Literature DB >> 25896388

Molybdopterin biosynthesis-Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP.

Angad P Mehta1, Sameh H Abdelwahed2, Tadhg P Begley3.   

Abstract

The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2' and C3' carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Intermediate trapping; Mechanism; MoaA; Molybtopterin; Substrate analog

Mesh：

Substances：

Year:  2015        PMID： 25896388      PMCID： PMC4506844          DOI： 10.1016/j.bbapap.2015.04.008

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


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