Literature DB >> 23286307

Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA.

Angad P Mehta1, Jeremiah W Hanes, Sameh H Abdelwahed, David G Hilmey, Petra Hänzelmann, Tadhg P Begley.   

Abstract

MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2' and C3' of the ribose. This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for this unprecedented reaction.

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Year:  2013        PMID： 23286307      PMCID： PMC3582411          DOI： 10.1021/bi3016026

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  6 in total

1.  Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.

Authors:  Petra Hänzelmann; Hermann Schindelin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-21       Impact factor: 11.205

Review 2.  Molybdenum and tungsten in biology.

Authors:  Russ Hille
Journal:  Trends Biochem Sci       Date:  2002-07       Impact factor: 13.807

Review 3.  Molybdenum cofactor biosynthesis and molybdenum enzymes.

Authors:  Günter Schwarz; Ralf R Mendel
Journal:  Annu Rev Plant Biol       Date:  2006       Impact factor: 26.379

4.  ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications.

Authors:  Nicholas S Lees; Petra Hänzelmann; Heather L Hernandez; Sowmya Subramanian; Hermann Schindelin; Michael K Johnson; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2009-07-08       Impact factor: 15.419

5.  The structure of a molybdopterin precursor. Characterization of a stable, oxidized derivative.

Authors:  J L Johnson; M M Wuebbens; K V Rajagopalan
Journal:  J Biol Chem       Date:  1989-08-15       Impact factor: 5.157

6.  Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.

Authors:  Petra Hänzelmann; Hermann Schindelin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-18       Impact factor: 11.205
  6 in total
  24 in total

1.  X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification.

Authors:  Peter J Goldman; Tyler L Grove; Lauren A Sites; Martin I McLaughlin; Squire J Booker; Catherine L Drennan
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

Review 2.  Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions.

Authors:  Angad P Mehta; Sameh H Abdelwahed; Nilkamal Mahanta; Dmytro Fedoseyenko; Benjamin Philmus; Lisa E Cooper; Yiquan Liu; Isita Jhulki; Steven E Ealick; Tadhg P Begley
Journal:  J Biol Chem       Date:  2014-12-04       Impact factor: 5.157

3.  Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis.

Authors:  Bradley M Hover; Nam K Tonthat; Maria A Schumacher; Kenichi Yokoyama
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

Review 4.  The molybdenum cofactor.

Authors:  Ralf R Mendel
Journal:  J Biol Chem       Date:  2013-03-28       Impact factor: 5.157

5.  Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.

Authors:  Bradley M Hover; Anna Loksztejn; Anthony A Ribeiro; Kenichi Yokoyama
Journal:  J Am Chem Soc       Date:  2013-04-29       Impact factor: 15.419

Review 6.  The mononuclear molybdenum enzymes.

Authors:  Russ Hille; James Hall; Partha Basu
Journal:  Chem Rev       Date:  2014-01-28       Impact factor: 60.622

Review 7.  Radical S-adenosylmethionine enzymes.

Authors:  Joan B Broderick; Benjamin R Duffus; Kaitlin S Duschene; Eric M Shepard
Journal:  Chem Rev       Date:  2014-01-29       Impact factor: 60.622

Review 8.  The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria.

Authors:  Kenichi Yokoyama; Silke Leimkühler
Journal:  Biochim Biophys Acta       Date:  2014-09-28

9.  Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis.

Authors:  Haoran Pang; Kenichi Yokoyama
Journal:  Methods Enzymol       Date:  2018-06-01       Impact factor: 1.600

10.  Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue.

Authors:  Bradley M Hover; Edward A Lilla; Kenichi Yokoyama
Journal:  Biochemistry       Date:  2015-12-01       Impact factor: 3.162
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