Vikas Pabby1, Sveta Shah Oza2, Laura E Dodge3, Michele R Hacker3, Vasiliki A Moragianni3, Katherine Correia4, Stacey A Missmer5, Janis H Fox4, Yetunde Ibrahim3, Alan Penzias3, Robert Burakoff6, Adam Cheifetz2, Sonia Friedman6. 1. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. 2. Center for Inflammatory Bowel Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. 3. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. 4. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. 5. 1] Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA [3] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. 6. Center for Crohn's and Colitis, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Abstract
BACKGROUND: Women with ulcerative colitis (UC), who require ileal pouch anal anastomosis (IPAA), have up to a threefold increased incidence of infertility. To better counsel patients who require colectomy, we examined the success rates of in vitro fertilization (IVF) among women who have undergone IPAA. METHODS: This was a retrospective cohort study conducted at the Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Female patients with UC were identified via ICD-9 codes and cross-referenced with those presenting for IVF from 1998 through 2011. UC patients with IPAA were compared with the following two unexposed groups that underwent IVF: (1) patients with UC, who had not undergone IPAA, and (2) patients without inflammatory bowel disease (IBD). The primary outcome was the cumulative live birth rate. Secondary outcomes included number of oocytes retrieved, proportion of patients who underwent embryo transfer, pregnancy rate, and live birth rate at first cycle. RESULTS: There were 22 patients with UC and IPAA, 49 patients with UC and without IPAA, and 470 patients without IBD. The cumulative live birth rate after six cycles in the UC and IPAA groups was 64% (95% confidence interval (CI): 44-83%). This rate did not differ from the cumulative live birth rate in the UC without IPAA group (71%, 95% CI: 59-83%; P=0.63) or the group without IBD (53%, 95% CI: 48-57%; P=0.57). CONCLUSIONS: This study demonstrates that in our cohort, women who undergo IPAA achieve live births following IVF at comparable rates to women with UC without IPAA and to women without IBD.
BACKGROUND:Women with ulcerative colitis (UC), who require ileal pouch anal anastomosis (IPAA), have up to a threefold increased incidence of infertility. To better counsel patients who require colectomy, we examined the success rates of in vitro fertilization (IVF) among women who have undergone IPAA. METHODS: This was a retrospective cohort study conducted at the Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Female patients with UC were identified via ICD-9 codes and cross-referenced with those presenting for IVF from 1998 through 2011. UC patients with IPAA were compared with the following two unexposed groups that underwent IVF: (1) patients with UC, who had not undergone IPAA, and (2) patients without inflammatory bowel disease (IBD). The primary outcome was the cumulative live birth rate. Secondary outcomes included number of oocytes retrieved, proportion of patients who underwent embryo transfer, pregnancy rate, and live birth rate at first cycle. RESULTS: There were 22 patients with UC and IPAA, 49 patients with UC and without IPAA, and 470 patients without IBD. The cumulative live birth rate after six cycles in the UC and IPAA groups was 64% (95% confidence interval (CI): 44-83%). This rate did not differ from the cumulative live birth rate in the UC without IPAA group (71%, 95% CI: 59-83%; P=0.63) or the group without IBD (53%, 95% CI: 48-57%; P=0.57). CONCLUSIONS: This study demonstrates that in our cohort, women who undergo IPAA achieve live births following IVF at comparable rates to women with UC without IPAA and to women without IBD.
Authors: N Tavernier; M Fumery; L Peyrin-Biroulet; J-F Colombel; C Gower-Rousseau Journal: Aliment Pharmacol Ther Date: 2013-09-04 Impact factor: 8.171
Authors: László F J M M Bancsi; Frank J M Broekmans; Ben W J Mol; J Dik F Habbema; Egbert R te Velde Journal: Fertil Steril Date: 2003-05 Impact factor: 7.329
Authors: Christian P Selinger; Jayne Eaden; Warwick Selby; D Brian Jones; Peter Katelaris; Grace Chapman; Charles McDondald; John McLaughlin; Rupert W L Leong; Simon Lal Journal: J Crohns Colitis Date: 2012-10-02 Impact factor: 9.071
Authors: Sveta Shah Oza; Vikas Pabby; Laura E Dodge; Vasiliki A Moragianni; Michele R Hacker; Janis H Fox; Katharine Correia; Stacey A Missmer; Yetunde Ibrahim; Alan S Penzias; Robert Burakoff; Sonia Friedman; Adam S Cheifetz Journal: Clin Gastroenterol Hepatol Date: 2015-03-25 Impact factor: 11.382
Authors: Sveta Shah Oza; Vikas Pabby; Laura E Dodge; Michele R Hacker; Janis H Fox; Vasiliki A Moragianni; Katharine Correia; Stacey A Missmer; Yetunde Ibrahim; Alan S Penzias; Robert Burakoff; Sonia Friedman; Adam S Cheifetz Journal: Dig Dis Sci Date: 2016-02-18 Impact factor: 3.199
Authors: Sangmin Lee; Megan Crowe; Cynthia H Seow; Paulo G Kotze; Gilaad G Kaplan; Amy Metcalfe; Amanda Ricciuto; Eric I Benchimol; M Ellen Kuenzig Journal: J Can Assoc Gastroenterol Date: 2020-03-21