Marco Perri1,2, Claudia Marsecano3,4, Marco Varrassi3,4, Aldo Victor Giordano3,4, Alessandra Splendiani3,5, Ernesto di Cesare3,4, Carlo Masciocchi3,4, Massimo Gallucci3,5. 1. S Salvatore Hospital, Coppito, 67100, L'Aquila, Italy. marco-perri@tiscali.it. 2. Division of Radiology, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy. marco-perri@tiscali.it. 3. S Salvatore Hospital, Coppito, 67100, L'Aquila, Italy. 4. Division of Radiology, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy. 5. Division of Neuroradiology, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy.
Abstract
OBJECTIVE: The aim of this study was to prospectively evaluate the clinical efficacy of perigangliar steroid and local anesthetic with intradiscal O2-O3 injection versus steroid and local anesthetic intraforaminal injection in different types of herniation and grade of disc degeneration. MATERIALS AND METHODS:A total of 517 patients were randomly assigned to two groups. Control Group (159 men, 101 women; age range 25-89 years) underwentsteroid and local anesthetic intraforaminal injection. Study Group (163 men, 94 women; age range 22-92 years) underwent the same treatment with addiction of O2-O3 intradiscal injection. Procedures were performed under computed tomographic guidance. Visual Analog Scale Questionnaire was administered before treatment and at intervals, the last at 6-month follow-up. Results were compared with Kruskal-Wallis and t test. RESULTS: After 6 months, O2-O3 discolysis was successful in 106 (41.24 %) Study Group patients with extrusions compared with 9 Control Group patients (3.5 %) (P < 0.001). In 89 (34.6 %) Study Group patients with protrusions, success rate was statistically significant compared with 5 Control Group patients (1.9 %). Significant difference was detected in the presence of Grade I, II, III of Degenerated Disc in 185 of Study Group patients (68.4 %) compared with 4 Control Group patients (1.5 %). CONCLUSIONS: The addition of O2-O3 discolysis is more effective at 6 months than perigangliar steroid and local anesthetic injection, especially in cases of herniated or protruded discs and with a Grade of Disc Degeneration from mild to moderate range.
RCT Entities:
OBJECTIVE: The aim of this study was to prospectively evaluate the clinical efficacy of perigangliar steroid and local anesthetic with intradiscal O2-O3 injection versus steroid and local anesthetic intraforaminal injection in different types of herniation and grade of disc degeneration. MATERIALS AND METHODS: A total of 517 patients were randomly assigned to two groups. Control Group (159 men, 101 women; age range 25-89 years) underwent steroid and local anesthetic intraforaminal injection. Study Group (163 men, 94 women; age range 22-92 years) underwent the same treatment with addiction of O2-O3 intradiscal injection. Procedures were performed under computed tomographic guidance. Visual Analog Scale Questionnaire was administered before treatment and at intervals, the last at 6-month follow-up. Results were compared with Kruskal-Wallis and t test. RESULTS: After 6 months, O2-O3 discolysis was successful in 106 (41.24 %) Study Group patients with extrusions compared with 9 Control Group patients (3.5 %) (P < 0.001). In 89 (34.6 %) Study Group patients with protrusions, success rate was statistically significant compared with 5 Control Group patients (1.9 %). Significant difference was detected in the presence of Grade I, II, III of Degenerated Disc in 185 of Study Group patients (68.4 %) compared with 4 Control Group patients (1.5 %). CONCLUSIONS: The addition of O2-O3 discolysis is more effective at 6 months than perigangliar steroid and local anesthetic injection, especially in cases of herniated or protruded discs and with a Grade of Disc Degeneration from mild to moderate range.
Authors: Christian W A Pfirrmann; Claudio Dora; Marius R Schmid; Marco Zanetti; Juerg Hodler; Norbert Boos Journal: Radiology Date: 2003-12-29 Impact factor: 11.105
Authors: Marco Perri; Giuseppe Grattacaso; Valeria di Tunno; Claudia Marsecano; Antonio Gennarelli; Giulia Michelini; Alessandra Splendiani; Ernesto Di Cesare; Carlo Masciocchi; Massimo Gallucci Journal: Radiol Med Date: 2015-03-06 Impact factor: 3.469
Authors: A Splendiani; F D'Orazio; L Patriarca; F Arrigoni; F Caranci; P Fonio; L Brunese; A Barile; E Di Cesare; C Masciocchi Journal: Musculoskelet Surg Date: 2017-02-06
Authors: Federico Bruno; Fernando Smaldone; Marco Varrassi; Francesco Arrigoni; Antonio Barile; Ernesto Di Cesare; Carlo Masciocchi; Alessandra Splendiani Journal: Interv Neuroradiol Date: 2017-05-09 Impact factor: 1.610
Authors: Alessandro de Sire; Francesco Agostini; Lorenzo Lippi; Massimiliano Mangone; Simone Marchese; Carlo Cisari; Andrea Bernetti; Marco Invernizzi Journal: Biomolecules Date: 2021-02-26
Authors: Alessandro Liguori; Federica Galli; Martina Gurgitano; Anna Borelli; Marco Pandolfi; Ferdinando Caranci; Alberto M Magenta Biasina; Giovanni G M Pompili; Claudia L Piccolo; Vittorio Miele; Carlo Masciocchi; Giampaolo Carrafiello Journal: Acta Biomed Date: 2018-01-19