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Literature DB >> 25938936

Optimized diazo scaffold for protein esterification.

Abstract

The O-alkylation of carboxylic acids with diazo compounds provides a means to esterify carboxylic acids in aqueous solution. A Hammett analysis of the reactivity of diazo compounds derived from phenylglycinamide revealed that the (p-methylphenyl)glycinamide scaffold has an especially high reaction rate and ester/alcohol product ratio and esterifies protein carboxyl groups more efficiently than any known reagent.

Entities: Chemical Gene Species

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Year: 2015 PMID： 25938936 PMCID： PMC4670563 DOI： 10.1021/acs.orglett.5b00840

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

21 in total

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16 in total

1. Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs.

Authors: Eileen G Burke; Brian Gold; Trish T Hoang; Ronald T Raines; Jennifer M Schomaker
Journal: J Am Chem Soc Date: 2017-05-31 Impact factor: 15.419

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Journal: J Org Chem Date: 2019-05-30 Impact factor: 4.354

4. Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.

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Journal: Biochemistry Date: 2017-06-16 Impact factor: 3.162

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9. Development and Application of a Recyclable High-Load Magnetic Co/C Hybrid ROMP-Derived Benzenesulfonyl Chloride Reagent and Utility of Corresponding Analogues.

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Authors: Kalie A Mix; Jo E Lomax; Ronald T Raines
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