| Literature DB >> 30394317 |
Alan J Mouton1, Osvaldo J Rivera Gonzalez1, Amanda R Kaminski1, Edwin T Moore1, Merry L Lindsey2.
Abstract
Following myocardial infarction (MI), timely resolution of inflammation promotes wound healing and scar formation while limiting excessive tissue damage. Resolution promoting factors (RPFs) are agents that blunt leukocyte trafficking and inflammation, promote necrotic and apoptotic cell clearance, and stimulate scar formation. Previously identified RPFs include mediators derived from lipids (resolvins, lipoxins, protectins, and maresins), proteins (glucocorticoids, annexin A1, galectin 1, and melanocortins), or gases (CO, H2S, and NO). Matrix metalloproteinase-12 (MMP-12; macrophage elastase) has shown promising RPF qualities in a variety of disease states. We review here the evidence that MMP-12 may serve as a novel RPF with potential therapeutic efficacy in the setting of MI.Entities:
Keywords: Extracellular matrix; Fibroblast; Inflammation; Inflammation resolution; Macrophage; Neutrophil
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Year: 2018 PMID: 30394317 PMCID: PMC6239213 DOI: 10.1016/j.phrs.2018.10.026
Source DB: PubMed Journal: Pharmacol Res ISSN: 1043-6618 Impact factor: 7.658