Biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdopterin from GTP. As a starting point, the discovery of molybdopterin and the elucidation of its structure through the study of stable degradation products are described. Subsequent to molybdopterin synthesis, the molybdenum atom is added to the molybdopterin dithiolene group to form the molybdenum cofactor. This cofactor is either inserted directly into specific molybdoenzymes or is further modified by the addition of nucleotides to the molybdopterin phosphate group or the replacement of ligands at the molybdenum center.
Biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdon class="Chemical">pterin from GTP. As a starting point, the discovery of molybdopterin and the elucidation of its structure through the study of stable degradation products are described. Subsequent to molybdopterin synthesis, the molybdenum atom is added to the molybdopterin dithiolene group to form the molybdenum cofactor. This cofactor is either inserted directly into specific molybdoenzymes or is further modified by the addition of nucleotides to the molybdopterin phosphate group or the replacement of ligands at the molybdenum center.
Authors: Günter Schwarz; José Angel Santamaria-Araujo; Stefan Wolf; Heon-Jin Lee; Ibrahim M Adham; Hermann-Josef Gröne; Herbert Schwegler; Jörn Oliver Sass; Tanja Otte; Petra Hänzelmann; Ralf R Mendel; Wolfgang Engel; Jochen Reiss Journal: Hum Mol Genet Date: 2004-04-28 Impact factor: 6.150
Authors: Angad P Mehta; Sameh H Abdelwahed; Nilkamal Mahanta; Dmytro Fedoseyenko; Benjamin Philmus; Lisa E Cooper; Yiquan Liu; Isita Jhulki; Steven E Ealick; Tadhg P Begley Journal: J Biol Chem Date: 2014-12-04 Impact factor: 5.157