Literature DB >> 30374635

Scurvy: an unusual complication of paediatric cancer treatment.

Iain Irvine1, Triona Walshe2, Michael Capra3, Roisin Hayes2.   

Abstract

Scurvy is a disease that is rarely encountered in modern medicine. A condition that was classically associated with sailors, its incidence has decreased dramatically since the discovery of its association with vitamin C deficiency. We present the case of a 2-year-old boy, whose treatment for neuroblastoma was complicated by gastrointestinal disease, which necessitated enteral feeding. While still undergoing treatment, he started to complain about increasing pain in his lower limbs, which appeared to be markedly tender on palpation. Radiographic findings suggested a diagnosis of scurvy, which was subsequently confirmed on serum biochemistry. This was an unexpected finding, as the child had been receiving adequate vitamin C in his enteral feeds. However, his absorption had become severely impaired due to pseudomembranous gastritis and enteritis, leading to his deficient state. He significantly improved after intravenous ascorbic acid replacement and demonstrated a full recovery, both clinically and radiologically. This case highlights the importance of considering scurvy in the differential diagnosis for at-risk patients. Early recognition can facilitate the simple treatment of this potentially serious condition.

Entities:  

Keywords:  Enteral feeding; Neuroblastoma; Scurvy; Vitamin C deficiency

Mesh:

Substances:

Year:  2018        PMID: 30374635     DOI: 10.1007/s00256-018-3103-5

Source DB:  PubMed          Journal:  Skeletal Radiol        ISSN: 0364-2348            Impact factor:   2.199


  11 in total

1.  Multiple micronutrient deficiencies in a child fed an elemental formula.

Authors:  M Jones; K A Campbell; C Duggan; G Young; A Bousvaros; L Higgins; E Mullen
Journal:  J Pediatr Gastroenterol Nutr       Date:  2001-11       Impact factor: 2.839

2.  Scarcity in the midst of plenty: enteral tube feeding complicated by scurvy.

Authors:  S R Gorman; G Armstrong; K R Allen; J Ellis; J W L Puntis
Journal:  J Pediatr Gastroenterol Nutr       Date:  2002-07       Impact factor: 2.839

Review 3.  Scurvy: a disease almost forgotten.

Authors:  Jesse M Olmedo; James A Yiannias; Elizabeth B Windgassen; Michael K Gornet
Journal:  Int J Dermatol       Date:  2006-08       Impact factor: 2.736

Review 4.  Musculoskeletal manifestations of scurvy.

Authors:  Olivier Fain
Journal:  Joint Bone Spine       Date:  2005-03       Impact factor: 4.929

5.  Treatment of iron-deficiency anemia complicated by scurvy and folic acid deficiency.

Authors:  N G Clark; N F Sheard; J F Kelleher
Journal:  Nutr Rev       Date:  1992-05       Impact factor: 7.110

6.  An orange a day keeps the doctor away: scurvy in the year 2000.

Authors:  M Weinstein; P Babyn; S Zlotkin
Journal:  Pediatrics       Date:  2001-09       Impact factor: 7.124

Review 7.  Scurvy in pediatric age group - A disease often forgotten?

Authors:  Anil Agarwal; Abbas Shaharyar; Anubrat Kumar; Mohd Shafi Bhat; Madhusudan Mishra
Journal:  J Clin Orthop Trauma       Date:  2015-01-05

Review 8.  Imaging Findings of Metabolic Bone Disease.

Authors:  Connie Y Chang; Daniel I Rosenthal; Deborah M Mitchell; Atsuhiko Handa; Susan V Kattapuram; Ambrose J Huang
Journal:  Radiographics       Date:  2016-10       Impact factor: 5.333

9.  Scurvy: a new problem for patients with chronic GVHD involving mucous membranes; an easy problem to resolve.

Authors:  Morris Kletzel; Kim Powers; Meghan Hayes
Journal:  Pediatr Transplant       Date:  2014-05-12

Review 10.  MRI findings in pediatric patients with scurvy.

Authors:  Edwin Gulko; Lee K Collins; Robyn C Murphy; Beverly A Thornhill; Benjamin H Taragin
Journal:  Skeletal Radiol       Date:  2014-08-12       Impact factor: 2.199

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.