OBJECTIVE: To investigate the independent and combined associations between female and male body mass index (BMI) on the probability of achieving a live birth after treatments with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) under adjustment for relevant covariates. DESIGN: Population-based cohort study. SETTING: Danish national registers. PATIENT(S): Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes from January 1, 2006, to September 30, 2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment. RESULT(S): In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obese women with regular ovulation had reduced odds of live birth (adjusted OR 0.88, 95% CI 0.79-0.99 and adjusted OR 0.75, 95% CI 0.63-0.90, respectively) compared with normal-weight women. IVF-treated couples with both partners having BMI ≥25 kg/m(2) had the lowest odds of live birth (adjusted OR 0.73, 95% CI 0.48-1.11) compared with couples with BMI <25 kg/m(2). BMI showed no significant effect on chance of live birth after ICSI. CONCLUSION(S): Increased female and male BMI, both independently and combined, negatively influenced live birth after IVF treatments. With ICSI, the association with BMI was less clear.
OBJECTIVE: To investigate the independent and combined associations between female and male body mass index (BMI) on the probability of achieving a live birth after treatments with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) under adjustment for relevant covariates. DESIGN: Population-based cohort study. SETTING: Danish national registers. PATIENT(S): Patients with permanent residence in Denmark receiving IVF or ICSI treatment with use of autologous oocytes from January 1, 2006, to September 30, 2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth. Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment. RESULT(S): In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obesewomen with regular ovulation had reduced odds of live birth (adjusted OR 0.88, 95% CI 0.79-0.99 and adjusted OR 0.75, 95% CI 0.63-0.90, respectively) compared with normal-weight women. IVF-treated couples with both partners having BMI ≥25 kg/m(2) had the lowest odds of live birth (adjusted OR 0.73, 95% CI 0.48-1.11) compared with couples with BMI <25 kg/m(2). BMI showed no significant effect on chance of live birth after ICSI. CONCLUSION(S): Increased female and male BMI, both independently and combined, negatively influenced live birth after IVF treatments. With ICSI, the association with BMI was less clear.
Authors: Sveta Shah Oza; Vikas Pabby; Laura E Dodge; Vasiliki A Moragianni; Michele R Hacker; Janis H Fox; Katharine Correia; Stacey A Missmer; Yetunde Ibrahim; Alan S Penzias; Robert Burakoff; Sonia Friedman; Adam S Cheifetz Journal: Clin Gastroenterol Hepatol Date: 2015-03-25 Impact factor: 11.382
Authors: Enrique F Schisterman; Sunni L Mumford; Richard W Browne; Dana Boyd Barr; Zhen Chen; Germaine M Buck Louis Journal: J Clin Endocrinol Metab Date: 2014-05-20 Impact factor: 5.958
Authors: Alex J Polotsky; Amanda A Allshouse; Peter R Casson; Christos Coutifaris; Michael P Diamond; Gregory M Christman; William D Schlaff; Ruben Alvero; J C Trussell; Stephen A Krawetz; Nanette Santoro; Esther Eisenberg; Heping Zhang; Richard S Legro Journal: J Clin Endocrinol Metab Date: 2015-04-09 Impact factor: 5.958
Authors: Karen C Schliep; Sunni L Mumford; Katherine A Ahrens; James M Hotaling; Douglas T Carrell; Megan Link; Stefanie N Hinkle; Kerri Kissell; Christina A Porucznik; Ahmad O Hammoud Journal: Fertil Steril Date: 2014-12-10 Impact factor: 7.329