Sveta Shah Oza1, Vikas Pabby2, Laura E Dodge3, Vasiliki A Moragianni3, Michele R Hacker3, Janis H Fox4, Katharine Correia5, Stacey A Missmer6, Yetunde Ibrahim3, Alan S Penzias7, Robert Burakoff8, Sonia Friedman8, Adam S Cheifetz9. 1. Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts. 2. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California. 3. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts. 4. Department of Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts. 5. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. 6. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. 7. Reproductive Endocrinology and Infertility, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Reproductive Endocrinology and Infertility, Boston IVF, Boston, Massachusetts. 8. Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. 9. Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts. Electronic address: acheifet@bidmc.harvard.edu.
Abstract
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) affects women of reproductive age, so there are concerns about its effects on fertility. We investigated the success of in vitro fertilization (IVF) in patients with IBD compared with the general (non-IBD) IVF population. METHODS: We conducted a matched retrospective cohort study of female patients with IBD who underwent IVF from 1998 through 2011 at 2 tertiary care centers. Patients were matched 4:1 to those without IBD (controls). The primary outcome was the cumulative rate of live births after up to 6 cycles of IVF. Secondary outcomes included the proportion of patients who became pregnant and the rate of live births for each cycle. RESULTS: Forty-nine patients with Crohn's disease (CD), 71 patients with ulcerative colitis (UC), 1 patient with IBD-unclassified, and 470 controls underwent IVF during the study period. The cumulative rate of live births was 53% for controls, 69% for patients with UC (P = .08 compared with controls), and 57% for patients with CD (P = .87 compared with controls). The incidence of pregnancy after the first cycle of IVF was similar among controls (40.9%), patients with UC (49.3%; P = .18), and patients with CD (42.9%; P = .79). Similarly, the incidence of live births after the first cycle of IVF was similar among controls (30.2%), patients with UC (33.8%; P = .54), and patients with CD (30.6%; P = .95). CONCLUSIONS: Based on a matched cohort study, infertile women with IBD achieve a rate of live births after IVF that is comparable with those of infertile women without IBD.
BACKGROUND & AIMS:Inflammatory bowel disease (IBD) affects women of reproductive age, so there are concerns about its effects on fertility. We investigated the success of in vitro fertilization (IVF) in patients with IBD compared with the general (non-IBD) IVF population. METHODS: We conducted a matched retrospective cohort study of female patients with IBD who underwent IVF from 1998 through 2011 at 2 tertiary care centers. Patients were matched 4:1 to those without IBD (controls). The primary outcome was the cumulative rate of live births after up to 6 cycles of IVF. Secondary outcomes included the proportion of patients who became pregnant and the rate of live births for each cycle. RESULTS: Forty-nine patients with Crohn's disease (CD), 71 patients with ulcerative colitis (UC), 1 patient with IBD-unclassified, and 470 controls underwent IVF during the study period. The cumulative rate of live births was 53% for controls, 69% for patients with UC (P = .08 compared with controls), and 57% for patients with CD (P = .87 compared with controls). The incidence of pregnancy after the first cycle of IVF was similar among controls (40.9%), patients with UC (49.3%; P = .18), and patients with CD (42.9%; P = .79). Similarly, the incidence of live births after the first cycle of IVF was similar among controls (30.2%), patients with UC (33.8%; P = .54), and patients with CD (30.6%; P = .95). CONCLUSIONS: Based on a matched cohort study, infertile women with IBD achieve a rate of live births after IVF that is comparable with those of infertile women without IBD.
Authors: N Tavernier; M Fumery; L Peyrin-Biroulet; J-F Colombel; C Gower-Rousseau Journal: Aliment Pharmacol Ther Date: 2013-09-04 Impact factor: 8.171
Authors: Marie E Thoma; Alexander C McLain; Jean Fredo Louis; Rosalind B King; Ann C Trumble; Rajeshwari Sundaram; Germaine M Buck Louis Journal: Fertil Steril Date: 2013-01-03 Impact factor: 7.329
Authors: Vikas Pabby; Sveta Shah Oza; Laura E Dodge; Michele R Hacker; Vasiliki A Moragianni; Katherine Correia; Stacey A Missmer; Janis H Fox; Yetunde Ibrahim; Alan Penzias; Robert Burakoff; Adam Cheifetz; Sonia Friedman Journal: Am J Gastroenterol Date: 2014-12-16 Impact factor: 10.864
Authors: Sveta Shah Oza; Vikas Pabby; Laura E Dodge; Michele R Hacker; Janis H Fox; Vasiliki A Moragianni; Katharine Correia; Stacey A Missmer; Yetunde Ibrahim; Alan S Penzias; Robert Burakoff; Sonia Friedman; Adam S Cheifetz Journal: Dig Dis Sci Date: 2016-02-18 Impact factor: 3.199