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Literature DB >> 2580945

Selective inhibition of MAO-A but not MAO-B activity increases rat pineal melatonin.

G F Oxenkrug, R McCauley, I M McIntyre, C Filipowicz.

Abstract

Clorgyline, a selective MAO-A inhibitor, increased (5 times) rat pineal melatonin and N-acetyl-serotonin (NAS) content, and decreased 5-HIAA level by 80%. Deprenyl, a selective MAO-B inhibitor, did not change melatonin or other pineal indoles content. The data obtained show that inhibition of MAO-A but not B enzyme is responsible for pineal melatonin increase caused by MAO inhibitors. It is suggested that the stimulation of melatonin synthesis caused by MAO inhibitors may contribute to their antidepressive effect.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1985 PMID： 2580945 DOI： 10.1007/bf01251917

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

18 in total

1. The development, topographical relations and innervation of the epiphysis cerebri in the albino rat.

Authors: J A KAPPERS
Journal: Z Zellforsch Mikrosk Anat Date: 1960

2. A clinical and biochemical study of a trial of iproniazid in the treatment of depression.

Authors: C M PARE; M SANDLER
Journal: J Neurol Neurosurg Psychiatry Date: 1959-08 Impact factor: 10.154

Review 3. Neuronal monoamine oxidase: specific enzyme types and their rates of formation.

Authors: N H Neff; C Goridis
Journal: Adv Biochem Psychopharmacol Date: 1972

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Authors: H Illinerová
Journal: Neuroendocrinology Date: 1974 Impact factor: 4.914

5. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase.

Authors: D C Klein; J L Weller
Journal: Science Date: 1970-09-11 Impact factor: 47.728

Review 6. Circadian rhythm mechanisms in affective illness and in antidepressant drug action.

Authors: T A Wehr; A Wirz-Justice
Journal: Pharmacopsychiatria Date: 1982-01

7. An evaluation of phospholipids as regulators of monoamine oxidase A and monoamine oxidase B activities.

Authors: C Navarro-Welch; R B McCauley
Journal: J Biol Chem Date: 1982-11-25 Impact factor: 5.157

8. Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ.

Authors: T Deguchi; J Axelrod
Journal: Proc Natl Acad Sci U S A Date: 1972-08 Impact factor: 11.205

9. Electroconvulsive shock: effect on pineal and hypothalamic indoles.

Authors: I M McIntyre; G F Oxenkrug
Journal: J Pineal Res Date: 1984 Impact factor: 13.007

10. Dopamine oxidation and its inhibition by (-)-deprenyl in man.

Authors: V Glover; J D Elsworth; M Sandler
Journal: J Neural Transm Suppl Date: 1980

12 in total

1. Possible melatonin involvement in the hypotensive effect of MAO inhibitors.

Authors: G F Oxenkrug; R B McCauley; D J Fontana; I M McIntyre; R L Commissaris
Journal: J Neural Transm Date: 1986 Impact factor: 3.575

2. The influence of acute and subchronic administration of various antidepressants on early morning melatonin plasma levels in healthy subjects: increases following fluvoxamine.

Authors: K Demisch; L Demisch; T Nickelsen; R Rieth
Journal: J Neural Transm Date: 1987 Impact factor: 3.575

6. Sympathetic denervation and chronic serotonin uptake blockade by fluoxetine do not affect pineal gland 5-hydroxyindole acetic acid: evidence that oxidative deamination of pineal serotonin is a property of the pinealocyte.

Authors: J A McNulty; V Colin
Journal: J Neural Transm Gen Sect Date: 1992

Selective inhibition of MAO-A but not MAO-B activity increases rat pineal melatonin.

1. The development, topographical relations and innervation of the epiphysis cerebri in the albino rat.

2. A clinical and biochemical study of a trial of iproniazid in the treatment of depression.

Review 3. Neuronal monoamine oxidase: specific enzyme types and their rates of formation.

4. The effect of darkness and pargyline on the activity of serotonin N-acetyltransferase in the rat epiphysis.

5. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase.

Review 6. Circadian rhythm mechanisms in affective illness and in antidepressant drug action.

7. An evaluation of phospholipids as regulators of monoamine oxidase A and monoamine oxidase B activities.

8. Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ.

9. Electroconvulsive shock: effect on pineal and hypothalamic indoles.

10. Dopamine oxidation and its inhibition by (-)-deprenyl in man.

1. Possible melatonin involvement in the hypotensive effect of MAO inhibitors.

2. The influence of acute and subchronic administration of various antidepressants on early morning melatonin plasma levels in healthy subjects: increases following fluvoxamine.

3. Marked enhancement by clorgyline of nocturnal and daytime melatonin release in rhesus monkeys.

4. In vivo degradation of noradrenaline by MAO A in locus coeruleus of the rat.

5. Chemical sympathectomy and clorgyline-induced stimulation of rat pineal melatonin synthesis.

6. Sympathetic denervation and chronic serotonin uptake blockade by fluoxetine do not affect pineal gland 5-hydroxyindole acetic acid: evidence that oxidative deamination of pineal serotonin is a property of the pinealocyte.

7. Cytochemical localization of type-A and -B monoamine oxidase in the rat pineal gland.

Review 8. N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.

Review 9. Serotonin-kynurenine hypothesis of depression: historical overview and recent developments.

10. N-acetylserotonin and aging-associated cognitive impairment and depression.