PURPOSE: Evaluate the discal morpho-structural changes as a predictive sign in the clinical outcome after ozone therapy in lumbar disc herniation using the T2-shine through effect in diffusion-weighted imaging (DWI). METHOD: One hundred and fifty-four patients suffering from lumbosciatica (89 men and 65 women; age range, 23-62 years) were included, previous MR study performed with FSE-T2 and T2-fat, SE-T1 and DWI sequences, and were randomly assigned to two groups. Seventy-seven patients (control group) underwent conservative treatment with intraforaminal injection of steroid and anaesthetic. The remaining 77 patients (study group) underwent the same treatment with the addition of oxygen-ozone (O2-O3). During the following six months, a MRI follow-up with the same sequences was performed. An intervertebral disc volumetric analysis (IDVA), DWI signal score and post treatment clinical outcome evaluation were performed for an assessment of hernia reduction. χ² test, Student's t test and analysis of covariance were used for comparison of variables. RESULTS: In the study group, 58 of 77 patients had a successful outcome (responders). In the responders group, DWI T2-shine through effect was present during MRI follow-up and in particular in 53 of 77 patients in six months of follow-up (p < 0.05). Moreover, in the same group a statistically significant disc shrinkage was shown by IDVA in sixth months of follow-up (p < 0.05). CONCLUSIONS:T2-shine through effect in DWI is present before morphological disc reduction and moreover could be considered as a predictive sign of response to oxygen-ozone treatment.
RCT Entities:
PURPOSE: Evaluate the discal morpho-structural changes as a predictive sign in the clinical outcome after ozone therapy in lumbar disc herniation using the T2-shine through effect in diffusion-weighted imaging (DWI). METHOD: One hundred and fifty-four patients suffering from lumbosciatica (89 men and 65 women; age range, 23-62 years) were included, previous MR study performed with FSE-T2 and T2-fat, SE-T1 and DWI sequences, and were randomly assigned to two groups. Seventy-seven patients (control group) underwent conservative treatment with intraforaminal injection of steroid and anaesthetic. The remaining 77 patients (study group) underwent the same treatment with the addition of oxygen-ozone (O2-O3). During the following six months, a MRI follow-up with the same sequences was performed. An intervertebral disc volumetric analysis (IDVA), DWI signal score and post treatment clinical outcome evaluation were performed for an assessment of hernia reduction. χ² test, Student's t test and analysis of covariance were used for comparison of variables. RESULTS: In the study group, 58 of 77 patients had a successful outcome (responders). In the responders group, DWI T2-shine through effect was present during MRI follow-up and in particular in 53 of 77 patients in six months of follow-up (p < 0.05). Moreover, in the same group a statistically significant disc shrinkage was shown by IDVA in sixth months of follow-up (p < 0.05). CONCLUSIONS: T2-shine through effect in DWI is present before morphological disc reduction and moreover could be considered as a predictive sign of response to oxygen-ozone treatment.
Authors: Roland Bammer; Andreas M Herneth; Stephan E Maier; Kim Butts; Rupert W Prokesch; Huy M Do; Scott W Atlas; Michael E Moseley Journal: AJNR Am J Neuroradiol Date: 2003-01 Impact factor: 3.825
Authors: Cosma F Andreula; Luigi Simonetti; Fabio De Santis; Raffaele Agati; Renata Ricci; Marco Leonardi Journal: AJNR Am J Neuroradiol Date: 2003-05 Impact factor: 3.825
Authors: A Splendiani; F D'Orazio; L Patriarca; F Arrigoni; F Caranci; P Fonio; L Brunese; A Barile; E Di Cesare; C Masciocchi Journal: Musculoskelet Surg Date: 2017-02-06
Authors: Antonio Barile; Alice La Marra; Francesco Arrigoni; Silvia Mariani; Luigi Zugaro; Alessandra Splendiani; Ernesto Di Cesare; Alfonso Reginelli; Marcello Zappia; Luca Brunese; Ejona Duka; Giampaolo Carrafiello; Carlo Masciocchi Journal: Br J Radiol Date: 2016-07-07 Impact factor: 3.039
Authors: Federico Bruno; Fernando Smaldone; Marco Varrassi; Francesco Arrigoni; Antonio Barile; Ernesto Di Cesare; Carlo Masciocchi; Alessandra Splendiani Journal: Interv Neuroradiol Date: 2017-05-09 Impact factor: 1.610
Authors: Alessandra Splendiani; Marco Perri; Giuseppe Grattacaso; Valeria Di Tunno; Claudia Marsecano; Luca Panebianco; Antonio Gennarelli; Valentina Felli; Marco Varrassi; Antonio Barile; Ernesto Di Cesare; Carlo Masciocchi; Massimo Gallucci Journal: Radiol Med Date: 2015-07-28 Impact factor: 3.469
Authors: Marco Perri; Claudia Marsecano; Marco Varrassi; Aldo Victor Giordano; Alessandra Splendiani; Ernesto di Cesare; Carlo Masciocchi; Massimo Gallucci Journal: Radiol Med Date: 2015-12-16 Impact factor: 3.469