Literature DB >> 25960127

Engineered biosynthesis of natural products in heterologous hosts.

Yunzi Luo1, Bing-Zhi Li, Duo Liu, Lu Zhang, Yan Chen, Bin Jia, Bo-Xuan Zeng, Huimin Zhao, Ying-Jin Yuan.   

Abstract

Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.

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Year:  2015        PMID： 25960127      PMCID： PMC4510016          DOI： 10.1039/c5cs00025d

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  180 in total

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  41 in total

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9.  Functional Promiscuity of Two Divergent Paralogs of Type III Plant Polyketide Synthases.

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Review 10.  New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters.

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