Sveta Shah Oza1,2, Vikas Pabby3, Laura E Dodge2,4, Michele R Hacker4,5, Janis H Fox2,6, Vasiliki A Moragianni2,4, Katharine Correia2,6,7, Stacey A Missmer2,6,7,8, Yetunde Ibrahim2,4, Alan S Penzias5,9, Robert Burakoff2,10, Sonia Friedman2,10, Adam S Cheifetz11,12. 1. Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 2. Harvard Medical School, Boston, MA, USA. 3. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 4. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 5. Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA. 6. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA. 7. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. 8. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. 9. Division of Reproductive Endocrinology and Infertility, Beth Israel Deaconess Medical Center and Boston IVF, Boston, MA, USA. 10. Gastroenterology Division, Brigham and Women's Hospital, Boston, AM, USA. 11. Harvard Medical School, Boston, MA, USA. acheifet@bidmc.harvard.edu. 12. Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA. acheifet@bidmc.harvard.edu.
Abstract
BACKGROUND: It is unknown whether certain factors are associated with the success of in vitro fertilization (IVF) in women with inflammatory bowel disease (IBD). AIM: This study assessed whether certain characteristics are associated with greater success of live birth following IVF. METHODS: In a cohort study of 8684 women with IBD seen at two tertiary care centers, we identified 121 women with IBD who underwent IVF. We assessed the effect of numerous factors on likelihood of achieving live birth after IVF. RESULTS: Seventy-one patients with ulcerative colitis (UC) and 49 patients with Crohn's disease (CD) were analyzed. Patients with UC who achieved a live birth were younger (p = 0.03), had a shorter duration of disease (p = 0.01), and were more likely to be in remission (p = 0.03) versus those who did not achieve live birth. Patients with CD who achieved live birth were younger (p < 0.001), had lower body mass index (BMI) (p = 0.02), and had lower cycle day 3 follicle-stimulating hormone levels (p = 0.02). There was no difference in likelihood of achieving live birth among patients in remission and those with mild or unknown disease status (p = 0.69), though most CD patients (79.5 %) were in remission. Prior surgery was not associated with live birth in patients with UC (p = 0.31) or CD (p = 0.62). CONCLUSIONS: As in the general infertility population, younger patients and those with lower BMI were more likely to achieve live birth. History of surgery was not associated with live birth among IBD patients. This is important information for practitioners counseling IBD patients.
BACKGROUND: It is unknown whether certain factors are associated with the success of in vitro fertilization (IVF) in women with inflammatory bowel disease (IBD). AIM: This study assessed whether certain characteristics are associated with greater success of live birth following IVF. METHODS: In a cohort study of 8684 women with IBD seen at two tertiary care centers, we identified 121 women with IBD who underwent IVF. We assessed the effect of numerous factors on likelihood of achieving live birth after IVF. RESULTS: Seventy-one patients with ulcerative colitis (UC) and 49 patients with Crohn's disease (CD) were analyzed. Patients with UC who achieved a live birth were younger (p = 0.03), had a shorter duration of disease (p = 0.01), and were more likely to be in remission (p = 0.03) versus those who did not achieve live birth. Patients with CD who achieved live birth were younger (p < 0.001), had lower body mass index (BMI) (p = 0.02), and had lower cycle day 3 follicle-stimulating hormone levels (p = 0.02). There was no difference in likelihood of achieving live birth among patients in remission and those with mild or unknown disease status (p = 0.69), though most CDpatients (79.5 %) were in remission. Prior surgery was not associated with live birth in patients with UC (p = 0.31) or CD (p = 0.62). CONCLUSIONS: As in the general infertility population, younger patients and those with lower BMI were more likely to achieve live birth. History of surgery was not associated with live birth among IBD patients. This is important information for practitioners counseling IBD patients.
Entities:
Keywords:
Crohn’s disease; In vitro fertilization; Infertility; Outcomes; Ulcerative colitis
Authors: Sveta Shah Oza; Vikas Pabby; Laura E Dodge; Vasiliki A Moragianni; Michele R Hacker; Janis H Fox; Katharine Correia; Stacey A Missmer; Yetunde Ibrahim; Alan S Penzias; Robert Burakoff; Sonia Friedman; Adam S Cheifetz Journal: Clin Gastroenterol Hepatol Date: 2015-03-25 Impact factor: 11.382
Authors: M Wikland; I Jansson; M Asztély; I Palselius; G Svaninger; O Magnusson; L Hultén Journal: Int J Colorectal Dis Date: 1990-02 Impact factor: 2.571
Authors: Vikas Pabby; Sveta Shah Oza; Laura E Dodge; Michele R Hacker; Vasiliki A Moragianni; Katherine Correia; Stacey A Missmer; Janis H Fox; Yetunde Ibrahim; Alan Penzias; Robert Burakoff; Adam Cheifetz; Sonia Friedman Journal: Am J Gastroenterol Date: 2014-12-16 Impact factor: 10.864