Literature DB >> 2581804

Efficient cell proliferation and predominant accumulation of epsilon-globin mRNA in human leukemic K562 cells which produce mostly Hb Gower 1.

R Gambari, F Amelotti, R Piva.   

Abstract

Long-term cultures of K562(S) cells in 50-75 microM hemin allow the selection of 'hemin-resistant' K562 cells together with cells which proliferate efficiently while fully induced to express the human embryonic globin genes, as the hemoglobin Gower 1 (zeta 2 epsilon 2) is the predominant hemoglobin produced. Our experiments demonstrate that these K562 cells accumulate mostly epsilon-globin mRNA (epsilon-globin mRNA/gamma-globin mRNA = 2.9) suggesting that the control of hemoglobin expression is at a pretranslational level.

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Year:  1985        PMID： 2581804     DOI： 10.1007/bf02007714

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  21 in total

1.  Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.

Authors:  C B Lozzio; B B Lozzio
Journal:  Blood       Date:  1975-03       Impact factor: 22.113

2.  Detection of proteins like human gamma and beta globins in Escherichia coli carrying recombinant DNA plasmids.

Authors:  L B Wilson; H E Grenett; D M Doran; F A Garver; J T Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

3.  Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein.

Authors:  M J Hayman; G M Ramsay; K Savin; G Kitchener; T Graf; H Beug
Journal:  Cell       Date:  1983-02       Impact factor: 41.582

4.  Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.

Authors:  I S Trowbridge; F Lopez
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

5.  Predominant expression of zeta and epsilon globin genes in human leukemia K-562(S6) variant cell line.

Authors:  R Gambari; G Raschellà; R Biagini; M Tripodi; M G Farace; A Romeo; A Fantoni
Journal:  Experientia       Date:  1983-04-15

6.  Hemoglobin expression in clones of K562 cell line.

Authors:  U Testa; W Vainchenker; Y Beuzard; P Rouyer-Fessard; A Guerrasio; M Titeux; P Lapotre; J Bouguet; J Breton-Gorius; J Rosa
Journal:  Eur J Biochem       Date:  1982-01

7.  Tumor promoter-mediated inhibition of cell differentiation: suppression of the expression of erythroid functions in murine erythroleukemia cells.

Authors:  E Fibach; R Gambari; P A Shaw; G Maniatis; R C Reuben; S Sassa; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

8.  The chromosomal basis of human neoplasia.

Authors:  J J Yunis
Journal:  Science       Date:  1983-07-15       Impact factor: 47.728

9.  Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

Authors:  R Sutherland; D Delia; C Schneider; R Newman; J Kemshead; M Greaves
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

10.  Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor.

Authors:  K C Robbins; H N Antoniades; S G Devare; M W Hunkapiller; S A Aaronson
Journal:  Nature       Date:  1983 Oct 13-19       Impact factor: 49.962
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  2 in total

Review 1.  Generation of erythroid cells from polyploid giant cancer cells: re-thinking about tumor blood supply.

Authors:  Zhigang Yang; Hong Yao; Fei Fei; Yuwei Li; Jie Qu; Chunyuan Li; Shiwu Zhang
Journal:  J Cancer Res Clin Oncol       Date:  2018-02-07       Impact factor: 4.553

2.  Cinchona alkaloids as natural fetal hemoglobin inducing agents in human erythroleukemia cells.

Authors:  Fizza Iftikhar; Hamad Ali; Syed Ghulam Musharraf
Journal:  RSC Adv       Date:  2019-06-04       Impact factor: 4.036
  2 in total

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