Literature DB >> 31154667

End stage scurvy in the developed world: A diagnostic conundrum but not to be mistaken for pyoderma gangrenosum.

Stephanie T Le1, Jenny Z Wang1,2, Claire C Alexanian1,3, Stephanie Y Johng3, Forum B Patel1, Elizabeth A Wang1, Chelsea Ma1, Reason Wilken1, Michelle Y Cheng1, Emanual Maverakis1.   

Abstract

Scurvy is a clinical syndrome, resulting from ascorbic acid deficiency. Prevalence of the condition is now extremely low in the Western population and its diagnosis can be challenging without a high index of suspicion. When cases do present, they are often misdiagnosed initially. Therefore, a thorough history, physical exam, and laboratory evaluation are key to showing this now rare but extremely well-known disease. We report a case of scurvy manifesting as persistent non-healing lower-extremity ulcerations, initially mistaken for pyoderma gangrenosum. The patient responded to appropriate replacement therapy, but ulcers were slow to heal. As was the case in our patient, symptom reversal may require additional nutritional replacement. We encourage physicians to consider nutritional deficiencies in their differential diagnoses and highlight the incidence of malnutrition in the proper clinical setting to avoid diagnostic delay.
© 2019 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Entities:  

Keywords:  ascorbic acid; pyoderma gangrenosum; scurvy; ulcers; wound healing

Mesh:

Substances:

Year:  2019        PMID: 31154667      PMCID: PMC7949452          DOI: 10.1111/iwj.13149

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  18 in total

Review 1.  The Value of the History and Physical Examination--Sailing Through Medicine With Modern Tools: A Teachable Moment.

Authors:  Maen D Abou Ziki; David N Podell; Danise M Schiliro
Journal:  JAMA Intern Med       Date:  2015-12       Impact factor: 21.873

Review 2.  Rheumatic manifestations of scurvy: a report of three recent cases in a major urban center and a review.

Authors:  Marty T Mertens; Elie Gertner
Journal:  Semin Arthritis Rheum       Date:  2010-12-23       Impact factor: 5.532

3.  The rapidly evolving lesions of ulcerative pyoderma gangrenosum: a timeline.

Authors:  Elizabeth A Wang; Emanual Maverakis
Journal:  Int J Dermatol       Date:  2018-05-27       Impact factor: 2.736

Review 4.  Skin ulcers misdiagnosed as pyoderma gangrenosum.

Authors:  Roger H Weenig; Mark D P Davis; Patrick R Dahl; W P Daniel Su
Journal:  N Engl J Med       Date:  2002-10-31       Impact factor: 91.245

5.  End stage scurvy in the developed world: A diagnostic conundrum but not to be mistaken for pyoderma gangrenosum.

Authors:  Stephanie T Le; Jenny Z Wang; Claire C Alexanian; Stephanie Y Johng; Forum B Patel; Elizabeth A Wang; Chelsea Ma; Reason Wilken; Michelle Y Cheng; Emanual Maverakis
Journal:  Int Wound J       Date:  2019-06-02       Impact factor: 3.315

Review 6.  Adult scurvy.

Authors:  J V Hirschmann; G J Raugi
Journal:  J Am Acad Dermatol       Date:  1999-12       Impact factor: 11.527

Review 7.  Effective strategies for the management of pyoderma gangrenosum: a comprehensive review.

Authors:  Forum Patel; Sarah Fitzmaurice; Christopher Duong; Young He; Jonathan Fergus; Siba P Raychaudhuri; Miki Shirakawa Garcia; Emanual Maverakis
Journal:  Acta Derm Venereol       Date:  2015-05       Impact factor: 4.437

Review 8.  Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria.

Authors:  W P Daniel Su; Mark D P Davis; Roger H Weenig; Frank C Powell; Harold O Perry
Journal:  Int J Dermatol       Date:  2004-11       Impact factor: 2.736

9.  Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts.

Authors:  Emanual Maverakis; Chelsea Ma; Kanade Shinkai; David Fiorentino; Jeffrey P Callen; Uwe Wollina; Angelo Valerio Marzano; Daniel Wallach; Kyoungmi Kim; Courtney Schadt; Anthony Ormerod; Maxwell A Fung; Andrea Steel; Forum Patel; Rosie Qin; Fiona Craig; Hywel C Williams; Frank Powell; Alexander Merleev; Michelle Y Cheng
Journal:  JAMA Dermatol       Date:  2018-04-01       Impact factor: 10.282

10.  Scurvy: historical review and current diagnostic approach.

Authors:  Laura Pimentel
Journal:  Am J Emerg Med       Date:  2003-07       Impact factor: 2.469

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  1 in total

1.  End stage scurvy in the developed world: A diagnostic conundrum but not to be mistaken for pyoderma gangrenosum.

Authors:  Stephanie T Le; Jenny Z Wang; Claire C Alexanian; Stephanie Y Johng; Forum B Patel; Elizabeth A Wang; Chelsea Ma; Reason Wilken; Michelle Y Cheng; Emanual Maverakis
Journal:  Int Wound J       Date:  2019-06-02       Impact factor: 3.315

  1 in total

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