!

Authors:  Sarah Benezech; Chrystele Hartmann; Diane Morfin; Yves Bertrand; Carine Domenech
Journal:  Eur J Clin Nutr       Date:  2020-04-20       Impact factor: 4.016

8.  Initial Evidence of Variation by Ethnicity in the Relationship between Vitamin C Status and Mental States in Young Adults.

Authors:  Benjamin D Fletcher; Jayde A M Flett; Shay-Ruby Wickham; Juliet M Pullar; Margreet C M Vissers; Tamlin S Conner
Journal:  Nutrients       Date:  2021-02-27       Impact factor: 5.717

9.  Adult Scurvy Presenting with Painful Purpura on the Legs.

Authors:  Nayu Tamura; Takafumi Obara; Taihei Yamada; Tsuyoshi Nojima; Shunsuke Nakamura; Yasuhiro Koide; Makoto Takaoka; Hiromichi Naito; Atsunori Nakao
Journal:  Intern Med       Date:  2021-11-13       Impact factor: 1.282

Review 10.  Vitamin C Deficiency in the Young Brain-Findings from Experimental Animal Models.

Authors:  Pernille Tveden-Nyborg
Journal:  Nutrients       Date:  2021-05-15       Impact factor: 5.717

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